The Role of the Thioredoxin System in Redox Signaling
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 322
Interests: antioxidant molecules; anti cancer drugs; mitochondria; thiol redox regulation; thioredoxin reductase; glutathione
Special Issues, Collections and Topics in MDPI journals
Redox signaling is mediated by reactive oxygen species through the reversible oxidation of cysteines. These redox signals can modulate several signaling pathways and the whole cellular metabolism. Thus, redox regulation is of fundamental importance in different contexts from growth and developmental routes, but also in contrast to redox stressors or in the progression of several diseases. In fact, these antioxidant systems can have differential effects in the regulation of specific pathways depending on the tissue and the nutritional or pathophysiological state.
In the field of redox regulation, a central role is played by the thiol redox systems which rely on NADPH as an electron source and that include glutathione and thioredoxin systems. Regarding the thioredoxin system, the principal enzymes involved are thioredoxin reductases, thioredoxins, and peroxiredoxins. In addition, other related proteins such as glutaredoxins and thioredoxin interacting protein constitute an interplay between the thioredoxin and glutathione systems. Of these proteins, isoenzymes are often present with specific cellular localization and/or tissue specificity. Therefore, it is apparent that these systems are complex and sometimes redundant, indicating the importance of a fine redox regulation. These enzymes and their signaling network are of interest in this Special Issue.
In this Special Issue, original research articles and focused reviews dealing with the involvement of the thiol redox system in the modulation of physiological or pathological conditions are welcomed.
Dr. Maria Pia Rigobello
Dr. Valeria Scalcon
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- antioxidant systems
- redox regulation
- thioredoxin interacting protein
- thioredoxin reductases