The Role of the Thioredoxin System in Redox Signaling
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 347
Special Issue Editors
Interests: antioxidant molecules; anti cancer drugs; mitochondria; thiol redox regulation; thioredoxin reductase; glutathione
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Redox signaling is mediated by reactive oxygen species through the reversible oxidation of cysteines. These redox signals can modulate several signaling pathways and the whole cellular metabolism. Thus, redox regulation is of fundamental importance in different contexts from growth and developmental routes, but also in contrast to redox stressors or in the progression of several diseases. In fact, these antioxidant systems can have differential effects in the regulation of specific pathways depending on the tissue and the nutritional or pathophysiological state.
In the field of redox regulation, a central role is played by the thiol redox systems which rely on NADPH as an electron source and that include glutathione and thioredoxin systems. Regarding the thioredoxin system, the principal enzymes involved are thioredoxin reductases, thioredoxins, and peroxiredoxins. In addition, other related proteins such as glutaredoxins and thioredoxin interacting protein constitute an interplay between the thioredoxin and glutathione systems. Of these proteins, isoenzymes are often present with specific cellular localization and/or tissue specificity. Therefore, it is apparent that these systems are complex and sometimes redundant, indicating the importance of a fine redox regulation. These enzymes and their signaling network are of interest in this Special Issue.
In this Special Issue, original research articles and focused reviews dealing with the involvement of the thiol redox system in the modulation of physiological or pathological conditions are welcomed.
Dr. Maria Pia Rigobello
Dr. Valeria Scalcon
Guest Editors
Manuscript Submission Information
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Keywords
- antioxidant systems
- cysteines
- glutaredoxins
- peroxiredoxins
- redox regulation
- thioredoxins
- thioredoxin interacting protein
- thioredoxin reductases
