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Special Issue "The Role of Antioxidant Foods and Nutraceuticals in Ageing"

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A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 20 December 2023 | Viewed by 10053

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Special Issue Editors

Prof. Dr. Marco Giorgio

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Guest Editor

Department of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, 35131 Padova, Italy
Interests: aging; cancer; neurodegeneration; energy metabolism; bioenergetic; genomic remodeling; redox balance; mouse models; human samples; biochemical assays; omics approaches

Dr. Maria Pia Rigobello

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Guest Editor

Department of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, 35131 Padova, Italy
Interests: antioxidant molecules; anti cancer drugs; mitochondria; thiol redox regulation; thioredoxin reductase; glutathione
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Special Issue Information

Dear Colleagues,

The finding that antioxidants promote longevity or fight ageing-associated diseases is a fundamental validation of the oxidative stress theory of ageing. However, this statement is frequently turned upside down, becoming something different: A corollary of the oxidative theory of ageing is the intake of antioxidants retards ageing and increases lifespan. Because of this circular argumentation, the term antioxidant is commonly believed to be synonymous with anti-ageing, and antioxidant food is a claim for healthy food.

Several evidences indicate that antioxidants exert very different effects depending on the amounts and the experimental system. The benefits of counteracting oxidative signals to cure cancer or myocardial ischemia/reperfusion injury is controversial. Then, taking antioxidants with food or as nutraceutical supplements, systemic effects, bioavailability, derived metabolites and interactions have to be considered before drawing conclusions.

In this Special Issue, original research reports and updated literature reviews make the point on the state of the knowledge on the role of antioxidants in ageing.

Prof. Dr. Marco Giorgio
Dr. Maria Pia Rigobello
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

neurodegeneration/cognitive decline
cardiovascular ageing
cancer redox state
inflammatory diseases
stem cell exhaustion

Published Papers (4 papers)

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Research

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16 pages, 3035 KiB

Open AccessArticle

Bifidobacterium animalis MSMC83 Improves Oxidative Stress and Gut Microbiota in D-Galactose-Induced Rats

Porntipha Vitheejongjaroen

and

Antioxidants 2022, 11(11), 2146; https://doi.org/10.3390/antiox11112146 - 29 Oct 2022

Cited by 5 | Viewed by 1480

Abstract

The development of many chronic diseases is associated with an excess of free radicals leading to harmful oxidative stress. Certain probiotic strains have been shown to have antioxidant and anti-aging properties and are an important resource for development of microbial antioxidants. The present study aimed to explore the protection offered by Bifidobacterium animalis strain MSMC83 in a model of oxidative stress induced by D-galactose (D-gal). Male Sprague Dawley rats were randomly allocated to four groups: a control group injected with saline, a group injected subcutaneously with D-galactose, a probiotic group injected with D-galactose and administered B. animalis MSMC83 (10⁹ CFU/mL) via daily oral gavage, and an ascorbic acid group. The probiotics significantly increased the superoxide dismutase, catalase, and glutathione peroxidase and significantly decreased the malondialdehyde in the plasma and livers of D-galactose-treated rats. Moreover, tumor necrosis factor-alpha level in the liver was significantly decreased. Furthermore, the treatment with B. animalis MSMC83 restored the microbiota diversity after D-galactose injection. Therefore, our results supported a beneficial role of B. animalis MSMC83 in alleviating oxidative stress through the increased expression of antioxidant enzymes and reduction of pro-inflammatory cytokines in rats. Our study suggests that B. animalis MSMC83 may be part of a healthy diet to prevent oxidative stress-associated diseases. Full article

(This article belongs to the Special Issue The Role of Antioxidant Foods and Nutraceuticals in Ageing)

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15 pages, 1355 KiB

Open AccessArticle

Mangifera indica L. Leaves as a Potential Food Source of Phenolic Compounds with Biological Activity

and

Antioxidants 2022, 11(7), 1313; https://doi.org/10.3390/antiox11071313 - 30 Jun 2022

Cited by 10 | Viewed by 2978

Abstract

It is well recognized that functional foods rich in antioxidants and antiinflammation agents including polyphenols, probiotics/prebiotics, and bioactive compounds have been found to have positive effects on the aging process. In particular, fruits play an important role in regular diet, promoting good health and longevity. In this study, we investigated on biological properties of extract obtained from Mangifera indica L. leaves in preclinical in vitro models. Specifically, the profile and content of bioactive compounds, the antimicrobial potential toward food spoilage and pathogenic bacterial species, and the eventually protective effect in inflammation were examined. Our findings revealed that MLE was rich in polyphenols, showing a content exclusively in the subclass of benzophenone/xanthone metabolites, and these phytochemical compounds demonstrated the highest antioxidant capacity and greatest in vitro antibacterial activity toward different bacterial species such as Bacillus cereus, B. subtilis, Pseudomonas fluorescens, Staphylococcus aureus, and St. haemolyticus. Furthermore, our data showed an in vitro anti-inflammatory, antioxidant, and antifibrotic activity. Full article

(This article belongs to the Special Issue The Role of Antioxidant Foods and Nutraceuticals in Ageing)

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Review

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18 pages, 2341 KiB

Open AccessReview

From In Silico to a Cellular Model: Molecular Docking Approach to Evaluate Antioxidant Bioactive Peptides

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Antioxidants 2023, 12(3), 665; https://doi.org/10.3390/antiox12030665 - 08 Mar 2023

Cited by 1 | Viewed by 1739

Abstract

The increasing need to counteract the redox imbalance in chronic diseases leads to focusing research on compounds with antioxidant activity. Among natural molecules with health-promoting effects on many body functions, bioactive peptides are gaining interest. They are protein fragments of 2–20 amino acids that can be released by various mechanisms, such as gastrointestinal digestion, food processing and microbial fermentation. Recent studies report the effects of bioactive peptides in the cellular environment, and there is evidence that these compounds can exert their action by modulating specific pathways. This review focuses on the newest approaches to the structure–function correlation of the antioxidant bioactive peptides, considering their molecular mechanism, by evaluating the activation of specific signaling pathways that are linked to antioxidant systems. The correlation between the results of in silico molecular docking analysis and the effects in a cellular model was highlighted. This knowledge is fundamental in order to propose the use of bioactive peptides as ingredients in functional foods or nutraceuticals. Full article

(This article belongs to the Special Issue The Role of Antioxidant Foods and Nutraceuticals in Ageing)

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32 pages, 1900 KiB

Open AccessReview

Does Plant Breeding for Antioxidant-Rich Foods Have an Impact on Human Health?

Donatella B. M. Ficco

Elisabetta Mazzucotelli

Alessandro Tondelli

Agostino Fricano

Roberta Paris

Inmaculada García-Robles

and

Antioxidants 2022, 11(4), 794; https://doi.org/10.3390/antiox11040794 - 18 Apr 2022

Cited by 9 | Viewed by 2969

Abstract

Given the general beneficial effects of antioxidants-rich foods on human health and disease prevention, there is a continuous interest in plant secondary metabolites conferring attractive colors to fruits and grains and responsible, together with others, for nutraceutical properties. Cereals and Solanaceae are important components of the human diet, thus, they are the main targets for functional food development by exploitation of genetic resources and metabolic engineering. In this review, we focus on the impact of antioxidants-rich cereal and Solanaceae derived foods on human health by analyzing natural biodiversity and biotechnological strategies aiming at increasing the antioxidant level of grains and fruits, the impact of agronomic practices and food processing on antioxidant properties combined with a focus on the current state of pre-clinical and clinical studies. Despite the strong evidence in in vitro and animal studies supporting the beneficial effects of antioxidants-rich diets in preventing diseases, clinical studies are still not sufficient to prove the impact of antioxidant rich cereal and Solanaceae derived foods on human Full article

(This article belongs to the Special Issue The Role of Antioxidant Foods and Nutraceuticals in Ageing)

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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: From silico to cellular model: Molecular Docking Approach to evaluate antioxidant bioactive peptides
Authors: Federica Tonolo; Alessandro Grinzato; Alberto Bindoli; Maria Pia Rigobello
Affiliation: Department of Biomedical Sciences, University of Padua, Via Ugo Bassi 58/B, 35131 Padova, Italy

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Special Issue "The Role of Antioxidant Foods and Nutraceuticals in Ageing"

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