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Biosensors
Volume 10
Issue 7
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Biosensors, Volume 10, Issue 7 (July 2020) – 7 articles

Cover Story (view full-size image): Plasmonic fiber-optic biosensors combine the flexibility and compactness of optical fibers and high sensitivity of plasmonic nanomaterials to their surrounding medium, to detect biological species such as cells, proteins, and DNA. By tracking the variations in light absorption or energy loss maxima, one can detect an unknown analyte molecule bound to the surface of plasmonic nanoparticles or detect an unknown liquid analyte that is in direct contact with a plasmonic nanofilm. Due to their small size, accuracy, low-cost, and possibility of remote sensing, plasmonic fiber-optic biosensors are promising alternatives to traditional methods for biomolecule detection and can result in significant advances in clinical diagnostics, drug discovery, food process control, disease, and environmental monitoring. View this paper.
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28 pages, 3201 KiB  
Review
Skin-Integrated Wearable Systems and Implantable Biosensors: A Comprehensive Review
by Daniela Rodrigues, Ana I. Barbosa, Rita Rebelo, Il Keun Kwon, Rui L. Reis and Vitor M. Correlo
Biosensors 2020, 10(7), 79; https://doi.org/10.3390/bios10070079 - 21 Jul 2020
Cited by 95 | Viewed by 13868
Abstract
Biosensors devices have attracted the attention of many researchers across the world. They have the capability to solve a large number of analytical problems and challenges. They are future ubiquitous devices for disease diagnosis, monitoring, treatment and health management. This review presents an [...] Read more.
Biosensors devices have attracted the attention of many researchers across the world. They have the capability to solve a large number of analytical problems and challenges. They are future ubiquitous devices for disease diagnosis, monitoring, treatment and health management. This review presents an overview of the biosensors field, highlighting the current research and development of bio-integrated and implanted biosensors. These devices are micro- and nano-fabricated, according to numerous techniques that are adapted in order to offer a suitable mechanical match of the biosensor to the surrounding tissue, and therefore decrease the body’s biological response. For this, most of the skin-integrated and implanted biosensors use a polymer layer as a versatile and flexible structural support, combined with a functional/active material, to generate, transmit and process the obtained signal. A few challenging issues of implantable biosensor devices, as well as strategies to overcome them, are also discussed in this review, including biological response, power supply, and data communication. Full article
(This article belongs to the Section Nano- and Micro-Technologies in Biosensors)
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9 pages, 2100 KiB  
Article
Electrochemical DNA Sensor for Sensitive BRCA1 Detection Based on DNA Tetrahedral-Structured Probe and Poly-Adenine Mediated Gold Nanoparticles
by Dezhi Feng, Jing Su, Guifang He, Yi Xu, Chenguang Wang, Mengmeng Zheng, Qiuling Qian and Xianqiang Mi
Biosensors 2020, 10(7), 78; https://doi.org/10.3390/bios10070078 - 20 Jul 2020
Cited by 19 | Viewed by 4479
Abstract
BRCA1 is the biomarker for the early diagnosis of breast cancer. Detection of BRCA1 has great significance for the genetic analysis, early diagnosis and clinical treatment of breast cancer. In this work, we developed a simple electrochemical DNA sensor based on a DNA [...] Read more.
BRCA1 is the biomarker for the early diagnosis of breast cancer. Detection of BRCA1 has great significance for the genetic analysis, early diagnosis and clinical treatment of breast cancer. In this work, we developed a simple electrochemical DNA sensor based on a DNA tetrahedral-structured probe (TSP) and poly-adenine (polyA) mediated gold nanoparticles (AuNPs) for the sensitive detection of BRCA1. A thiol-modified TSP was used as the scaffold on the surface of the screen-printed AuNPs electrode. The capture DNA (TSP) and reporter DNA were hybridized to the target DNA (BRCA1), respectively, to form the typical sandwich system. The nanocomposites of reporter DNA (polyA at the 5′ end) combined with AuNPs were employed for signal amplification which can capture multiple enzymes by the specificity between biotin and streptavidin. Measurements were completed in the electrochemical workstation by cyclic voltammetry and amperometry and we obtained the low limit of detection of 0.1 fM with the linear range from 1 fM to 1 nM. High sensitivity and good specificity of the proposed electrochemical DNA sensor showed potential applications in clinical early diagnosis for breast cancer. Full article
(This article belongs to the Special Issue Electrochemical Biosensors)
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22 pages, 5591 KiB  
Review
Overview of Recent Advances in the Design of Plasmonic Fiber-Optic Biosensors
by Yashar Esfahani Monfared
Biosensors 2020, 10(7), 77; https://doi.org/10.3390/bios10070077 - 09 Jul 2020
Cited by 85 | Viewed by 7287
Abstract
Plasmonic fiber-optic biosensors combine the flexibility and compactness of optical fibers and high sensitivity of nanomaterials to their surrounding medium, to detect biological species such as cells, proteins, and DNA. Due to their small size, accuracy, low cost, and possibility of remote and [...] Read more.
Plasmonic fiber-optic biosensors combine the flexibility and compactness of optical fibers and high sensitivity of nanomaterials to their surrounding medium, to detect biological species such as cells, proteins, and DNA. Due to their small size, accuracy, low cost, and possibility of remote and distributed sensing, plasmonic fiber-optic biosensors are promising alternatives to traditional methods for biomolecule detection, and can result in significant advances in clinical diagnostics, drug discovery, food process control, disease, and environmental monitoring. In this review article, we overview the key plasmonic fiber-optic biosensing design concepts, including geometries based on conventional optical fibers like unclad, side-polished, tapered, and U-shaped fiber designs, and geometries based on specialty optical fibers, such as photonic crystal fibers and tilted fiber Bragg gratings. The review will be of benefit to both engineers in the field of optical fiber technology and scientists in the fields of biosensing. Full article
(This article belongs to the Special Issue Last Advances in Optical Biosensors)
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29 pages, 6745 KiB  
Review
Screen-Printed Electrodes: Promising Paper and Wearable Transducers for (Bio)Sensing
by Paloma Yáñez-Sedeño, Susana Campuzano and José Manuel Pingarrón
Biosensors 2020, 10(7), 76; https://doi.org/10.3390/bios10070076 - 09 Jul 2020
Cited by 66 | Viewed by 9506
Abstract
Screen-printing technology has revolutionized many fields, including that of electrochemical biosensing. Due to their current relevance, this review, unlike other papers, discusses the relevant aspects of electrochemical biosensors manufactured using this technology in connection to both paper substrates and wearable formats. The main [...] Read more.
Screen-printing technology has revolutionized many fields, including that of electrochemical biosensing. Due to their current relevance, this review, unlike other papers, discusses the relevant aspects of electrochemical biosensors manufactured using this technology in connection to both paper substrates and wearable formats. The main trends, advances, and opportunities provided by these types of devices, with particular attention to the environmental and biomedical fields, are addressed along with illustrative fundamentals and applications of selected representative approaches from the recent literature. The main challenges and future directions to tackle in this research area are also pointed out. Full article
(This article belongs to the Special Issue Dedication to Professor Agustín Costa-García: Screen-Printed Electrodes-Based (Bio)sensors: Development and New Challenges of the 21st Century)
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12 pages, 3633 KiB  
Article
A Self-Powered Biosensor for Monitoring Maximal Lactate Steady State in Sport Training
by Yupeng Mao, Wen Yue, Tianming Zhao, MaiLun Shen, Bing Liu and Song Chen
Biosensors 2020, 10(7), 75; https://doi.org/10.3390/bios10070075 - 08 Jul 2020
Cited by 33 | Viewed by 4883
Abstract
A self-powered biosensor for monitoring the maximal lactate steady state (MLSS) during exercise has been developed for intelligently assisting training system. It has been presented to create poly (vinylidene fluoride) (PVDF)/Tetrapod-shaped ZnO (T-ZnO)/enzyme-modified nanocomposite film through an efficient and cost-effective fabrication process. This [...] Read more.
A self-powered biosensor for monitoring the maximal lactate steady state (MLSS) during exercise has been developed for intelligently assisting training system. It has been presented to create poly (vinylidene fluoride) (PVDF)/Tetrapod-shaped ZnO (T-ZnO)/enzyme-modified nanocomposite film through an efficient and cost-effective fabrication process. This sensor can be readily attached to the skin surface of the tester. Due to the piezoelectric surface coupling effect, this biosensor can monitor/sense and analyze physical information in real-time under the non-invasive condition and work independently without any battery. By actively outputting piezoelectric signals, it can quickly and sensitively detect body movements (changes of joint angle, frequency relative humidity during exercise) and physiological information (changes of lactate concentration in sweat). A practical application has been demonstrated by an excellent professional speed skater (male). The purpose of this study is to increase the efficiency of MLSS evaluation, promote the development of piezoelectric surface coupling effect and motion monitoring application, develop an intelligently assisting training system, which has opened up a new direction for human motion monitoring. Full article
(This article belongs to the Section Biosensors and Healthcare)
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22 pages, 5877 KiB  
Article
Factors Influencing the Long-Term Stability of Electronic Tongue and Application of Improved Drift Correction Methods
by Zoltan Kovacs, Dániel Szöllősi, John-Lewis Zinia Zaukuu, Zsanett Bodor, Flóra Vitális, Balkis Aouadi, Viktória Zsom-Muha and Zoltan Gillay
Biosensors 2020, 10(7), 74; https://doi.org/10.3390/bios10070074 - 07 Jul 2020
Cited by 28 | Viewed by 4026
Abstract
Temperature, memory effect, and cross-contamination are suspected to contribute to drift in electronic tongue (e-tongue) sensors, therefore drift corrections are required. This paper aimed to assess the disturbing effects on the sensor signals during measurement with an Alpha Astree e-tongue and to develop [...] Read more.
Temperature, memory effect, and cross-contamination are suspected to contribute to drift in electronic tongue (e-tongue) sensors, therefore drift corrections are required. This paper aimed to assess the disturbing effects on the sensor signals during measurement with an Alpha Astree e-tongue and to develop drift correction techniques. Apple juice samples were measured at different temperatures. pH change of apple juice samples was measured to assess cross-contamination. Different sequential orders of model solutions and apple juice samples were applied to evaluate the memory effect. Model solutions corresponding to basic tastes and commercial apple juice samples were measured for six consecutive weeks to model drift of the sensor signals. Result showed that temperature, cross-contamination, and memory effect influenced the sensor signals. Three drift correction methods: additive drift correction based on all samples, additive drift correction based on reference samples, and multi sensor linear correction, were developed and compared to the component correction in literature through linear discriminant analysis (LDA). LDA analysis showed all the four methods were effective in reducing sensor drift in long-term measurements but the additive correction relative to the whole sample set gave the best results. The results could be explored for long-term measurements with the e-tongue. Full article
(This article belongs to the Section Intelligent Biosensors and Bio-Signal Processing)
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6 pages, 181 KiB  
Editorial
Noninvasive Early Disease Diagnosis by Electronic-Nose and Related VOC-Detection Devices
by Alphus Dan Wilson
Biosensors 2020, 10(7), 73; https://doi.org/10.3390/bios10070073 - 06 Jul 2020
Cited by 38 | Viewed by 5037
Abstract
This editorial provides an overview and summary of recent research articles published in Biosensors journal, volumes 9 (2019) and 10 (2020), within the Special Issue “Noninvasive Early Disease Diagnosis”, which focused on recent sensors, biosensors, and clinical instruments developed for the [...] Read more.
This editorial provides an overview and summary of recent research articles published in Biosensors journal, volumes 9 (2019) and 10 (2020), within the Special Issue “Noninvasive Early Disease Diagnosis”, which focused on recent sensors, biosensors, and clinical instruments developed for the noninvasive early detection and diagnosis of human, animal, and plant diseases or invasive pests. The six research articles included in this Special Issue provide examples of some of the latest electronic-nose (e-nose) and related volatile organic compound (VOC)-detection technologies, which are being tested and developed to improve the effectiveness and efficiency of innovative diagnostic methodologies for the early detection of particular diseases and pest infestations in living hosts, prior to symptom development. Full article
(This article belongs to the Special Issue Noninvasive Early Disease Diagnosis)
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