A Review on Autophagy in Orofacial Neuropathic Pain

Round 1

Reviewer 1 Report

This is a comprehensive and in-depth review paper on orofacial neuropathic pain and autophage. It is well-written and provides an insight on the pivotal role of autophage in the development of orofacial neuropathic pain. Therefore, I recommend it to be published in Cells.

Author Response

Response to Reviewers: Thank you for the opportunity to address the reviewers comments and revise the manuscript accordingly. All revisions in the manuscript are marked using track changes. We modified each section of the paper in order to reduce the similarity.

 

Reviewer 1: This is a comprehensive and in-depth review paper on orofacial neuropathic pain and autophage. It is well-written and provides an insight on the pivotal role of autophage in the development of orofacial neuropathic pain. Therefore, I recommend it to be published in Cells.

 

Comments: We are grateful to you. We really appreciate the time and effort that you have dedicated to our manuscript. Thank you!

 

Sincerely,

Mayank Shrivastava DDS, MS, Liang Ye DDS PhD

Reviewer 2 Report

The manuscript entitled "A Review on Autophagy in Orofacial Neuropathic Pain" submitted by Mayank Shrivastava and Liang Ye. The authors state the issue of autophagy is a very valuable subject in light of recent reports which is based on clinical presentation, assessment, pathophysiology and treatment of orofacial neuropathic pain.

1. The different types of neuropathic pain given that difference in characteristics, pathophysiology, neurobiology, and assessment clinically.

2. The reactive oxygen species, mitotoxicity, inflammation, and endoplasmic reticulum stress, results in the dysregulation of autophagy, a crucial intracellular degradation process, bringing up neuropathic pain.

In this review article, the authors provide the therapeutic potential of autophagy and clinical management of orofacial neuropathic pain. Although the role of autophagy has not been explored in orofacial neuropathic pain models; given this more studies are needed in order to understand and assess the role of autophagy in modulation of orofacial neuropathic pain in experimental models.

 

Major concerns

1.     The authors should unify the key terms in title, keywords, and text in this manuscript: for example, orofacial neuropathic pain or neuropathic orofacial pain?

2.     In line 22, either acute and chronic pain? In line 53, acute nerve injury chronic neuropathic pain? In line 90, and and? In line 477, 3.2. Therapeutic potential of autophagy in management of Orofacial Neuropathic?.. I advise the help of a native English or professional English writer to help review the main manuscript.

3.     In line 250, These immune cells are released by the damaged neurons? I have no idea about this sentence means?

Author Response

Please see the attachment.  We uploaded the response to reviewer's comment.

Thanks a lot!

Author Response File: Author Response.pdf