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Marine Biotoxins and Bioactive Marine Natural Products
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Division of Biomedical Food Research, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki 210-9501, Kanagawa, Japan
Department Analytical and Food Chemistry, Biomedical Research Center (CINBIO) Universidade de Vigo, 36310 Vigo, Spain
Department of Biological Chemistry, School of Science, Osaka Metropolitan University, Osaka, Japan
Department of Food Science and Technology, National Fisheries University, Yamaguchi, Japan
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Marine Biotoxins and Bioactive Marine Natural Products

Abstract submission deadline
30 June 2024
Manuscript submission deadline
31 August 2024
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1451

Topic Information

Dear Colleagues,

Marine biotoxins are bioactive marine natural products produced by microorganisms such as dinoflagellates, diatoms, cyanobacteria, and bacteria. These toxins are often transmitted through the food chain and accumulate in marine organisms consumed as seafood. When humans consume poisonous seafood, this can severely affect their health and in some cases lead to death. Elucidating the chemical characterization of marine biotoxins is one of the most essential aspects of assessing and managing the human health risks posed by seafood. Furthermore, understanding the ecology, distribution, and physiology of organisms that produce, multiply, and accumulate toxins is an important research area in order to understand the dynamics of marine toxins in the marine environment.

The Topic “Marine Biotoxins and Bioactive Marine Natural Products” aims to bring together the latest knowledge in the field to elucidate the dynamics and pathogenesis of marine biological toxins.

Dr. Naomasa Oshiro
Prof. Dr. Ana Gago-Martínez
Prof. Dr. Takeshi Tsumuraya
Prof. Dr. Tsuyoshi Ikehara
Topic Editors

Keywords

  • marine biotoxin
  • marine natural products
  • seafood safety
  • food poisoning
  • toxinology
  • ciguatera poisoning
  • shellfish poisoning
  • tetrodotoxin

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Applied Biosciences
applbiosci 		- - 2022 37.7 Days CHF 1000 Submit
Journal of Marine Science and Engineering
jmse 		2.9 3.7 2013 15.4 Days CHF 2600 Submit
Marine Drugs
marinedrugs 		5.4 9.6 2003 14 Days CHF 2900 Submit
Toxins
toxins 		4.2 7.5 2009 18.4 Days CHF 2700 Submit
Molecules
molecules 		4.6 6.7 1996 14.6 Days CHF 2700 Submit

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Published Papers (1 paper)

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Article
Sensitive Detection of Ciguatoxins Using a Neuroblastoma Cell-Based Assay with Voltage-Gated Potassium Channel Inhibitors
by Toshiaki Yokozeki, Madoka Kawabata, Kazuhiro Fujita, Masahiro Hirama and Takeshi Tsumuraya
Toxins 2024, 16(3), 118; https://doi.org/10.3390/toxins16030118 - 29 Feb 2024
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Abstract
Ciguatoxins (CTXs) are neurotoxins responsible for ciguatera poisoning (CP), which affects more than 50,000 people worldwide annually. The development of analytical methods to prevent CP is a pressing global issue, and the N2a assay is one of the most promising methods for detecting [...] Read more.
Ciguatoxins (CTXs) are neurotoxins responsible for ciguatera poisoning (CP), which affects more than 50,000 people worldwide annually. The development of analytical methods to prevent CP is a pressing global issue, and the N2a assay is one of the most promising methods for detecting CTXs. CTXs are highly toxic, and an action level of 0.01 μg CTX1B equivalent (eq)/kg in fish has been proposed. It is desirable to further increase the detection sensitivity of CTXs in the N2a assay to detect such low concentrations reliably. The opening of voltage-gated sodium channels (NaV channels) and blocking of voltage-gated potassium channels (KV channels) are thought to be involved in the toxicity of CTXs. Therefore, in this study, we developed an assay that could detect CTXs with higher sensitivity than conventional N2a assays, using KV channel inhibitors as sensitizing reagents for N2a cells. The addition of the KV channel inhibitors 4-aminopyridine and tetraethylammonium chloride to N2a cells, in addition to the traditional sensitizing reagents ouabain and veratridine, increased the sensitivity of N2a cells to CTXs by up to approximately 4-fold. This is also the first study to demonstrate the influence of KV channels on the toxicity of CTXs in a cell-based assay. Full article
(This article belongs to the Topic Marine Biotoxins and Bioactive Marine Natural Products)
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