Kinases in Cancer and Other Diseases, 2nd Edition

Topic Information

Dear Colleagues,

Protein kinases comprise a large family of enzymes that catalyze protein phosphorylation. The human genome contains 518 protein kinase genes. Phosphorylation is one of the major mechanisms for regulating various cellular processes, such as proliferation, the apoptosis cell cycle, growth, apoptosis, differentiation, etc. The deregulation of kinase activity can result in significant changes in these processes. Furthermore, deregulated kinases are often oncogenic and essential for the survival and spreading of cancer cells. There are different ways in which kinases are involved in cancers, including misregulated expression and/or amplification, mutation, chromosomal translocation, abnormal phosphorylation, and epigenetic regulation. In order to further investigage these functions, there are various scientific projects assessing the importance of kinases in cancers as well as several other diseases, such as polycystic kidney disease, glomerulonephritis, neurodegeneration, retinal degeneration, lung inflammation, etc. In clinical science the major two kinase investigation routes are (1) using kinases as biomarkers in cancer prognostics and diagnostics and (2) treating cancers with kinase inhibitors and/or monoclonal antibodies. This Topic will highlight current and innovative research achievements in these areas.

Dr. Jonas Cicenas
Dr. Anna M. Czarnecka
Topic Editors

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Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Biology biology	4.2	4.0	2012	18.8 Days	CHF 2700	Submit
Biomolecules biomolecules	5.5	8.3	2011	19.2 Days	CHF 2700	Submit
Cancers cancers	5.2	7.4	2009	18.2 Days	CHF 2900	Submit
Cells cells	6.0	9.0	2012	18.8 Days	CHF 2700	Submit
International Journal of Molecular Sciences ijms	5.6	7.8	2000	16.8 Days	CHF 2900	Submit
Pharmaceuticals pharmaceuticals	4.6	4.7	2004	15.7 Days	CHF 2900	Submit

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