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2. MAP Kinase Resource, Bioinformatics, Melchiorstrasse 9, CH-3027 Bern, Switzerland
Kinases in Cancer and Other Diseases
Protein kinases comprise a large family of enzymes that catalyze protein phosphorylation. The human genome contains 518 protein kinase genes. Phosphorylation is one of the major mechanisms for regulating various cellular processes, such as proliferation, the apoptosis cell cycle, growth, apoptosis, differentiation, etc. The deregulation of kinase activity can result in significant changes in these processes. Furthermore, deregulated kinases are often oncogenic and essential for the survival and spreading of cancer cells . There are different ways in which kinases are involved in cancers, including misregulated expression and/or amplification, mutation, chromosomal translocation, abnormal phosphorylation, and epigenetic regulation. In order to further investigage these functions, there are various scientific projects assessing the importance of kinases in cancers as well as several other diseases, such as polycystic kidney disease, glomerulonephritis, neurodegeneration, retinal degeneration, lung inflammation, etc. In clinical science the major two kinase investigation routes are 1.) using kinases as biomarkers in cancer prognostics and diagnostics and 2.) treating cancers with kinase inhibitors and/or monoclonal antibodies. This Topic will highlight current and innovatine research achievements in these areas.
Dr. Jonas Cicenas
Dr. May C. Morris
- protein kinases
- protein phosphorylation
|Journal Name||Impact Factor||CiteScore||Launched Year||First Decision (median)||APC|
|6.064||5.7||2011||16.6 Days||2300 CHF|
|6.575||5.8||2009||17.4 Days||2600 CHF|
|3.109||3.5||1994||19.6 Days||1800 CHF|
International Journal of Molecular Sciencesijms
|6.208||6.9||2000||15.9 Days||2500 CHF|
|-||-||2021||15.0 days *||1000 CHF|
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