Counter-Current Chromatography in Natural Products Isolation
Counter-current chromatography (CCC) is a unique liquid–liquid partition chromatography. Without use of solids as support matrices, CCC eliminates many complications resulting from solid-supporting materials, such as irreversible absorption, constituent losses and deactivation, tailing of solute peaks and contamination. In addition, by comparison with other solid-support chromatography including silica column chromatography and reversed-phase liquid chromatography, CCC has more advantages such as a higher retention of a stationary phase, a better selection and more solvent-saving. Therefore, CCC has been widely employed for separation and preparation of natural and synthetic compounds from complex mixtures in many fields. In discussing this topic, we will focus on the separation and purification of bioactive natural products by CCC or CCC-involved separation techniques. Novel CCC instruments and separation methods developments are encouraged, and general reviews and experimental reports are welcome.
Dr. Shihua Wu
Dr. Zhi Yang
Dr. Xinyi Huang
- counter-current chromatography
- natural products
- indigenous drugs
- traditional medicines
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