Topic Editors

1. School of Ecology and Environment, Tibet University, Lhasa 850000, China
2. The Research Center of Siyuan Natural Pharmacy and Bio-Toxicology, College of Life Sciences, Zhejiang University, Hangzhou 310058, China
School of Chemistry and Pharmacy, Northwest Agriculture and Forestry University, Xianyang, China
Dr. Xinyi Huang
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China

Counter-Current Chromatography in Natural Products Isolation

Abstract submission deadline
31 January 2025
Manuscript submission deadline
31 March 2025
Viewed by
1988

Topic Information

Dear Colleagues,

Counter-current chromatography (CCC) is a unique liquid–liquid partition chromatography. Without use of solids as support matrices, CCC eliminates many complications resulting from solid-supporting materials, such as irreversible absorption, constituent losses and deactivation, tailing of solute peaks and contamination. In addition, by comparison with other solid-support chromatography including silica column chromatography and reversed-phase liquid chromatography, CCC has more advantages such as a higher retention of a stationary phase, a better selection and more solvent-saving. Therefore, CCC has been widely employed for separation and preparation of natural and synthetic compounds from complex mixtures in many fields. In discussing this topic, we will focus on the separation and purification of bioactive natural products by CCC or CCC-involved separation techniques. Novel CCC instruments and separation methods developments are encouraged, and general reviews and experimental reports are welcome.

Dr. Shihua Wu
Dr. Zhi Yang
Dr. Xinyi Huang
Topic Editors

Keywords

  • counter-current chromatography
  • natural products
  • indigenous drugs
  • traditional medicines
  • separation
  • purification

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Analytica
analytica
- - 2020 15.6 Days CHF 1000 Submit
Metabolites
metabolites
4.1 5.3 2011 13.2 Days CHF 2700 Submit
Molecules
molecules
4.6 6.7 1996 14.6 Days CHF 2700 Submit
Separations
separations
2.6 2.5 2014 13.6 Days CHF 2600 Submit
Toxins
toxins
4.2 7.5 2009 18.4 Days CHF 2700 Submit

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Published Papers (1 paper)

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13 pages, 1715 KiB  
Article
Bioactivity-Guided High Performance Counter-Current Chromatography and Following Semi-Preparative Liquid Chromatography Method for Rapid Isolation of Anti-Inflammatory Lignins from Dai Medicinal Plant, Zanthoxylum acanthopodium var. timbor
by Qing-Fei Fan, Lan Zhou, Pian-Chou Gongpan, Chuan-Li Lu, Hua Chang and Xun Xiang
Molecules 2023, 28(6), 2592; https://doi.org/10.3390/molecules28062592 - 13 Mar 2023
Cited by 2 | Viewed by 1074
Abstract
The development of Dai medicine is relatively slow, and Zanthoxylum has great economic and medicinal value. It is still difficult to obtain medicinal components from the low-polarity parts of Zanthoxylum belonging to Dai medicine. In this study, we introduced one simple and quick [...] Read more.
The development of Dai medicine is relatively slow, and Zanthoxylum has great economic and medicinal value. It is still difficult to obtain medicinal components from the low-polarity parts of Zanthoxylum belonging to Dai medicine. In this study, we introduced one simple and quick strategy of separating target compounds from the barks of Z. acanthopodium var. timbor by high-performance countercurrent chromatography (HPCCC) with an off-line anti-inflammatory activity screening mode. The development of this strategy was based on the TLC-based generally useful estimation of solvent systems (GUESS) method and HPCCC in combination. This paper presented a rapid method for obtaining target anti-inflammatory compounds. Three lignins were enriched by HPCCC with an off-line inhibition mode of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophage cells, using petroleum ether–ethyl acetate–methanol–water (3:2:3:2) as the solvent system. The results showed that this method was simple and practical and could be applied to trace the anti-inflammatory components of the low-polarity part in Dai medicine. Full article
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