Viruses and Non-Coding RNAs

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "General Virology".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 3328

Special Issue Editors


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Guest Editor
Experimental Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Interests: HPV; HPV-induced transformation; cancer biology; miRNAs; biomarkers for early cancer detection and risk stratification

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Guest Editor
Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien 97004, Taiwan
Interests: influenza A virus; hepatitis C virus; coronaviruses; translational control; viral replication; virus-host interactions
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Guest Editor
College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
Interests: dissecting the epigenetic regulation of periodontal disease and host–pathogen interaction

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Guest Editor
Tumor Virus RNA Biology Section, RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
Interests: HPV; KSHV; tumor viruses; RNA splicing; RNA-protein interactions; noncoding RNA; RNA processing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue, entitled "Viruses and Non-Coding RNAs", aims to present recent research on the non-coding RNAs (both host and virus-encoded) and their regulations on host gene expression in various virus infections. Non-coding RNAs are increasingly acknowledged in shaping host–virus interaction and modulating antiviral responses and immune evasion. The delineating mechanism involved in this interaction will unravel novel biomarkers and targets for diagnosis and treatment of viral diseases. Novel bioinformatics tools to assess host–virus interaction via non-coding RNAs can advance our understanding of the complex molecular relationship.

The focal points of this Special Issue include, but are not limited to, the following:

  1. Mechanisms of viral non-coding RNA production in virus life cycles and virus infection-induced production of host non-coding RNAs;
  2. Mechanisms of non-coding RNAs in regulation of viral recognition and antiviral immunity;
  3. The role of host and viral non-coding RNA in viral replication, persistence, and pathogenesis;
  4. Immunological studies describing the unique antiviral functions of non-coding RNA;
  5. Bioinformatics tools to study non-coding RNA interaction with host and viral transcriptome;
  6. Pre-clinical and clinical studies describing the contribution of non-coding RNAs as biomarkers in viral nfection and virus-induced disease;
  7. Therapeutic targeting of non-coding RNAs in viral infection.

Reviews, original research, and communications are welcome.

Prof. Dr. Renske D.M. Steenbergen
Dr. Shih-Yen Lo
Dr. Afsar Naqvi
Dr. Zhi-Ming Zheng
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • viral infections
  • microRNAs
  • long noncoding RNAs
  • antiviral immunity
  • post-transcriptional regulation
  • virus diagnostics and therapeutics

Published Papers (2 papers)

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Review

25 pages, 2185 KiB  
Review
Regulatory Non-Coding RNAs during Porcine Viral Infections: Potential Targets for Antiviral Therapy
by Feng Li, Hao Yu, Aosi Qi, Tianyi Zhang, Yuran Huo, Qiuse Tu, Chunyun Qi, Heyong Wu, Xi Wang, Jian Zhou, Lanxin Hu, Hongsheng Ouyang, Daxin Pang and Zicong Xie
Viruses 2024, 16(1), 118; https://doi.org/10.3390/v16010118 - 13 Jan 2024
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Abstract
Pigs play important roles in agriculture and bio-medicine; however, porcine viral infections have caused huge losses to the pig industry and severely affected the animal welfare and social public safety. During viral infections, many non-coding RNAs are induced or repressed by viruses and [...] Read more.
Pigs play important roles in agriculture and bio-medicine; however, porcine viral infections have caused huge losses to the pig industry and severely affected the animal welfare and social public safety. During viral infections, many non-coding RNAs are induced or repressed by viruses and regulate viral infection. Many viruses have, therefore, developed a number of mechanisms that use ncRNAs to evade the host immune system. Understanding how ncRNAs regulate host immunity during porcine viral infections is critical for the development of antiviral therapies. In this review, we provide a summary of the classification, production and function of ncRNAs involved in regulating porcine viral infections. Additionally, we outline pathways and modes of action by which ncRNAs regulate viral infections and highlight the therapeutic potential of artificial microRNA. Our hope is that this information will aid in the development of antiviral therapies based on ncRNAs for the pig industry. Full article
(This article belongs to the Special Issue Viruses and Non-Coding RNAs)
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17 pages, 1732 KiB  
Review
Subgenomic Flaviviral RNAs of Dengue Viruses
by Yi Liu, Wuxiang Guan and Haibin Liu
Viruses 2023, 15(12), 2306; https://doi.org/10.3390/v15122306 - 24 Nov 2023
Viewed by 1409
Abstract
Subgenomic flaviviral RNAs (sfRNAs) are produced during flavivirus infections in both arthropod and vertebrate cells. They are undegraded products originating from the viral 3′ untranslated region (3′ UTR), a result of the action of the host 5′-3′ exoribonuclease, Xrn1, when it encounters specific [...] Read more.
Subgenomic flaviviral RNAs (sfRNAs) are produced during flavivirus infections in both arthropod and vertebrate cells. They are undegraded products originating from the viral 3′ untranslated region (3′ UTR), a result of the action of the host 5′-3′ exoribonuclease, Xrn1, when it encounters specific RNA structures known as Xrn1-resistant RNAs (xrRNAs) within the viral 3′ UTR. Dengue viruses generate three to four distinct species of sfRNAs through the presence of two xrRNAs and two dumbbell structures (DBs). The tertiary structures of xrRNAs have been characterized to form a ringlike structure around the 5′ end of the viral RNA, effectively inhibiting the activity of Xrn1. The most important role of DENV sfRNAs is to inhibit host antiviral responses by interacting with viral and host proteins, thereby influencing viral pathogenicity, replicative fitness, epidemiological fitness, and transmission. In this review, we aimed to summarize the biogenesis, structures, and functions of DENV sfRNAs, exploring their implications for viral interference. Full article
(This article belongs to the Special Issue Viruses and Non-Coding RNAs)
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