Special Issue "From RSV to hMPV: Role of Innate Immunity in Pathogenesis"
Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 47905
Interests: reactive oxygen species; pediatric infectious diseases; respiratory viral pathogens; lung inflammation; cellular signaling
Interests: molecular mechanisms underlying the pathogenesis and host immune responses associated with RSV and hMPV infections; respiratory tract infections; antiviral pathways; viral evasion mechanisms; sncRNAs
Several millions of lower respiratory tract infections (LRTIs) in infants and children are caused every year worldwide by respiratory syncytial virus (RSV). The pathogenesis of RSV LRTIs and the cellular/molecular mechanisms that determine its clinical severity are not completely understood. Numerous studies over the past fifty years have revealed that host determinants—including T cell-mediated immune responses, neurogenic inflammation, epithelial-derived inflammatory cytokines/chemokines, pro-oxidative mediators, neutrophils, dendritic cells, and monocytes/macrophages—are involved in the obstruction and damage of the small airways and associated clinical manifestations that are characteristic of RSV LRTIs. The rapidly advancing field of omics sciences has contributed to the discovery of new gene/protein/cell innate pathways, such as the NF-kB-, NRF2-, and interferon-regulated networks, which control immunity and inflammation of the lung in human natural acquired RSV infections and animal experimental models. The aim of this Special Issue of Viruses is to contribute to the current knowledge on cellular and molecular components of the innate immune system that are implicated in the pathogenesis of RSV airway disease, acute and chronic airway inflammation, the regulation of adaptive immune responses, as well as antiviral activity.
Prof. Antonella Casola
Prof. Roberto P. Garofalo
Prof. Xiaoyong Bao
Manuscript Submission Information
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- RSV pathogenesis
- Innate immunity
- Mucosal immune response
- Determinants of disease severity