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Viruses
Special Issues
Papillomavirus-Induced Oncogenesis: Current Insights and Future Directions
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Papillomavirus-Induced Oncogenesis: Current Insights and Future Directions

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 2448

Special Issue Editors

Dr. Hossein H. Ashrafi

E-Mail Website
Guest Editor
School of Life Science, Pharmacy and Chemistry, Kingston University London, London, UK
Interests: Human Papillomavirus (HPV); Varizella-Zoster-Virus (VZV)
Prof. Dr. Mustafa Ozdogan

E-Mail Website
Guest Editor
Professor of Oncology, Head of Memorial Cancer Center, Antalya, Turkey
Interests: cancer biology; clinical oncology; cancer therapeutics; head and neck cancers; Human Papilloma Virus (HPV) related cancers

Special Issue Information

Dear Colleagues,

Papillomaviruses (PVs) encompass a diverse family of viruses, with over 100 identified types, 13 of which are recognized as carcinogenic. These viruses have been implicated in a range of oncogenic processes across various anatomical sites, presenting a complex area of study within the field of virology and oncology. Understanding the underlying mechanisms and clinical implications of papillomavirus-induced oncogenesis is thus of paramount importance.

This Special Issue aims to provide a comprehensive platform for the exploration of current insights and future directions in papillomavirus-induced oncogenesis. We invite contributions covering a wide array of topics, including but not limited to:

  • Elucidating the molecular and cellular mechanisms underpinning papillomavirus-induced oncogenesis, spanning a diverse range of anatomical sites;
  • Advances in the development and application of diagnostic tools and techniques for detecting papillomavirus infections and associated malignancies;
  • Epidemiological studies and analyses of trends in papillomavirus-associated cancers, providing critical insights into the global burden of these malignancies;
  • Innovative therapeutic approaches, including immunotherapies, targeted interventions, and the exploration of potential biomarkers for personalized treatment strategies;
  • Evaluation of vaccination against papillomaviruses, assessing their impact on prevention, risk reduction, and potential applications beyond established indications.

We welcome contributions from researchers, clinicians, and experts in the field, with the aim of fostering a comprehensive understanding of the complex interplay between papillomaviruses and oncogenesis across diverse anatomical contexts. Muharrem Okan Cakir will provide valuable support to the co-editor and editors by participating in manuscript reviews, facilitating effective communication with reviewers, ensuring the maintenance of quality standards, and collating reviewer comments. Additionally, he will be involved in communicating the final decision to the corresponding author. Together, we endeavor to advance knowledge in this critical area of virology and oncology.

Dr. Hossein H. Ashrafi
Prof. Dr. Mustafa Ozdogan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oncogenesis
  • human papillomavirus (HPV)
  • molecular mechanisms
  • cancer prevention
  • viral oncology
  • novel therapies for HPV-related cancers

Published Papers (2 papers)

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Research

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13 pages, 2117 KiB  
Article
HPV16 E6 Oncogene Contributes to Cancer Immune Evasion by Regulating PD-L1 Expression through a miR-143/HIF-1a Pathway
by Georgios Konstantopoulos, Danai Leventakou, Despoina-Rozi Saltiel, Efthalia Zervoudi, Eirini Logotheti, Spyros Pettas, Korina Karagianni, Angeliki Daiou, Konstantinos E. Hatzistergos, Dimitra Dafou, Minas Arsenakis and Christine Kottaridi
Viruses 2024, 16(1), 113; https://doi.org/10.3390/v16010113 - 12 Jan 2024
Viewed by 1401
Abstract
Human Papillomaviruses have been associated with the occurrence of cervical cancer, the fourth most common cancer that affects women globally, while 70% of cases are caused by infection with the high-risk types HPV16 and HPV18. The integration of these viruses’ oncogenes E6 and [...] Read more.
Human Papillomaviruses have been associated with the occurrence of cervical cancer, the fourth most common cancer that affects women globally, while 70% of cases are caused by infection with the high-risk types HPV16 and HPV18. The integration of these viruses’ oncogenes E6 and E7 into the host’s genome affects a multitude of cellular functions and alters the expression of molecules. The aim of this study was to investigate how these oncogenes contribute to the expression of immune system control molecules, using cell lines with integrated HPV16 genome, before and after knocking out E6 viral gene using the CRISPR/Cas9 system, delivered with a lentiviral vector. The molecules studied are the T-cell inactivating protein PD-L1, its transcription factor HIF-1a and the latter’s negative regulator, miR-143. According to our results, in the E6 knock out (E6KO) cell lines an increased expression of miR-143 was recorded, while a decrease in the expression of HIF-1a and PD-L1 was exhibited. These findings indicate that E6 protein probably plays a significant role in enabling cervical cancer cells to evade the immune system, while we propose a molecular pathway in cervical cancer, where PD-L1’s expression is regulated by E6 protein through a miR-143/HIF-1a axis. Full article
(This article belongs to the Special Issue Papillomavirus-Induced Oncogenesis: Current Insights and Future Directions)
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Review

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16 pages, 1136 KiB  
Review
Unveiling the Role of Human Papillomavirus in Urogenital Carcinogenesis a Comprehensive Review
by Beliz Bahar Karaoğlan and Yüksel Ürün
Viruses 2024, 16(5), 667; https://doi.org/10.3390/v16050667 - 25 Apr 2024
Viewed by 326
Abstract
Human papillomavirus (HPV), an oncogenic DNA virus, is the most common sexually transmitted virus and significant public health concern globally. Despite the substantial prevalence of HPV infection among men, routine testing remains elusive due to the lack of approved HPV tests and the [...] Read more.
Human papillomavirus (HPV), an oncogenic DNA virus, is the most common sexually transmitted virus and significant public health concern globally. Despite the substantial prevalence of HPV infection among men, routine testing remains elusive due to the lack of approved HPV tests and the complexity of detection methods. Various studies have explored the link between HPV and genitourinary cancers, revealing different associations influenced by geographic variation, histological subtype and methodological differences. These findings underscore the importance of further research to elucidate the role of HPV in male urogenital cancers. This comprehensive review delves into the intricate relationship between HPV and male genitourinary cancers, shedding light on the virus’s oncogenic mechanisms and its reported prevalence. A deeper understanding of HPV’s implications for male health is essential for advancing public health initiatives and reducing the burden of urogenital cancers worldwide. Full article
(This article belongs to the Special Issue Papillomavirus-Induced Oncogenesis: Current Insights and Future Directions)
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