Human and Animal Papillomavirus: Infections, Genetics, and Vaccines

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 567

Special Issue Editors


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Guest Editor
Laboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife, Brazil
Interests: nucleic acid vaccine; yeast-based vaccines; application of immunoinformatics in novel vaccine design; development and evaluation of HPV therapeutic; vaccine Zika; viral pathogenesis; Vaccine delivery
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Guest Editor
Laboratory of Molecular Genetics and Biotechnology, Department of Biology, Federal University of Sergipe, São Cristóvão 49100-000, Brazil
Interests: application of bioinformatics; bovine and human papillomavirus; molecular epidemiology; vaccines

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Guest Editor
Federal Institute of Paraíba, Paraíba, Brazil
Interests: bovine and human papillomavirus; molecular epidemiology; oncogenesis; infection biology

Special Issue Information

Dear Colleagues,

Papillomavirus (PV) induces exophytic lesions (papillomas, warts) and flat lesions (flat warts, cervical intraepithelial neoplasia) in cutaneous and mucosal epithelia. The lesions are usually benign and generally regress without eliciting severe clinical problems in the host, but occasionally persist. Persistent lesions can be debilitating and can also provide a focus for malignant transformation, particularly in the presence of environmental or genetic cofactors. Human PV (HPV) encompasses over 200 sequenced, characterized, and cataloged types. In contrast to HPV, Bos taurus papillomavirus (BPV) comprises only a few dozen.

For this Special Issue, we hope experts present exciting advances related to papillomavirus genetics and molecular epidemiology, infection biology, and prophylactic and therapeutic vaccine strategies.

Dr. Antonio Carlos de Freitas
Prof. Dr. Marcus Vinícius de Aragão Batista
Prof. Dr. Maria Angélica Ramos da Silva
Guest Editors

Manuscript Submission Information

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Keywords

  • vaccines
  • infection biology
  • genetics
  • molecular epidemiology
  • bioinformatics
  • oncogenesis
  • HPV and nongenital cancer
  • HPV and cancer
  • animal papillomavirus and associated diseases

Published Papers (1 paper)

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Research

10 pages, 570 KiB  
Article
Monitoring HPV Prevalence and Risk Cofactors for Abnormal Cytology in the Post-Vaccination Period among Croatian Women
by Ena Pešut, Ivana Šimić, Rajko Fureš, Nina Milutin Gašperov, Cvjetko Lež, Fabijan Feratović, Tomica Kukina Žvigač, Magdalena Grce, Ivana Erceg Ivkošić and Ivan Sabol
Viruses 2024, 16(4), 642; https://doi.org/10.3390/v16040642 - 20 Apr 2024
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Abstract
The incidence and mortality rate of cervical cancer in Croatia remains a health challenge despite screening efforts. Besides the persistent infection with HPV, the development of cancer is also associated with some cofactors. The goal of this study was to assess circulating HPV [...] Read more.
The incidence and mortality rate of cervical cancer in Croatia remains a health challenge despite screening efforts. Besides the persistent infection with HPV, the development of cancer is also associated with some cofactors. The goal of this study was to assess circulating HPV genotypes and risk factors for the development of cervical precancer after almost 16 years from the onset of HPV vaccination in Croatia. In this study, a total of 321 women attending gynecological care were evaluated. Relevant medical and demographic information, including cytology, were collected. HPV genotyping was performed by PCR. Comparing the HPV types found in circulation in the pre-vaccination (1999–2015) and post-vaccination periods (2020–2023), a statistically significant reduction in HPV 31 was noted, while the overall prevalence increased in the post-vaccination period. Besides the expected HPV positivity as a risk factor, the history of smoking was associated with LSIL or worse cytology at enrollment. For the first time, this population study revealed a statistically significant shift in the HPV genotype in the post-vaccination period, as well as the confirmation of risk factors for the development of abnormal cytology among Croatian women. Full article
(This article belongs to the Special Issue Human and Animal Papillomavirus: Infections, Genetics, and Vaccines)
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