Virology Research in South Africa—from a Great Legacy to an Optimistic Future

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "General Virology".

Deadline for manuscript submissions: 1 September 2024 | Viewed by 5140

Special Issue Editors


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Guest Editor
Molecular Biology and Virology Research Laboratory, Department of Medical Biosciences, University of the Western Cape, Bellville 7535, South Africa
Interests: human coronaviruses; SARS-CoV; HCoV-NL63; MERS-CoV; SARS-CoV-2; molecular and cell biology
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E-Mail Website
Guest Editor
1. Department of Virology, National Health Laboratory Service, Johannesburg, South Africa
2. Faculty of Health Sciences, Division of Medical Viriology, University of Cape Town, Cape Town, South Africa
Interests: molecular biology; viral phylogenetics; respiratory viruses; influenza; RSV; SARS-CoV-2; CMV; HIV
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We recently published a Viruses Special Issue entitled “State-of-the-Art Virology Research in South Africa”, which has garnered much interest and received numerous submissions. Given the success of the previous Special Issue, we are excited to extend an invitation to our colleagues to participate in a second volume of this Special Issue. The second volume of the Special Issue of the journal Viruses will focus on “Virology Research in South Africa—from a Great Legacy to an Optimistic Future”. As a continuation of the First Volume, this volume aims to provide a comprehensive overview of research on HIV, viral hepatitis, influenza, respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), coronaviruses, other less studied respiratory viruses, zoonotic viruses as well as research on viral vaccines, vaccine development and clinical trials on viral vaccines conducted in South Africa. Other areas relevant to this issue are research related to antiviral resistance for HIV and other viral drugs. This issue is not restricted to research on human viruses, and we invite submission of all virology research from South Africa. This is a great opportunity to showcase all the virus research, and new research niches, that were established due to the SARS-CoV-2 pandemic by South African researchers and their collaborators through submission of original research and review articles.

Prof. Dr. Burtram C. Fielding
Dr. Ziyaad Valley-Omar
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • SARS-CoV-2
  • other respiratory viruses
  • vaccines
  • HIV
  • antiviral resistance
  • zoonotic viruses
  • hepatitis viruses
  • enteric viruses
  • novel viruses/virus discovery

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Published Papers (1 paper)

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20 pages, 2614 KiB  
Hypothesis
Herpesvirus Infection of Endothelial Cells as a Systemic Pathological Axis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
by Jean M. Nunes, Douglas B. Kell and Etheresia Pretorius
Viruses 2024, 16(4), 572; https://doi.org/10.3390/v16040572 - 08 Apr 2024
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Abstract
Understanding the pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is critical for advancing treatment options. This review explores the novel hypothesis that a herpesvirus infection of endothelial cells (ECs) may underlie ME/CFS symptomatology. We review evidence linking herpesviruses to persistent EC infection and [...] Read more.
Understanding the pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is critical for advancing treatment options. This review explores the novel hypothesis that a herpesvirus infection of endothelial cells (ECs) may underlie ME/CFS symptomatology. We review evidence linking herpesviruses to persistent EC infection and the implications for endothelial dysfunction, encompassing blood flow regulation, coagulation, and cognitive impairment—symptoms consistent with ME/CFS and Long COVID. This paper provides a synthesis of current research on herpesvirus latency and reactivation, detailing the impact on ECs and subsequent systemic complications, including latent modulation and long-term maladaptation. We suggest that the chronicity of ME/CFS symptoms and the multisystemic nature of the disease may be partly attributable to herpesvirus-induced endothelial maladaptation. Our conclusions underscore the necessity for further investigation into the prevalence and load of herpesvirus infection within the ECs of ME/CFS patients. This review offers conceptual advances by proposing an endothelial infection model as a systemic mechanism contributing to ME/CFS, steering future research toward potentially unexplored avenues in understanding and treating this complex syndrome. Full article
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