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Viruses
Special Issues
Immune Modulation by Human Cytomegalovirus
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Immune Modulation by Human Cytomegalovirus

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1466

Special Issue Editor

Dr. Davide Abate

E-Mail Website
Guest Editor
Department of Molecular Medicine, University of Padova, 35121 Padua, Italy
Interests: human cytomegalovirus (CMV); herpesviruses; virus-specific T-cell response; transplant infectious diseases

Special Issue Information

Dear Colleagues,

Human cytomegalovirus (CMV) has a large DNA genome (>235Kb) with an incredible capacity for generating viral proteins and regulatory RNAs. In comparison, other DNA viruses, such as human papillomavirus (HPV) or adenovirus (ADV), have genome ranges ranging from 8Kb (HPV) to 30–45Kb (ADV). Differently from many other DNA or RNA viral species, CMV has evolved an incredibly large number of viral products dedicated to controlling the host cell in order to allow viral replication and remain permanently latent within the infected host. In particular, CMV has developed a considerable collection of decoy and deception mechanisms to prevent apoptosis by eluding immune recognition and counteracting intrinsic cellular defences. Some of these mechanisms have been clarified; however, many more piracy mechanisms remain to be elucidated.

This Special Issue will focus on novel and cutting-edge molecular and cellular mechanisms employed by CMV to subvert cell-intrinsic, innate, and adaptive immunity.

Dr. Davide Abate
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • human cytomegalovirus (CMV)
  • molecular and cellular mechanisms
  • cell-intrinsic immunity
  • adaptive immunity
  • innate immunity

Published Papers (1 paper)

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Research

13 pages, 813 KiB  
Article
Genomic Markers Associated with Cytomegalovirus DNAemia in Kidney Transplant Recipients
by Guy Shapira, Hadas Volkov, Itai Fabian, David W. Mohr, Maria Bettinotti, Noam Shomron, Robin K. Avery and Ravit Arav-Boger
Viruses 2023, 15(11), 2227; https://doi.org/10.3390/v15112227 - 08 Nov 2023
Viewed by 1157
Abstract
Human cytomegalovirus (CMV) is a major pathogen after solid organ transplantation, leading to high morbidity and mortality. Transplantation from a CMV-seropositive donor to a CMV-seronegative recipient (D+/R−) is associated with high risk of CMV disease. However, that risk is not uniform, suggesting a [...] Read more.
Human cytomegalovirus (CMV) is a major pathogen after solid organ transplantation, leading to high morbidity and mortality. Transplantation from a CMV-seropositive donor to a CMV-seronegative recipient (D+/R−) is associated with high risk of CMV disease. However, that risk is not uniform, suggesting a role for host factors in immune control of CMV. To identify host genetic factors that control CMV DNAemia post transplantation, we performed a whole-exome association study in two cohorts of D+/R− kidney transplant recipients. Quantitative CMV DNA was measured for at least one year following transplantation. Several CMV-protective single-nucleotide polymorphisms (SNPs) were identified in the first cohort (72 patients) but were not reproducible in the second cohort (126 patients). A meta-analysis of both cohorts revealed several SNPs that were significantly associated with protection from CMV DNAemia. The copy number variation of several genes was significantly different between recipients with and without CMV DNAemia. Amongst patients with CMV DNAemia in the second cohort, several variants of interest (p < 5 × 10−5), the most common of which was NLRC5, were associated with peak viral load. We provide new predictive genetic markers for protection of CMV DNAemia. These markers should be validated in larger cohorts. Full article
(This article belongs to the Special Issue Immune Modulation by Human Cytomegalovirus)
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