Human Norovirus 2024
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 1170
Special Issue Editor
Special Issue Information
Dear Colleagues,
Human norovirus (HuNoV) causes approximately 18% of all gastroenteritis cases in all ages and is recognized as the leading cause of gastroenteritis outbreaks around the world. While the prevalence of HuNoV disease seems to be similar across the continents, an overwhelming majority of HuNoV-associated deaths occur in WHO-defined developing countries. HuNoV disease also has a significant economic impact, with an estimated global economic burden of 60.3 billion dollars per year, including health care costs and productivity loses. Costs due to productivity losses in high-income countries are particularly high.
Concerted efforts to control HuNoV disease face major challenges, including the genetic diversity of viruses and ongoing evolution, strain-restrictive culture systems with low efficiency, and the limited knowledge of host factors that play a role in HuNoV infection, and protective immunity against HuNoV. The periodical emergence of novel HuNoV strains leading to global pandemics is also a major concern. The vast genetic diversity of HuNoV imposes a hurdle for the development of a vaccine that can provide broad coverage across all strains. Global HuNoV surveillance is necessary even after the introduction of vaccines to monitor vaccine effectiveness. In vitro human norovirus culture is an invaluable tool that requires further optimization to support multiple passages, increase permissiveness to more strains, and achieve high virus titers. The current HIE culture system represents a fairly realistic model that allows researchers to study host factors beyond HBGAs, HuNoV entry and infection, and neutralizing antibody responses.
For this Special Issue, we are inviting the submission of papers focusing on both fundamental and applied aspects of norovirus research. Review papers and original research papers are welcome.
Dr. Kosuke Murakami
Guest Editor
Manuscript Submission Information
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Keywords
- virus replication and tropism
- development of cost effective, point-of-care diagnostic assays
- genetic evolution
- pathogenesis
- disinfection
- antivirals and vaccines
- foodborne and waterborne norovirus
Related Special Issue
- Human Norovirus in Viruses (5 articles)
