Rhinoviruses and Asthma
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".
Deadline for manuscript submissions: 1 May 2024 | Viewed by 1593
Special Issue Editor
Special Issue Information
Dear Colleagues,
Rhinoviruses (RVs) are non-enveloped, positive-strand RNA viruses in the genus Enterovirus of the Picornaviridae family, currently classified into 3 species (RV-A, B and C) and 169 types. They replicate their genome and produce progeny in the epithelial cells of human upper and lower respiratory tracts. RVs are among the most frequent causes of viral infections in humans. They can cause a variety of illnesses, including the common cold, lower respiratory tract illnesses such as bronchitis and pneumonia, and exacerbations of asthma, cystic fibrosis and chronic obstructive pulmonary disease. There are currently no specific treatment or prevention options for RV infection. Since the discovery of RVs in the 1950s, clinical isolates of RV-A and RV-B were classified into 100 serotypes in 1987. The third species remained undetected until 2006, because RV-C does not propagate in the cell lines commonly used for virus isolation in vitro due to its lack of cellular receptor expression. RV-A and RV-C isolates are more virulent in children and are more likely to cause exacerbations of childhood asthma compared to RV-B. RV-induced wheezing illnesses in infancy are strongly associated with a high risk of developing asthma in genetically predisposed children; however, the pathogenic mechanisms underlying both asthma inception and exacerbation are not completely understood. This Special Issue welcomes the submission of research and review papers that focus on different aspects of RV biology and its contribution to pathogenesis of asthma, including phylogenetic analysis and epidemiology of RV infections, novel diagnostic methods, virus–host interactions, virus structure and host immune responses, as well as the development of vaccines and antivirals.
Dr. Yury A. Bochkov
Guest Editor
Manuscript Submission Information
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Keywords
- rhinovirus
- epidemiology
- phylogenetic analysis
- immune response
- antibodies
- vaccines
- antivirals
- asthma
- exacerbations
