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Viruses
Special Issues
HPV-Associated Cancers
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HPV-Associated Cancers

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 5169

Special Issue Editors

Prof. Dr. Rui Medeiros

E-Mail Website
Guest Editor
Molecular Oncology and Viral Pathology Group, IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), 4200-072 Porto, Portugal
Interests: HPV; cervical cancer; microrna; cancer
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Hugo Sousa

E-Mail Website
Guest Editor
Molecular Oncology and Viral Pathology Group, IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), 4200-072 Porto, Portugal
Interests: human papillomavirus; herpesvirus; epstein-barr virus; genetic susceptibility; cervical cancer; nasopharyngeal carcinoma; head and neck cancer; gastric cancer

Special Issue Information

Dear Colleagues,

Approximately 10% of worldwide cancers may be attributable to viral infection, which strongly impact the survival and quality of life of affected individuals. Since the identification and characterization of human papillomaviruses (HPVs), an enormous amount of knowledge has been acquired for better understanding the HPV-related disease burden and its associated risk factors, prevention strategies, screening activities, and the onset of immunization programs/vaccination. We must consider that viral diseases, as in the case of HPV, are the result of “pathogen–host–environment” interaction. Epidemiology, diagnosis and treatment studies are critical to the elucidation of the complexity of viral diseases and develop efficient prevention strategies. Cervical cancer is the most studied cancer linked to HPV, but the new trends in research indicate the role of HPV in other cancers as in the case of head and neck and penile cancer. Furthermore, it seems that in the case of head and neck cancer, we must consider HPV not only as a putative etiologic factor in part of the cases, but also as a biomarker of a different biologic behaviour, particularly linked to a better response to therapy compared to non-HPV-associated cancer. Moreover, research has underlined that we must consider HPV in its interaction with the genetic background, epigenetics and tissue environment.

The aim of this Special Issue is to consider the social and public health impact of these diseases and foster discussion and knowledge in the field. The hope is that this Special Issue can contribute to the development of efficient prevention strategies against HPV-associated cancers or better treatment of patients and in accordance with the World Health Assembly’s adopted global strategy to accelerate cervical cancer elimination and other HPV-associated cancers.

Prof. Dr. Rui Medeiros
Prof. Dr. Hugo Sousa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HPV
  • cervical cancer
  • head and neck cancer
  • penile cancer
  • cancer prevention
  • targeted therapy
  • cancer stem cells
  • molecular study
  • carcinogenesis
  • immunotherapy

Published Papers (4 papers)

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Research

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13 pages, 2884 KiB  
Article
From Infection to Malignancy: Tracing the Impact of Human Papillomavirus on Uterine Endometrial Cancer in a Nationwide Population-Based Cohort Study
by Pei-Ju Wu, Stella Chin-Shaw Tsai, Jing-Yang Huang, Maw-Sheng Lee, Po-Hui Wang and Frank Cheau-Feng Lin
Viruses 2023, 15(12), 2314; https://doi.org/10.3390/v15122314 - 25 Nov 2023
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Abstract
Uterine endometrial cancer (EC) is the most common gynecological malignancy in Taiwan. This study aimed to investigate the association between human papillomavirus (HPV) infection and the development of uterine EC among Taiwanese women. A nationwide population cohort research approach was employed, leveraging longitudinal [...] Read more.
Uterine endometrial cancer (EC) is the most common gynecological malignancy in Taiwan. This study aimed to investigate the association between human papillomavirus (HPV) infection and the development of uterine EC among Taiwanese women. A nationwide population cohort research approach was employed, leveraging longitudinal health insurance databases (LHID 2007 and 2015) from the National Health Insurance Research Database alongside data from the Taiwan Cancer Registry datasets. A comparative analysis examined 472,420 female patients with HPV infection and 944,840 without HPV infection. The results demonstrated that the HPV cohort exhibited a significantly elevated risk of uterine EC, as evidenced by an adjusted hazard ratio (aHR) of 1.588 (95% CI: 1.335–1.888). Furthermore, this elevated risk extended to type 1 EC with an aHR of 1.671 (95% CI: 1.376–2.029), specifically the endometrioid adenocarcinoma subtype with an aHR 1.686 (95% CI: 1.377–2.065). Importantly, these findings were statistically significant (p < 0.001). In conclusion, this research unveils a potential association between HPV infection and an increased risk of uterine EC, particularly the type 1 endometrial cancer subtype, within the Taiwanese female population. These findings have implications for preventive measures and screening programs targeting HPV infection to reduce the risk of this prevalent gynecological malignancy in Taiwan. Full article
(This article belongs to the Special Issue HPV-Associated Cancers)
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10 pages, 2371 KiB  
Article
Broad-Spectrum Detection of HPV in Male Genital Samples Using Target-Enriched Whole-Genome Sequencing
by Tengguo Li, Elizabeth R. Unger and Mangalathu S. Rajeevan
Viruses 2023, 15(9), 1967; https://doi.org/10.3390/v15091967 - 21 Sep 2023
Viewed by 862
Abstract
Most human papillomavirus (HPV) surveillance studies target 30–50 of the more than 200 known types. We applied our recently described enriched whole-genome sequencing (eWGS) assay to demonstrate the impact of detecting all known and novel HPV types in male genital samples (n [...] Read more.
Most human papillomavirus (HPV) surveillance studies target 30–50 of the more than 200 known types. We applied our recently described enriched whole-genome sequencing (eWGS) assay to demonstrate the impact of detecting all known and novel HPV types in male genital samples (n = 50). HPV was detected in nearly all (82%) samples, (mean number of types/samples 13.6; range 1–85), and nearly all HPV-positive samples included types in multiple genera (88%). A total of 560 HPV detections (237 unique HPV types: 46 alpha, 55 beta, 135 gamma, and 1 mu types) were made. The most frequently detected HPV types were alpha (HPV90, 43, and 74), beta (HPV115, 195, and 120), and gamma (HPV134, mSD2, and HPV50). High-risk alpha types (HPV16, 18, 31, 39, 52, and 58) were not common. A novel gamma type was identified (now officially HPV229) along with 90 unclassified types. This pilot study demonstrates the utility of the eWGS assay for broad-spectrum type detection and suggests a significantly higher type diversity in males compared to females that warrants further study. Full article
(This article belongs to the Special Issue HPV-Associated Cancers)
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Review

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22 pages, 391 KiB  
Review
HPV and Cervical Cancer: Molecular and Immunological Aspects, Epidemiology and Effect of Vaccination in Latin American Women
by Christian David Hernández-Silva, Adrián Ramírez de Arellano, Ana Laura Pereira-Suárez and Inocencia Guadalupe Ramírez-López
Viruses 2024, 16(3), 327; https://doi.org/10.3390/v16030327 - 21 Feb 2024
Viewed by 1115
Abstract
Cervical cancer is primarily caused by Human Papillomavirus (HPV) infection and remains a significant public health concern, particularly in Latin American regions. This comprehensive narrative review addresses the relationship between Human Papillomavirus (HPV) and cervical cancer, focusing on Latin American women. It explores [...] Read more.
Cervical cancer is primarily caused by Human Papillomavirus (HPV) infection and remains a significant public health concern, particularly in Latin American regions. This comprehensive narrative review addresses the relationship between Human Papillomavirus (HPV) and cervical cancer, focusing on Latin American women. It explores molecular and immunological aspects of HPV infection, its role in cervical cancer development, and the epidemiology in this region, highlighting the prevalence and diversity of HPV genotypes. The impact of vaccination initiatives on cervical cancer rates in Latin America is critically evaluated. The advent of HPV vaccines has presented a significant tool in combating the burden of this malignancy, with notable successes observed in various countries, the latter due to their impact on immune responses. The review synthesizes current knowledge, emphasizes the importance of continued research and strategies for cervical cancer prevention, and underscores the need for ongoing efforts in this field. Full article
(This article belongs to the Special Issue HPV-Associated Cancers)
25 pages, 2536 KiB  
Review
Comparative Analysis of Alpha and Beta HPV E6 Oncoproteins: Insights into Functional Distinctions and Divergent Mechanisms of Pathogenesis
by Josipa Skelin and Vjekoslav Tomaić
Viruses 2023, 15(11), 2253; https://doi.org/10.3390/v15112253 - 14 Nov 2023
Viewed by 1581
Abstract
Human papillomaviruses (HPVs) represent a diverse group of DNA viruses that infect epithelial cells of mucosal and cutaneous tissues, leading to a wide spectrum of clinical outcomes. Among various HPVs, alpha (α) and beta (β) types have garnered significant attention due to their [...] Read more.
Human papillomaviruses (HPVs) represent a diverse group of DNA viruses that infect epithelial cells of mucosal and cutaneous tissues, leading to a wide spectrum of clinical outcomes. Among various HPVs, alpha (α) and beta (β) types have garnered significant attention due to their associations with human health. α-HPVs are primarily linked to infections of the mucosa, with high-risk subtypes, such as HPV16 and HPV18, being the major etiological agents of cervical and oropharyngeal cancers. In contrast, β-HPVs are predominantly associated with cutaneous infections and are commonly found on healthy skin. However, certain β-types, notably HPV5 and HPV8, have been implicated in the development of non-melanoma skin cancers in immunocompromised individuals, highlighting their potential role in pathogenicity. In this review, we comprehensively analyze the similarities and differences between α- and β-HPV E6 oncoproteins, one of the major drivers of viral replication and cellular transformation, and how these impact viral fitness and the capacity to induce malignancy. In particular, we compare the mechanisms these oncoproteins use to modulate common cellular processes—apoptosis, DNA damage repair, cell differentiation, and the immune response—further shedding light on their shared and distinct features, which enable them to replicate at divergent locations of the human body and cause different types of cancer. Full article
(This article belongs to the Special Issue HPV-Associated Cancers)
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