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Recent Advances in Lab-on-a-Chip Devices for Point-of-Care Medical Diagnostics
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Recent Advances in Lab-on-a-Chip Devices for Point-of-Care Medical Diagnostics

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biomedical Sensors".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 3581

Special Issue Editors

Dr. Hung Cao

E-Mail Website
Guest Editor
The Henry Samueli School of Engineering, University of California Irvine, 2200 Engineering Hall, Irvine, CA 92697, USA
Interests: MEMS; BioMEMS; medical devices; neural engineering; cardiovascular engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Anh Hung Nguyen

E-Mail Website
Guest Editor
The Henry Samueli School of Engineering, University of California Irvine, 2200 Engineering Hall, Irvine, CA 92697, USA
Interests: self-assembly of biological and biomimetic nanoscale materials based on amino acids and on nucleic acids using computational and theoretical methods
Special Issues, Collections and Topics in MDPI journals
Dr. Trieu Nguyen

E-Mail Website
Guest Editor
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, California Northstate University, Elk Grove, CA 95757, USA
Interests: point of care diagnostics; lab-on-a-chip; microfluidics; organs-on-chip
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

State-of-the art of lab-on-a-Chip engineering, outbreak, and a burden of cost promote the need for rapid, accurate, sensitive detection techniques used as point-of-Care medical devices. At miniaturized scales, the devices enable to perform diagnostic assays by constructing a high integrated and compact lab-on-a chip system. The core engineering: microfluidic-chip-based technologies, bio and chemical probe synthesis, and sensitive optical and electrochemical detection systems are considered key factors determining performances of lab-on-a-chip medical diagnostic devices. However, there are a misevaluation of their performances in trial and clinical practices due to lack of pieces of full design and fabrication, and clinical evidence for these systems. This special issue is calling for research, review articles, and communication reports in Lab-on-a Chip devices for point-of-care medical diagnostics.

As the guest editors of this Special Issue, we would like to thank the contributors and authors for their valuable time and for submitting papers of high quality. If you have research manuscripts in this field that you would like to publish, please do get in touch.

Dr. Hung Cao
Dr. Anh Hung Nguyen
Dr. Trieu Nguyen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

14 pages, 3645 KiB  
Article
Low-Cost, Real-Time Polymerase Chain Reaction System with Integrated RNA Extraction
by Tchamie Kadja, Yvonne Sun and Vamsy P. Chodavarapu
Sensors 2023, 23(10), 4604; https://doi.org/10.3390/s23104604 - 09 May 2023
Viewed by 1576
Abstract
Rapid, easy-to-use, and low-cost systems for biological sample testing are important for point-of-care diagnostics and various other health applications. The recent pandemic of Coronavirus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) showed an urgent need to rapidly [...] Read more.
Rapid, easy-to-use, and low-cost systems for biological sample testing are important for point-of-care diagnostics and various other health applications. The recent pandemic of Coronavirus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) showed an urgent need to rapidly and accurately identify the genetic material of SARS-CoV-2, an enveloped ribonucleic acid (RNA) virus, in upper respiratory specimens from people. In general, sensitive testing methods require genetic material extraction from the specimen. Unfortunately, current commercially available extraction kits are expensive and involve time-consuming and laborious extraction procedures. To overcome the difficulties associated with common extraction methods, we propose a simple enzymatic assay for the nucleic acid extraction step using heat mediation to improve the polymerase chain reaction (PCR) reaction sensitivity. Our protocol was tested on Human Coronavirus 229E (HCoV-229E) as an example, which comes from the large coronaviridae family of viruses that affect birds, amphibians, and mammals, of which SARS-CoV-2 is a member. The proposed assay was performed using a low-cost, custom-made, real-time PCR system that incorporates thermal cycling and fluorescence detection. It had fully customizable reaction settings to allow versatile biological sample testing for various applications, including point-of-care medical diagnosis, food and water quality testing, and emergency health situations. Our results show that heat-mediated RNA extraction is a viable extraction method when compared to commercial extraction kits. Further, our study showed that extraction has a direct impact on purified laboratory samples of HCoV-229E, but no direct impact on infected human cells. This is clinically relevant, as it allows us to circumvent the extraction step on clinical samples when using PCR. Full article
(This article belongs to the Special Issue Recent Advances in Lab-on-a-Chip Devices for Point-of-Care Medical Diagnostics)
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11 pages, 1661 KiB  
Article
Portable Surface Plasmon Resonance Detector for COVID-19 Infection
by Maciej Trzaskowski, Anna Mazurkiewicz-Pisarek, Jakub Waldemar Trzciński, Marcin Drozd, Rafał Podgórski, Anna Zabost and Ewa Augustynowicz-Kopeć
Sensors 2023, 23(8), 3946; https://doi.org/10.3390/s23083946 - 13 Apr 2023
Cited by 3 | Viewed by 1607
Abstract
Methods based on nucleic acid detection are currently the most commonly used technique in COVID-19 diagnostics. Although generally considered adequate, these methods are characterised by quite a long time-to-result and the necessity to prepare the material taken from the examined person—RNA isolation. For [...] Read more.
Methods based on nucleic acid detection are currently the most commonly used technique in COVID-19 diagnostics. Although generally considered adequate, these methods are characterised by quite a long time-to-result and the necessity to prepare the material taken from the examined person—RNA isolation. For this reason, new detection methods are being sought, especially those characterised by the high speed of the analysis process from the moment of sampling to the result. Currently, serological methods of detecting antibodies against the virus in the patient’s blood plasma have attracted much attention. Although they are less precise in determining the current infection, such methods shorten the analysis time to several minutes, making it possible to consider them a promising method for screening tests in people with suspected infection. The described study investigated the feasibility of a surface plasmon resonance (SPR)-based detection system for on-site COVID-19 diagnostics. A simple-to-use portable device was proposed for the fast detection of anti-SARS-CoV-2 antibodies in human plasma. SARS-CoV-2-positive and -negative patient blood plasma samples were investigated and compared with the ELISA test. The receptor-binding domain (RBD) of spike protein from SARS-CoV-2 was selected as a binding molecule for the study. Then, the process of antibody detection using this peptide was examined under laboratory conditions on a commercially available SPR device. The portable device was prepared and tested on plasma samples from humans. The results were compared with those obtained in the same patients using the reference diagnostic method. The detection system is effective in the detection of anti-SARS-CoV-2 with the detection limit of 40 ng/mL. It was shown that it is a portable device that can correctly examine human plasma samples within a 10 min timeframe. Full article
(This article belongs to the Special Issue Recent Advances in Lab-on-a-Chip Devices for Point-of-Care Medical Diagnostics)
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