Microfluidics for Pharmaceutical Applications

Topic Information

Dear Colleagues,

In this topic, we aim to draw the interest of scientists in the microfluidic applications in the field of pharmacy. Microfluidics has been a renowned topic for the last three decades. The variety of applications of microfluidics, from biology to physics and chemistry, has been an interest of both academia and industry in recent years. In this topic, we aim to address the microfluidic applications in pharmacy. Authors can send their manuscripts to several high-impact journals included in this topic, such as Biosensors, Future Pharmacology, Micromachines, Pharmaceuticals, and Pharmaceutics. Here, we list some of the keywords ( but not limited to) which can be the main focus of the submitted manuscripts, namely: organ-on-chip, human-on-chip, drug delivery, nanotechnology, pharmacokinetics, drug screening, cancer, optical detections, diagnostics, point-of-care, bioanalysis, tissue chip, biochip, microfluidics, nanofluidics, microfabrication, nanofabrication, commercialization, rapid detection, early detection, personalized medicine, artificial intelligence, health intelligence, machine learning for health applications, data mining, and biosensors. As the topic editor of this Special Topic, we would like to thank the contributors for their valuable time and for submitting papers of high quality. If you have any research in this field that you would like to publish, please get in touch.

Dr. Trieu Nguyen
Prof. Dr. Dang Duong Bang
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Biosensors biosensors	5.4	4.9	2011	17.4 Days	CHF 2700
Future Pharmacology futurepharmacol	-	-	2021	20.5 Days	CHF 1000
Micromachines micromachines	3.4	4.7	2010	16.1 Days	CHF 2600
Pharmaceuticals pharmaceuticals	4.6	4.7	2004	14.6 Days	CHF 2900
Pharmaceutics pharmaceutics	5.4	6.9	2009	14.2 Days	CHF 2900

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Published Papers (2 papers)

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All Biosensors Future Pharmacology Micromachines Pharmaceuticals Pharmaceutics

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24 pages, 4017 KiB  

Open AccessReview

Combining 3D Printing and Microfluidic Techniques: A Powerful Synergy for Nanomedicine

by Federica Sommonte, Nunzio Denora and Dimitrios A. Lamprou

Pharmaceuticals 2023, 16(1), 69; https://doi.org/10.3390/ph16010069 - 01 Jan 2023

Cited by 11 | Viewed by 3480

Abstract

Nanomedicine has grown tremendously in recent years as a responsive strategy to find novel therapies for treating challenging pathological conditions. As a result, there is an urgent need to develop novel formulations capable of providing adequate therapeutic treatment while overcoming the limitations of [...] Read more.

Nanomedicine has grown tremendously in recent years as a responsive strategy to find novel therapies for treating challenging pathological conditions. As a result, there is an urgent need to develop novel formulations capable of providing adequate therapeutic treatment while overcoming the limitations of traditional protocols. Lately, microfluidic technology (MF) and additive manufacturing (AM) have both acquired popularity, bringing numerous benefits to a wide range of life science applications. There have been numerous benefits and drawbacks of MF and AM as distinct techniques, with case studies showing how the careful optimization of operational parameters enables them to overcome existing limitations. Therefore, the focus of this review was to highlight the potential of the synergy between MF and AM, emphasizing the significant benefits that this collaboration could entail. The combination of the techniques ensures the full customization of MF-based systems while remaining cost-effective and less time-consuming compared to classical approaches. Furthermore, MF and AM enable highly sustainable procedures suitable for industrial scale-out, leading to one of the most promising innovations of the near future. Full article

(This article belongs to the Topic Microfluidics for Pharmaceutical Applications)

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10 pages, 2337 KiB  

Open AccessArticle

Flow Synthesis of L-α-Glycerylphosphorylcholine: Studies on Synthetic Routes Applicable to a Flow Reactor and Optimization of Reaction Conditions

by Jihun Park, Seungjae Lee, Gyungtak Kim, Yashwardhan R. Malpani, Boyoung Y. Park and Ye-Jin Hwang

Pharmaceutics 2022, 14(11), 2480; https://doi.org/10.3390/pharmaceutics14112480 - 16 Nov 2022

Viewed by 1478

Abstract

L-α-Glycerylphosphorylcholine (L-α-GPC) has mainly been produced by two methods: extraction from plants rich in phosphatidylcholine and chemical synthesis. However, production through extraction involves difficult processes, such as fermentation, extractions and ripening, and conventional chemical synthesis methods with high-cost reactants and a batch reactor. [...] Read more.

L-α-Glycerylphosphorylcholine (L-α-GPC) has mainly been produced by two methods: extraction from plants rich in phosphatidylcholine and chemical synthesis. However, production through extraction involves difficult processes, such as fermentation, extractions and ripening, and conventional chemical synthesis methods with high-cost reactants and a batch reactor. These methods are not ideal for large-quantity production. Thus, it is important to develop a simple production method of L-α-GPC, which is suitable for mass production without the need for expensive reactants. Here, we studied synthetic L-α-GPC methods that are applicable to a flow synthesis system, which can provide selectivity, reproducibility, scalability, and a high yield in short reaction time using inexpensive starting materials. We developed a two-step synthetic route to produce L-α-GPC, including the synthesis of phosphoryl choline using choline chloride and phosphoryl oxychloride (POCl₃) as a first step and synthesis of L-α-GPC by reacting phosphoryl choline with (R)-($-$)-3-chloro-1,2-propanediol (CPD) as a second step under basic conditions. Both steps were separately performed in a customized flow reactor, and reaction conditions were optimized. Finally, phosphoryl choline and L-α-GPC, the products first and second reactions, were successfully synthesized with high conversion yields of 97% and 79%, respectively. Full article

(This article belongs to the Topic Microfluidics for Pharmaceutical Applications)

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