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Polymers
Special Issues
Polymer Based Biomaterials
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Special Issue "Polymer Based Biomaterials"

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 6046

Special Issue Editor

Dr. Yasutaka Anraku
E-Mail Website
Guest Editor
Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
Interests: drug delivery system; biomaterial
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, there has been an increase in the number of studies of polymeric materials related to bottom-up nanotechnologies due to their great potential in the development of biomedical applications. The objective of this Special Issue is to deepen our knowledge on polymeric materials for biomedical applications from broad viewpoints. Its scope encompasses the design and synthesis of polymers, the development and characterization of polymeric materials, and the elucidation of processes involved in a variety of in vivo phenomena, such as blood circulation and biodistribution profiles. While the articles in this issue do not necessarily need to report novel polymeric materials, they should provide novel insights into biomedical applications.

Prof. Dr. Yasutaka Anraku
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Polymers
  • Polymeric materials
  • Biomedical applications

Published Papers (2 papers)

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Research

17 pages, 6457 KiB  
Article
Preparation and Characterization of Ionic Conductive Poly(acrylic Acid)-Based Silicone Hydrogels for Smart Drug Delivery System
by
Young-Ah Kim
,
Jin-Oh Jeong
and
Jong-Seok Park
Polymers 2021, 13(3), 406; https://doi.org/10.3390/polym13030406 - 27 Jan 2021
Cited by 8 | Viewed by 2905
Abstract
In this study, we developed a smart drug delivery system that can efficiently deliver the required amounts of drugs using the excellent ion conductivity of poly(acrylic acid) (PAA) and an electrical stimulus. As a result of its having carboxyl groups, PAA hydrogel can [...] Read more.
In this study, we developed a smart drug delivery system that can efficiently deliver the required amounts of drugs using the excellent ion conductivity of poly(acrylic acid) (PAA) and an electrical stimulus. As a result of its having carboxyl groups, PAA hydrogel can be used in drug delivery patches to release drugs by ionic conductivity. However, PAA hydrogel has low durability and poor mechanical properties. The carboxyl group of PAA was combined with a siloxane group of silicone using electron-beam irradiation to easily form a crosslinked structure. The PAA–silicone hydrogel has excellent mechanical properties. Specifically, the tensile strength increased more than 3.5 times. In addition, we observed its cell compatibility using fluorescence staining and CCK-8 assays and found good cell viability. Finally, it was possible to control the drug delivery rate efficiently using the voltage applied to the ion-conductive hydrogel. As the voltage was increased to 3, 5, and 7 V, the amount of drug released was 53, 88, and 96%, respectively. These excellent properties of the PAA–silicone hydrogel can be used not only for whitening or anti-wrinkling cosmetics but also in medical drug-delivery systems. Full article
(This article belongs to the Special Issue Polymer Based Biomaterials)
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Graphical abstract

9 pages, 2618 KiB  
Communication
Effect of Mixing Ratio of Oppositely Charged Block Copolymers on Polyion Complex Micelles for In Vivo Application
by
Noriko Nakamura
,
Yuki Mochida
,
Kazuko Toh
,
Shigeto Fukushima
,
Horacio Cabral
and
Yasutaka Anraku
Polymers 2021, 13(1), 5; https://doi.org/10.3390/polym13010005 - 22 Dec 2020
Cited by 9 | Viewed by 2498
Abstract
Self-assembled supramolecular structures based on polyion complex (PIC) formation between oppositely charged polymers are attracting much attention for developing drug delivery systems able to endure harsh in vivo environments. As controlling polymer complexation provides an opportunity for engineering the assemblies, an improved understanding [...] Read more.
Self-assembled supramolecular structures based on polyion complex (PIC) formation between oppositely charged polymers are attracting much attention for developing drug delivery systems able to endure harsh in vivo environments. As controlling polymer complexation provides an opportunity for engineering the assemblies, an improved understanding of the PIC formation will allow constructing assemblies with enhanced structural and functional capabilities. Here, we focused on the influence of the mixing charge ratio between block aniomers and catiomers on the physicochemical characteristics and in vivo biological performance of the resulting PIC micelles (PIC/m). Our results showed that by changing the mixing charge ratio, the structural state of the core was altered despite the sizes of PIC/m remaining almost the same. These structural variations greatly affected the stability of the PIC/m in the bloodstream after intravenous injection and determined their biodistribution. Full article
(This article belongs to the Special Issue Polymer Based Biomaterials)
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