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Polymers
Special Issues
Exploitation of Polymer Structure and Mechanics in Developing Medicines
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Exploitation of Polymer Structure and Mechanics in Developing Medicines

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (20 August 2022) | Viewed by 2999

Special Issue Editor

Dr. Muhammad Usman Ghori

E-Mail Website
Guest Editor
School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, UK
Interests: biopolymers; carbohydrate polymers; polysaccharides; sustainable materials; surface topography; material mechanical and compaction properties; 3D and 4D printing; imaging algorithms; atomic force microscopy; powder technology; electrostatic charging; pharmaceutical formulations

Special Issue Information

Dear Colleagues,

The last few decades have witnessed extensive exploitation of polymers in designing and manufacturing of medicines. The structure and mechanical characteristics of these polymer chains enable them to achieve the desired therapeutic objectives. For example, the use of polymers in developing 3D and 4D printed, age-appropriate, technology-driven control release, targeted and electrically triggered medicines. However, the selection of polymeric materials in accordance with the clinical application is an emerging area that requires attention.

This Special Issue aims to comprehend recent polymer advances in the design and fabrication of polymer-based medicines.

It is our pleasure to invite you to contribute a manuscript to this Special Issue. Full research papers, short communications, and reviews are all welcome.

The list of keywords below is not exhaustive, but it may help in preparing your submission. Please do not hesitate to go beyond it or to submit a paper whose topic is not explicitly mentioned in this list

Dr. Muhammad Usman Ghori
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Mechanical properties of polymers
  • Powder technology
  • Physicochemical and structural characterization
  • Age-appropriate and targeted medicines
  • Additively manufactured (3D and 4D) medicines
  • Polymer characterization
  • Electrically triggered medicines

Published Papers (1 paper)

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Research

15 pages, 3371 KiB  
Article
Personalised 3D Printed Fast-Dissolving Tablets for Managing Hypertensive Crisis: In-Vitro/In-Vivo Studies
by Amjad Hussain, Faisal Mahmood, Muhammad Sohail Arshad, Nasir Abbas, Nadia Qamar, Jahanzeb Mudassir, Samia Farhaj, Jorabar Singh Nirwan and Muhammad Usman Ghori
Polymers 2020, 12(12), 3057; https://doi.org/10.3390/polym12123057 - 20 Dec 2020
Cited by 16 | Viewed by 3114
Abstract
Hypertensive crisis (HC) is an emergency health condition which requires an effective management strategy. Over the years, various researchers have developed captopril based fast-dissolving formulations to manage HC; however, primarily, the question of personalisation remains unaddressed. Moreover, commercially these formulations are available as [...] Read more.
Hypertensive crisis (HC) is an emergency health condition which requires an effective management strategy. Over the years, various researchers have developed captopril based fast-dissolving formulations to manage HC; however, primarily, the question of personalisation remains unaddressed. Moreover, commercially these formulations are available as in fixed-dose combinations or strengths, so the titration of dose according to patient’s prerequisite is challenging to achieve. The recent emergence of 3D printing technologies has given pharmaceutical scientists a way forward to develop personalised medicines keeping in view patients individual needs. The current project, therefore, is aimed at addressing the limitations as mentioned above by developing fast-dissolving captopril tablets using 3D printing approach. Captopril unloaded (F1) and loaded (F2-F4) filaments were successfully produced with an acceptable drug loading and mechanical properties. Various captopril formulations (F2–F4) were successfully printed using fused deposition modelling technique. The results revealed that the formulations (F2 and F3) containing superdisintegrant had a faster extent of dissolution and in-vivo findings were endorsing these results. The present study has successfully exhibited the utilisation of additive manufacturing approach to mend the gap of personalisation and manufacturing fast-dissolving captopril 3D printed tablets. The procedure adopted in the present study may be used for the development of fused deposition modelling (FDM) based fast-dissolving 3D printed tablets. Full article
(This article belongs to the Special Issue Exploitation of Polymer Structure and Mechanics in Developing Medicines)
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