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Polymers
Special Issues
Polymeric Drugs and Drug Delivery Systems
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Polymeric Drugs and Drug Delivery Systems

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Networks".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 7944

Special Issue Editors

Dr. Bruno Henrique Vilsinski

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Guest Editor
Group of Biopolymeric Materials and Composites (GBMC), Campus Universitário, Federal University of Juiz de Fora, Rua José Lourenço Kelmer, s/n-São Pedro, Juiz de Fora 36036-900, MG, Brazil
Interests: polymers; drug delivery systems; nanocarriers; hydrogels; micelles; dendrimers; adhesives; cyclodextrins; polyelectrolite multilayers
Special Issues, Collections and Topics in MDPI journals
Dr. Dina Maria Bairrada Murtinho

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Guest Editor
Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal
Interests: organic synthesis: synthesis of chiral ligands; asymmetric catalysis; polymer chemistry
Prof. Dr. Artur J. M. Valente

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Guest Editor
Department of Chemistry, Universidade de Coimbra, Coimbra, Portugal
Interests: drug delivery systems; polymer-based nanocomposites; biopolymers; synthetic polymers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is a great pleasure to present this Special Issue, entitled “Polymeric Drugs and Drug Delivery Systems”, which will allow polymer researchers to submit research papers and reviews on this topic.

Natural and synthetic polymers have been extensively used to obtain drug delivery systems (DDSs). Examples of relevant DDSs involve polymeric micelles, liposomes, hydrogels, polyelectrolyte complexes, nanoparticles, dendrimers, and bioadhesives. The main objective of these systems is to protect drugs from degradation, improve their bioavailability, and decrease their harmful effects. Each DDS has particular properties depending on the original polymer obtained.

This Special Issue invites researchers to submit papers concerning polymers and biopolymer-based composites, highlighting recent progress in their synthesis, characterization, and potential implications.

Dr. Bruno Henrique Vilsinski
Dr. Dina Maria Bairrada Murtinho
Prof. Dr. Artur Valente
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery systems
  • polymer-based nanocomposites
  • biopolymers
  • synthetic polymers

Published Papers (2 papers)

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Research

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13 pages, 4260 KiB  
Article
Biocompatible Polymer-Grafted TiO2 Nanoparticle Sonosensitizers Prepared Using Phosphonic Acid-Functionalized RAFT Agent
by Yukiya Kitayama, Aoi Katayama, Zhicheng Shao and Atsushi Harada
Polymers 2023, 15(11), 2426; https://doi.org/10.3390/polym15112426 - 23 May 2023
Viewed by 1341
Abstract
Sonodynamic therapy is widely used in clinical studies including cancer therapy. The development of sonosensitizers is important for enhancing the generation of reactive oxygen species (ROS) under sonication. Herein, we have developed poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-modified TiO2 nanoparticles as new biocompatible sonosensitizers with [...] Read more.
Sonodynamic therapy is widely used in clinical studies including cancer therapy. The development of sonosensitizers is important for enhancing the generation of reactive oxygen species (ROS) under sonication. Herein, we have developed poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-modified TiO2 nanoparticles as new biocompatible sonosensitizers with high colloidal stability under physiological conditions. To fabricate biocompatible sonosensitizers, a grafting-to approach was adopted with phosphonic-acid-functionalized PMPC, which was prepared by reversible addition–fragmentation chain transfer (RAFT) polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) using a newly designed water-soluble RAFT agent possessing a phosphonic acid group. The phosphonic acid group can conjugate with the OH groups on the TiO2 nanoparticles. We have clarified that the phosphonic acid end group is more crucial for creating colloidally stable PMPC-modified TiO2 nanoparticles under physiological conditions than carboxylic-acid-functionalized PMPC-modified ones. Furthermore, the enhanced generation of singlet oxygen (1O2), an ROS, in the presence of PMPC-modified TiO2 nanoparticles was confirmed using a 1O2-reactive fluorescent probe. We believe that the PMPC-modified TiO2 nanoparticles prepared herein have potential utility as novel biocompatible sonosensitizers for cancer therapy. Full article
(This article belongs to the Special Issue Polymeric Drugs and Drug Delivery Systems)
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Review

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27 pages, 3064 KiB  
Review
Pharmaceutical Coating and Its Different Approaches, a Review
by Ahmad Salawi
Polymers 2022, 14(16), 3318; https://doi.org/10.3390/polym14163318 - 15 Aug 2022
Cited by 21 | Viewed by 5976
Abstract
Coating the solid dosage form, such as tablets, is considered common, but it is a critical process that provides different characteristics to tablets. It increases the value of solid dosage form, administered orally, and thus meets diverse clinical requirements. As tablet coating is [...] Read more.
Coating the solid dosage form, such as tablets, is considered common, but it is a critical process that provides different characteristics to tablets. It increases the value of solid dosage form, administered orally, and thus meets diverse clinical requirements. As tablet coating is a process driven by technology, it relies on advancements in coating techniques, equipment used for the coating process, evaluation of coated tablets, and coated material used. Although different techniques were employed for coating purposes, which may be based on the use of solvents or solvent-free, each of the methods used has its advantages and disadvantages, and the techniques need continued modification too. During the process of film coating, several inter-and intra-batch uniformity of coated material on the tablets is considered a critical point that ensures the worth of the final product, particularly for those drugs that contain an active medicament in the coating layer. Meanwhile, computational modeling and experimental evaluation were actively used to predict the impact of the operational parameters on the final product quality and optimize the variables in tablet coating. The efforts produced by computational modeling or experimental evaluation not only save cost in optimizing the coating process but also saves time. This review delivers a brief review on film coating in solid dosage form, which includes tablets, with a focus on the polymers and processes used in the coating. At the end, some pharmaceutical applications were also discussed. Full article
(This article belongs to the Special Issue Polymeric Drugs and Drug Delivery Systems)
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