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Polymers
Special Issues
Biopolymers for Drug Delivery and Tissue Engineering
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Biopolymers for Drug Delivery and Tissue Engineering

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 6281

Special Issue Editors

Dr. Jasmin Monpara

E-Mail Website
Guest Editor
Department of Pharmacetical Sciences, Saint Joseph’s University, Philadelphia, PA, USA
Interests: liposomes; targeted drug delivery; controlled release; polymeric nanoparticles
Dr. Pardeep K. Gupta

E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, Saint Joseph’s University, Philadelphia, PA, USA
Interests: controlled release; protein delivery; targeted drug delivery
Dr. Gagan Kaushal

E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, Thomas Jefferson University, Philadelphia, PA, USA
Interests: drug delivery; hydrogels; pharmacokinetics and dynamics (PK/PD)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural and synthetic biomaterials have been extensively utilized in drug delivery and tissue engineering applications. The versatility of biomaterials has allowed researchers to modulate their physicochemical properties to achieve desired behavior in vivo, such as the stimuli-responsive release of the encapsulated therapeutic agent or controlled release of the active agent at a predetermined rate. Conjugated biomaterials allow tissue-specific targeting of the active agent, thereby improving therapeutic effectiveness and reducing off-target effects. Hydrogel-forming biomaterials have shown tremendous success in tissue engineering, 3D bioprinting, and drug delivery. The nano or microparticles resulting from the self-assembly of biomaterials have proven efficacy in treating or diagnosing various diseases, including cancer, viral infections, Alzheimer's disease, etc.

Considering the rapid advancement of the field, we invite researchers to contribute a short review, full review, short communication, research manuscript, or letter to the editor in the biomaterial-based advanced drug delivery systems field for the treatment or diagnosis of chronic or acute disease. We invite researchers involved in synthesizing and characterizing novel biomaterials for potential drug delivery or tissue engineering application to contribute to this Special Issue. Clinical investigators and pharmacologists involved in evaluating toxicity/biocompatibility of novel biomaterials, pharmacokinetics/pharmacodynamics of biomaterial-based systems, or modeling of release from biomaterials are also requested to contribute to this issue.

Dr. Jasmin Monpara
Dr. Pardeep K. Gupta
Dr. Gagan Kaushal
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • hydrogel
  • controlled-release
  • microparticles
  • 3D-bioprinting
  • targeted drug delivery
  • biocompatible polymers
  • natural polymers
  • synthetic biopolymers

Published Papers (4 papers)

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Research

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12 pages, 7737 KiB  
Article
Strong Bioactive Glass-Based Hybrid Implants with Good Biomineralization Activity Used to Reduce Formation Duration and Improve Biomechanics of Bone Regeneration
by Jing Chen, Yonglei Xing, Xiaozhuan Bai, Min Xue, Qi Shi and Beibei Li
Polymers 2023, 15(17), 3497; https://doi.org/10.3390/polym15173497 - 22 Aug 2023
Cited by 2 | Viewed by 708
Abstract
Developing bioactive implants with strong mechanical properties and biomineralization activity is critical in bone repair. In this work, modified cellulose nanofiber (mCNF)-reinforced bioactive glass (BG)-polycaprolactone (PCL) hybrids (mCNF–BP) with strong biomechanics and good apatite formation ability were reported. Incorporating mCNFs shortens the forming [...] Read more.
Developing bioactive implants with strong mechanical properties and biomineralization activity is critical in bone repair. In this work, modified cellulose nanofiber (mCNF)-reinforced bioactive glass (BG)-polycaprolactone (PCL) hybrids (mCNF–BP) with strong biomechanics and good apatite formation ability were reported. Incorporating mCNFs shortens the forming duration of the hybrid films and enhances the biomechanical performance and in vitro apatite-formation capability. The optimized biomechanical performance of the optimal hybrid materials is produced at a relatively high mCNF content (1.0 wt%), including a considerably higher modulus of elasticity (948.65 ± 74.06 MPa). In addition, the biomineralization activity of mCNF–BP hybrids is also tailored with the increase in the mCNF contents. The mCNF–BP with 1.5 wt% and 2.0 wt% mCNFs demonstrate the best biomineralization activity after immersing in simulated body fluid for 3 days. This study suggests that mCNFs are efficient bioactive additive to reinforce BG-based hybrids’ mechanical properties and biomineralization activity. Full article
(This article belongs to the Special Issue Biopolymers for Drug Delivery and Tissue Engineering)
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12 pages, 2927 KiB  
Article
Fabrication and Validation of a 3D Portable PEGDA Microfluidic Chip for Visual Colorimetric Detection of Captured Breast Cancer Cells
by Mingyi Guo, Yan Deng, Junqiu Huang, Yanping Huang, Jing Deng and Huachang Wu
Polymers 2023, 15(15), 3183; https://doi.org/10.3390/polym15153183 - 27 Jul 2023
Cited by 1 | Viewed by 1527
Abstract
To guide therapeutic strategies and to monitor the state changes in the disease, a low-cost, portable, and easily fabricated microfluidic-chip-integrated three-dimensional (3D) microchamber was designed for capturing and analyzing breast cancer cells. Optimally, a colorimetric sensor array was integrated into a microfluidic chip [...] Read more.
To guide therapeutic strategies and to monitor the state changes in the disease, a low-cost, portable, and easily fabricated microfluidic-chip-integrated three-dimensional (3D) microchamber was designed for capturing and analyzing breast cancer cells. Optimally, a colorimetric sensor array was integrated into a microfluidic chip to discriminate the metabolites of the cells. The ultraviolet polymerization characteristic of poly(ethylene glycol) diacrylate (PEGDA) hydrogel was utilized to rapidly fabricate a three-layer hydrogel microfluidic chip with the designed structure under noninvasive 365 nm laser irradiation. 2-Hydroxyethyl methacrylate (HEMA) was added to the prepolymer in order to increase the adhesive capacity of the microchip’s surface for capturing cells. 1-Vinyl-2-pyrrolidone (NVP) was designed to improve the toughness and reduce the swelling capacity of the hydrogel composite. A non-toxic 3D hydrogel microarray chip (60 mm × 20 mm × 3 mm) with low immunogenicity and high hydrophilicity was created to simulate the real physiological microenvironment of breast tissue. The crisscross channels were designed to ensure homogeneous seeding density. This hydrogel material displayed excellent biocompatibility and tunable physical properties compared with traditional microfluidic chip materials and can be directly processed to obtain the most desirable microstructure. The feasibility of using a PEGDA hydrogel microfluidic chip for the real-time online detection of breast cancer cells’ metabolism was confirmed using a specifically designed colorimetric sensor array with 16 kinds of porphyrin, porphyrin derivatives, and indicator dyes. The results of the principal component analysis (PCA), the hierarchical cluster analysis (HCA), and the linear discriminant analysis (LDA) suggest that the metabolic liquids of different breast cells can be easily distinguished with the developed PEGDA hydrogel microfluidic chip. The PEGDA hydrogel microfluidic chip has potential practicable applicability in distinguishing normal and cancerous breast cells. Full article
(This article belongs to the Special Issue Biopolymers for Drug Delivery and Tissue Engineering)
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21 pages, 6879 KiB  
Article
Optimization of a Mucoadhesive Vaginal Gel Containing Clotrimazole Using a D-Optimal Experimental Design and Multivariate Analysis
by Elena Dinte, Rares Iuliu Iovanov, Andreea Elena Bodoki, Ioana Alina Colosi, Horatiu Alexandru Colosi, Nicoleta Tosa, Oliviu Vostinaru and Ioan Tomuta
Polymers 2023, 15(9), 2023; https://doi.org/10.3390/polym15092023 - 24 Apr 2023
Viewed by 1086
Abstract
The aim of this study was to develop a suitable clotrimazole (CLT)-loaded mucoadhesive vaginal gel (CLT-MVG) for topical applications in vaginal candidiasis. Ten CLT-MVG formulations were prepared, consisting of mixtures of acid polyacrylic (Carbopol 940) and polyethene oxides, Sentry Polyox WSRN 1105 or [...] Read more.
The aim of this study was to develop a suitable clotrimazole (CLT)-loaded mucoadhesive vaginal gel (CLT-MVG) for topical applications in vaginal candidiasis. Ten CLT-MVG formulations were prepared, consisting of mixtures of acid polyacrylic (Carbopol 940) and polyethene oxides, Sentry Polyox WSRN 1105 or 750, according to an experimental D-optimal design, and CLT was suspended at a ratio of 1%. The prepared CLT-MVG formulations were studied in vitro, and the formulation containing Carbopol 940 0.89% combined with PEO 1105 1.39% was identified with the optimal rheological and in vitro bioadhesion properties, ensuring the prolonged release of CLT, with a similarity factor greater than 50, indicating dissolution profile similarity for three batches of the optimized formulation. This optimized formulation showed a pH in the tolerance range, and an adequate ex vivo mucoadhesion time, while the FT-IR studies revealed no interactions between the excipients and CLT. The microscopic analysis identified a mean particle size of suspended CLT of 5.24 ± 0.57 μm. The in vitro antifungal activity of the optimized formulation was tested on twenty strains of Candida albicans and proved to be better compared to a marketed clotrimazole preparation, showing a greater inhibition effect (p < 0.05). The optimized formulation could be a good candidate for the local treatment of vaginal mycosis. Full article
(This article belongs to the Special Issue Biopolymers for Drug Delivery and Tissue Engineering)
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Review

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18 pages, 1788 KiB  
Review
Emulgels: Promising Carrier Systems for Food Ingredients and Drugs
by Jovana Milutinov, Veljko Krstonošić, Dejan Ćirin and Nebojša Pavlović
Polymers 2023, 15(10), 2302; https://doi.org/10.3390/polym15102302 - 13 May 2023
Cited by 8 | Viewed by 2508
Abstract
Novel delivery systems for cosmetics, drugs, and food ingredients are of great scientific and industrial interest due to their ability to incorporate and protect active substances, thus improving their selectivity, bioavailability, and efficacy. Emulgels are emerging carrier systems that represent a mixture of [...] Read more.
Novel delivery systems for cosmetics, drugs, and food ingredients are of great scientific and industrial interest due to their ability to incorporate and protect active substances, thus improving their selectivity, bioavailability, and efficacy. Emulgels are emerging carrier systems that represent a mixture of emulsion and gel, which are particularly significant for the delivery of hydrophobic substances. However, the proper selection of main constituents determines the stability and efficacy of emulgels. Emulgels are dual-controlled release systems, where the oil phase is utilized as a carrier for hydrophobic substances and it determines the occlusive and sensory properties of the product. The emulsifiers are used to promote emulsification during production and to ensure emulsion stability. The choice of emulsifying agents is based on their capacity to emulsify, their toxicity, and their route of administration. Generally, gelling agents are used to increase the consistency of formulation and improve sensory properties by making these systems thixotropic. The gelling agents also impact the release of active substances from the formulation and stability of the system. Therefore, the aim of this review is to gain new insights into emulgel formulations, including the components selection, methods of preparation, and characterization, which are based on recent advances in research studies. Full article
(This article belongs to the Special Issue Biopolymers for Drug Delivery and Tissue Engineering)
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