Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.6
5.0
Journals
Polymers
Special Issues
Hydrogel Materials for Drug Delivery and Tissue Engineering
share announcement

Hydrogel Materials for Drug Delivery and Tissue Engineering

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 25 July 2024 | Viewed by 5127

Special Issue Editors

Dr. Aneta Ostróżka-Cieślik

E-Mail Website
Guest Editor
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, Poland
Interests: drug form technology; new drug carriers; preformulation and formulation studies; manufacturing process of liquid; semisolid and solid dosage forms
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Sławomir Wilczyński

E-Mail Website
Guest Editor
Department of Basic Biomedical Science, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, Poland
Interests: pharmacy; topical drug delivery; image analysis and processing; thermography; hyperspectral imaging; biomedical engineering; bioengineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Research into hydrogels and the possibility of using them for pharmaceutical and biomedical applications is one of science's most intensively developing areas. Modern hydrogel materials are structured to resemble the natural environment of cells and tissues and they are thus used in the design of effective drug carriers, surgical fillers, and cell culture media. This Special Issue will be devoted to the analysis of the physicochemical, biopharmaceutical, and mechanical properties of hydrogels with potential applications in drug delivery, tissue engineering, and regenerative medicine. Current research directions in the areas of pharmaceutical technology, polymer materials engineering, and biomedical engineering will be discussed. Our aim is to collect original papers, review papers on the development of hydrogels and hydrogel systems that can carry an active substance or can replace damaged tissues or organs. Basic, pre-clinical, and clinical research on the development of new or the development of existing hydrogel-based drugs and therapies is welcome. 

Dr. Aneta Ostróżka-Cieślik
Prof. Dr. Sławomir Wilczyński
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • hydrogels
  • drug release
  • tissue engineering
  • polymer networks

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

17 pages, 7930 KiB  
Article
Evaluation of a Peptide Hydrogel as a Chondro-Instructive Three-Dimensional Microenvironment
by Rodrigo Nogoceke, Raphaella Josino, Anny Waloski Robert and Marco Augusto Stimamiglio
Polymers 2023, 15(24), 4630; https://doi.org/10.3390/polym15244630 - 06 Dec 2023
Viewed by 792
Abstract
Articular cartilage injuries are inherently irreversible, even with the advancement in current therapeutic options. Alternative approaches, such as the use of mesenchymal stem/stromal cells (MSCs) and tissue engineering techniques, have gained prominence. MSCs represent an ideal source of cells due to their low [...] Read more.
Articular cartilage injuries are inherently irreversible, even with the advancement in current therapeutic options. Alternative approaches, such as the use of mesenchymal stem/stromal cells (MSCs) and tissue engineering techniques, have gained prominence. MSCs represent an ideal source of cells due to their low immunogenicity, paracrine activity, and ability to differentiate. Among biomaterials, self-assembling peptide hydrogels (SAPH) are interesting given their characteristics such as good biocompatibility and tunable properties. Herein we associate human adipose-derived stem cells (hASCs) with a commercial SAPH, Puramatrix™, to evaluate how this three-dimensional microenvironment affects cell behavior and its ability to undergo chondrogenic differentiation. We demonstrate that the Puramatrix™ hydrogel comprises a highly porous matrix permissible for hASC adhesion and in vitro expansion. The morphology and cell growth dynamics of hASCs were affected when cultured on the hydrogel but had minimal alteration in their immunophenotype. Interestingly, hASCs spontaneously formed cell aggregates throughout culturing. Analysis of glycosaminoglycan production and gene expression revealed a noteworthy and donor-dependent trend suggesting that Puramatrix™ hydrogel may have a natural capacity to support the chondrogenic differentiation of hASCs. Altogether, the results provide a more comprehensive understanding of the potential applications and limitations of the Puramatrix™ hydrogel in developing functional cartilage tissue constructs. Full article
(This article belongs to the Special Issue Hydrogel Materials for Drug Delivery and Tissue Engineering)
►▼ Show Figures

Figure 1

16 pages, 2906 KiB  
Article
Hydrogel Formulations for Topical Insulin Application: Preparation, Characterization and In Vitro Permeation across the Strat-M® Membrane
by Aneta Ostróżka-Cieślik, Sławomir Wilczyński and Barbara Dolińska
Polymers 2023, 15(17), 3639; https://doi.org/10.3390/polym15173639 - 04 Sep 2023
Cited by 3 | Viewed by 1269
Abstract
Insulin has shown efficacy in the treatment of hard-to-heal wounds, which is mainly due to its role in regulating oxidative stress and inflammatory reactions. The aim of this study was to develop an insulin–hydrogel carrier based on Sepineo™ P 600 and Sepineo™ PHD [...] Read more.
Insulin has shown efficacy in the treatment of hard-to-heal wounds, which is mainly due to its role in regulating oxidative stress and inflammatory reactions. The aim of this study was to develop an insulin–hydrogel carrier based on Sepineo™ P 600 and Sepineo™ PHD 100 for application to lesional skin. Preformulation studies of the developed formulations were performed in terms of analysis of the pharmaceutical availability of insulin from the hydrogels through the Strat-M® membrane, and rheological and texture measurements. Insulin is released in a prolonged manner; after a time of 6.5 h, 4.01 IU/cm2 (53.36%) and 3.69 IU/cm2 (47.4%) of the hormone were released from the hydrogel based on Sepineo™ P 600 and Sepineo™ PHD 100, respectively. Rheological analysis showed that the hydrogels tested belong to non-Newtonian, shear-thinning systems with yield stress. The insulin–hydrogel based on Sepineo™ P 600 and Sepineo™ PHD 100 shows optimal application properties. The results obtained provide a basis for further preclinical and clinical studies. Full article
(This article belongs to the Special Issue Hydrogel Materials for Drug Delivery and Tissue Engineering)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

22 pages, 1286 KiB  
Review
Application of the Quality by Design Concept (QbD) in the Development of Hydrogel-Based Drug Delivery Systems
by S. Farid Mohseni-Motlagh, Roshanak Dolatabadi, Majid Baniassadi and Mostafa Baghani
Polymers 2023, 15(22), 4407; https://doi.org/10.3390/polym15224407 - 14 Nov 2023
Viewed by 2359
Abstract
Hydrogel-based drug delivery systems are of interest to researchers for many reasons, such as biocompatibility, high diversity, and the possibility of administration from different routes. Despite these advantages, there are challenges, such as controlling the drug release rate and their mechanical properties during [...] Read more.
Hydrogel-based drug delivery systems are of interest to researchers for many reasons, such as biocompatibility, high diversity, and the possibility of administration from different routes. Despite these advantages, there are challenges, such as controlling the drug release rate and their mechanical properties during the manufacturing of these systems. For this reason, there is a need for the production and development of such drug delivery systems with a scientific strategy. For this reason, the quality by design (QbD) approach is used for the development of drug delivery systems. This approach, by identifying the most effective factors in the manufacturing of pharmaceutical products and controlling them, results in a product with the desired quality with the least number of errors. In this review article, an attempt is made to discuss the application and method of applying this approach in the development of hydrogel-based drug delivery systems. So that for the development and production of these systems, according to the type of drug delivery system, what target characteristics should be considered (QTPP) and what factors, such as material properties (CMA) or process parameters (CPP), should be taken into account to reach the critical quality attributes of the product (CQA). Full article
(This article belongs to the Special Issue Hydrogel Materials for Drug Delivery and Tissue Engineering)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop