Phytochemical Analysis and Metabolic Profiling in Plants

Dear Colleagues,

Phytochemical analysis and metabolic profiling are essential in plant science. These techniques analyze the chemical composition of plants and identify secondary metabolites such as flavonoids, alkaloids, terpenoids, and phenolic compounds. Advances in analytical technologies have made it possible to use UHPLC-HRMS for phytochemical analysis and metabolic profiling, providing improved separation and detection of a wider range of compounds.

This upcoming issue of the scientific, peer-reviewed, open access journal “Plants”, titled “Phytochemical Analysis and Metabolic Profiling in Plants”, published by MDPI, will focus on the use of modern techniques for metabolic profiling of plant metabolites, as UHPLC-HRMS and modern data analysis methods. The issue will provide a platform for researchers to share their findings and insights in plant science. Articles covering a range of topics, such as the discovery of new metabolites and the development of new analytical methods, are welcome.

We also encourage the use of data analysis techniques, for processing and analyzing mass spectral data. Clustering techniques, such as hierarchical clustering and k-means clustering, and multivariate statistical techniques, such as PCA and PLS-DA, can also enhance the analysis of large and complex datasets.

This issue offers a unique opportunity for researchers to share their latest findings and advance the field of phytochemical analysis and metabolic profiling in plants.

Dr. Yulian Voynikov
Dr. Dimitrina Zheleva-Dimitrova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• phytochemical analysis
• UHPLC-HRMS
• clustering
• data analysis
• secondary metabolites

Title: Elucidation of phloroglucinols from Helichrysum italicum by MS2 fragmentation analysis and clustering techniques
Authors: Yulian Voynikov
Affiliation: Chemistry, Faculty of Pharmacy, Medical Unviersity, Sofia 1000, Bulgaria
Abstract: Helichrysum italicum is a rich source of homo- and hetero-dimerc pyrone and phloroglucinol derivatives. Hetero-dimeric pyrones, consisting of a pyrone ring attached to a phlorogluconil derivative, may be of different types and could be classified as phloroglucinol alpha-pyrones, chromanonepyrones, chromenopyrones, and helispiroketals. Yet, despite the big chemical variety, the information in the literature regarding their MS2 characterization remains scarce, and limited to the most well characterized derivative – arzanol. Arzanol is found in many Helichrysum species and reported to possess antibacterial, anti-inflamatory, antioxidant, and anti-HIV-1 activities. In this article, we explore the elucidation of homo- and hetero-dimeric pyrone phloroglucinol derivatives in hydromethanolic extracts of Helichrysum italicum by analysing the MS2 fragmentation behavior along with employing data analysis and clustering techniques using the R programming language.