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Molecules
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LC-MS Approach in Specialized Natural Products Research
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LC-MS Approach in Specialized Natural Products Research

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 4194

Special Issue Editors

Dr. Dimitrina Zheleva-Dimitrova

E-Mail Website
Guest Editor
Pharmacognosy, Faculty of Pharmacy, Medical Unviersity, Sofia 1000, Bulgaria
Interests: phytochemical analysis; LC-MS; plant metabolomics; pharmacognosy
Special Issues, Collections and Topics in MDPI journals
Dr. Reneta Gevrenova

E-Mail Website
Guest Editor
Department of Pharmacognosy, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav Str, Sofia, Bulgaria
Interests: pharmaacognosy; phytochemistry; natural products; saponins; phenolic compounds; HPLC and LC-MS strategies in specialized natural products elucidation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the past few years, hyphenated techniques as high-performance liquid chromatography coupled to mass high resolution mass spectrometry (HPLC-HRMS) has been used as a powerful tool for the dereplication of known specialized natural products in phytochemistry. Moreover, it has the potential to yield information on the molecular weight as well as on the structure of new natural compounds. LC/HRMS analysis of crude plant extracts allows the localization and targeted isolation of new types of constituents with potential activities. In addition, molecular networking has revealed an approach in dereplication strategies that organizes MS/MS data based on chemical similarity. This Special Issue aims to provide an opportunity for the dissemination of the new approaches and techniques on integrated LC/HRMS strategies for structural elucidation of known and new specialized natural products. As this Special Issue belongs to a section of a chemical journal, all presented work in it must be clearly related to chemical knowledge, i.e., work on extracts or herbal preparations without reliable characterization of chemical constituents will not be considered.

Assoc. Prof. Dr. Dimitrina Zheleva-Dimitrova
Assoc. Prof. Dr. Reneta Gevrenova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • LC-MS in phytochemistry
  • Dereplication of specialized natural products
  • LC-MS-based strategy
  • Structural elucidation
  • Mass spectrometry-based molecular network

Published Papers (1 paper)

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Research

21 pages, 3614 KiB  
Article
Chemophenetic Significance of Anomalocalyx uleanus Metabolites Are Revealed by Dereplication Using Molecular Networking Tools
by José Assis Gomes de Brito, Luciano da Silva Pinto, Cintia Folly Chaves, Antônio Jorge Ribeiro da Silva, Maria Fátima das Graças Fernandes da Silva and Fernando Cotinguiba
Molecules 2021, 26(4), 925; https://doi.org/10.3390/molecules26040925 - 9 Feb 2021
Cited by 5 | Viewed by 2888
Abstract
Anomalocalyx uleanus (Pax & K. Hoffm.) Ducke (Euphorbiaceae) is a singular species in the genus and is restricted and exclusive to the Brazilian Amazon. A phytochemical study of A. uleanus leaves was performed, yielding the isolation of five major compounds: catechin/epicatechin, afzelin, quercetin [...] Read more.
Anomalocalyx uleanus (Pax & K. Hoffm.) Ducke (Euphorbiaceae) is a singular species in the genus and is restricted and exclusive to the Brazilian Amazon. A phytochemical study of A. uleanus leaves was performed, yielding the isolation of five major compounds: catechin/epicatechin, afzelin, quercetin 3-O-α-L-rhamnopyranoside, and astilbin. The phytochemical compositions of the methanolic extracts of leaves, roots, bark, and stem bark were determined using a dereplication approach. Forty-six compounds were annotated from the liquid chromatography-mass spectrometry (LC-MS/MS) data, while four lipids were identified using gas chromatography-mass spectrometry (GC-MS). In total, fifty compounds were detected, and they belonged to the primary metabolism and several classes of natural products such as flavonoids, flavonoids O-glycosides, flavonoids C-glycosides, biflavonoids, procyanidin, triterpene, triterpenes esterified with phenylpropanoids, phenylpropanoid derivatives, flavonolignans, coumarins, quinic acid derivatives, and benzoic acid derivatives. This is the first report on the phytochemical data of the genus Anomalocalyx, and the results of this study will contribute to the chemosystematic knowledge of the Euphorbiaceae family and justify the need for investigation of the pharmacological potential of the species A. uleanus. Full article
(This article belongs to the Special Issue LC-MS Approach in Specialized Natural Products Research)
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