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Photonics
Special Issues
OCT Technology Advances and Their Applications in Disease Studies
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OCT Technology Advances and Their Applications in Disease Studies

A special issue of Photonics (ISSN 2304-6732). This special issue belongs to the section "Biophotonics and Biomedical Optics".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 1107

Special Issue Editors

Dr. Jun Zhu

E-Mail Website
Guest Editor
Postdoc, Department of Molecular and Cellular Biology, University of California Berkeley, 1951 Oxford St., California, CA 94720, USA
Interests: optical coherence tomography; scanning laser ophthalmoscopy; optical microscopy; bioimaging; biophotonics; mouse brain imaging; in vivo imaging
Dr. Conrad Merkle

E-Mail Website
Guest Editor
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20, 4L, 1090 Vienna, Austria
Interests: hemodynamics; neuroimaging; ophthalmology; tomography; optical coherence

Special Issue Information

Dear Colleagues,

Optical Coherence Tomography (OCT) and its associated technologies, such as OCT angiography, Doppler OCT, polarization-sensitive OCT, OCT elastography have been widely applied in ophthalmology, gastroenterology, cancer biology, neuroscience and many other fields. Current efforts in the field are advancing OCT technologies, leading to a higher resolution, faster scanning speed, larger scanning field-of-view, and novel contrast for imaging. With these technical innovations, relevant preclinical and clinical disease studies are being further developed.

This Special Issue aims to present original research studies on advances in OCT-relevant technologies, and their applications in disease studies. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Optical coherence tomography/microscopy;
  • OCT aniography;
  • Low coherence interferometery;
  • Image processing;
  • Polarization sensitive OCT;
  • Spectroscopic OCT;
  • Biophotonics;
  • Retina imaging;
  • Brain imaging;
  • Disease model;
  • Preclinical and clinical imaging.

We look forward to receiving your contributions.

Dr. Jun Zhu
Dr. Conrad Merkle
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Photonics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

14 pages, 6277 KiB  
Article
Effects of Excitation Angle on Air-Puff-Stimulated Surface Acoustic Wave-Based Optical Coherence Elastography (SAW-OCE)
by Zhengshuyi Feng, Yilong Zhang, Weiyi Jiang, Weichen Wang, Chunhui Li and Zhihong Huang
Photonics 2024, 11(3), 254; https://doi.org/10.3390/photonics11030254 - 12 Mar 2024
Viewed by 738
Abstract
Increased stiffness of tissues has been recognised as a diagnostic feature of pathologies. Tissue stiffness characterisation usually involves the detection of tissue response from mechanical stimulation. Air-puff optical coherence elastography (OCE) can generate impulse surface acoustic waves (SAWs) on tissue surface without contact [...] Read more.
Increased stiffness of tissues has been recognised as a diagnostic feature of pathologies. Tissue stiffness characterisation usually involves the detection of tissue response from mechanical stimulation. Air-puff optical coherence elastography (OCE) can generate impulse surface acoustic waves (SAWs) on tissue surface without contact and evaluate the mechanical properties of tissue. This study endeavours to explore the optimal excitation angle for air-puff OCE, a parameter that lacks standardisation at present, by investigating the relationship between the frequency bandwidth and peak-to-peak signal-to-noise ratio (SNR) of SAWs for different excitation angles (relative to the normal surface) of air-puff on the sample, from 5° to 85°, with an interval of 5° applied on the phantom. Due to the unevenness of human hands, 20°, 45° and 70° angles were employed for human skin (10 healthy adults). The results show that a smaller excitation angle could produce higher wave frequency bandwidth; a 5° angle generated an SAW with 1747 Hz frequency bandwidth, while an 85° angle produced an SAW with 1205 Hz. Significant differences were not shown in peak-to-peak SNR comparison between 5° and 65° on the phantom, but between 65° and 85° at the excitation position, a reduction of 48.6% was observed. Furthermore, the group velocity of the SAWs was used to evaluate the bulk Young’s modulus of the human tissue. The outcomes could provide essential guidance for air-puff-based elastography studies in clinical applications and future tissue research. Full article
(This article belongs to the Special Issue OCT Technology Advances and Their Applications in Disease Studies)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Optical Coherence Tomography and Clinicopathological Correlation for Understanding the Pathogenic, Clinical, and Prognostic Implications in Age-Related Macular Degeneration
Authors: Solmaz Abdolrahimzadeh; Serena Fragiotta
Affiliation: Neuroscience, Mental Health & Sensory Organs (NESMOS) Department Faculty of Medicine and Psychology University of Rome Sapienza Azienda Ospedaliera Universitaria Sant'Andrea Via di Grottarossa 1035 - 00189 Roma
Abstract: Optical Coherence Tomography (OCT) has emerged as a pivotal imaging modality in elucidating the pathogenic, clinical, and prognostic implications of age-related macular degeneration (AMD). This review examines the utility of OCT in providing high-resolution, cross-sectional imaging of retinal structures comparable to an in vivo histopathology. Recent histopathological correlations with OCT have enabled precise characterization of AMD extracellular lesions, improving the interpretation of several OCT signatures. By correlating OCT findings with clinicopathological features, a deeper understanding of the underlying pathophysiology of AMD is achieved, facilitating early detection, risk stratification, and therapeutic decision-making. Furthermore, OCT-derived biomarkers offer valuable insights into disease severity, response to treatment, and prognostic outcomes, thereby enhancing patient care and optimizing visual outcomes.

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