Nanolipid-Based Pharmaceutical Dosages Releasing Drugs for Pain Management
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: closed (30 January 2023) | Viewed by 3399
Special Issue Editors
Interests: drug delivery; lipid nanoparticles; nanocarriers; local anesthetics; anti-inflammatory
Special Issues, Collections and Topics in MDPI journals
Interests: drug delivery; nanomaterials characterization; natural excipients; nanocolloids; hybrid formulations
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Analgesia therapy in medical and veterinary routine is employed to minimize and/or prevent painful symptoms of patients. However, such molecules cause important systemic effects on gastrointestinal and cardiovascular systems. Therefore, drugs for pain management must be administered with parsimony, decreasing their therapeutic efficacy. There is still a lack of pharmaceutical dosage forms that can improve the analgesic effect with success while reducing drug toxicity. The development of lipid-based drug delivery systems (LDDS) is a versatile approach aiming long-term analgesia with immediate onset, decreasing toxicity. LDDS, such as liposomes, nanoemulsions, nanostructured lipid carriers, solid lipid nanoparticles, lipid nanocapsules, and lipid-based hybrid formulations, can act as promising matrices to provide novel LDDS for pain management therapies. Nanotechnological innovations and therapies, as well as challenges to be overcome—mainly related to scaling up, economic viability, and preclinical and clinical efficacy assays—should also be discussed.
Prof. Dr. Eneida de Paula
Dr. Lígia N.M. Ribeiro
Guest Editors
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Keywords
- anesthetic
- anti-inflammatory
- opioid
- analgesic
- drug delivery
- lipid nanoparticles
- liposomes
- lipid nanocapsules
- nanoemulsions
- lipid–polymer formulations
- topical forms
- oral forms
- injectable forms
- new candidate drugs
- in vitro characterization methods
- in vivo antinoceptive assays
