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Pharmaceutics
Special Issues
Mucoadhesive Nanosystems for Controlled Drug Release
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Mucoadhesive Nanosystems for Controlled Drug Release

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (10 March 2022) | Viewed by 4650

Special Issue Editor

Prof. Dr. Marcos Luciano Bruschi

E-Mail Website
Guest Editor
Department of Pharmacy, State University of Maringa, Maringa, Brazil
Interests: drug delivery systems; buccal drug administration; smart materials; biopharmaceutics; nanotechnology; biopolymers; biocompatible materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Mucoadhesive drug delivery is a method of controlled drug release which allows for intimate contact between the polymer/system and a target tissue, and increase the residence time of drugs at the site of absorption/action. It provides an attractive strategy to overcome the hurdles of conventional drug delivery systems, and provides great opportunities for the delivery of a variety of compounds via different routes of administration via ocular, nasal, vaginal, rectal and buccal. In addition, mucoadhesion also makes it possible to obtain prolonged, local or systemic drug action.

This Special Issue highlights recent advances in mucoadhesive nanosystems for controlled drug release, including development of mucoadhesive formulations and description of mucoadhesive properties of mucoadhesive materials. We invite articles on all aspects of research in this field, which may help to accelerate scientific knowledge and reach clinical applications.

Prof. Marcos Luciano Bruschi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioadhesion
  • mucoadhesion
  • nanotechnology
  • mucosal drug delivery
  • controlled drug delivery
  • pharmaceutical systems

Published Papers (2 papers)

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Research

18 pages, 2825 KiB  
Article
Mangiferin-Loaded Smart Gels for HSV-1 Treatment
by Mariaconcetta Sicurella, Maddalena Sguizzato, Rita Cortesi, Nicolas Huang, Fanny Simelière, Leda Montesi, Peggy Marconi and Elisabetta Esposito
Pharmaceutics 2021, 13(9), 1323; https://doi.org/10.3390/pharmaceutics13091323 - 24 Aug 2021
Cited by 7 | Viewed by 2276
Abstract
Infections due to HSV-1 affect many people all over the world. To counteract this pathology, usually characterized by perioral sores or by less frequent serious symptoms including keratitis, synthetic antiviral drugs are employed, such as acyclovir, often resulting in resistant viral strains under [...] Read more.
Infections due to HSV-1 affect many people all over the world. To counteract this pathology, usually characterized by perioral sores or by less frequent serious symptoms including keratitis, synthetic antiviral drugs are employed, such as acyclovir, often resulting in resistant viral strains under long-term use. Many plant-derived compounds, such as mangiferin and quercetin, have demonstrated antiviral potentials. In this study, smart semisolid forms based on phosphatidylcholine and Pluronic were investigated as delivery systems to administer mangiferin on skin and mucosae affected by HSV-1 infection. Particularly, lecithin organogels, Pluronic gel, and Pluronic lecithin organogels were formulated and characterized. After the selection of gel compositions, physical aspects, such as rheological behavior, spreadability, leakage, and adhesion were evaluated, suggesting a scarce suitability of the lecithin organogel for topical administration. Mangiferin was efficiently included in all type of gels. An in vitro study based on the Franz cell enabled us to find evidence of the gel capability to control drug diffusion, especially in the case of Pluronic organogel, while an in vivo study conducted on human volunteers demonstrated the safeness of all of the gels after cutaneous administration. Furthermore, a plaque reduction assay demonstrated the virucidal effect of mangiferin loaded in a Pluronic gel and a Pluronic lecithin organogel against the HSV-1 KOS strain. Full article
(This article belongs to the Special Issue Mucoadhesive Nanosystems for Controlled Drug Release)
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17 pages, 4489 KiB  
Article
Design of Mucoadhesive Strips for Buccal Fast Release of Tramadol
by Nayla Francine Garcia Pastório, Camila Felix Vecchi, Rafaela Said dos Santos and Marcos Luciano Bruschi
Pharmaceutics 2021, 13(8), 1187; https://doi.org/10.3390/pharmaceutics13081187 - 31 Jul 2021
Cited by 3 | Viewed by 1791
Abstract
Tramadol hydrochloride is a synthetic analogue of codeine and shows activity on the central nervous system as an opioid agonist and inhibitor of serotonin and norepinephrine reuptake. It has been used for controlling moderate to severe pain. Mucoadhesive fast-dissolving films can present greater [...] Read more.
Tramadol hydrochloride is a synthetic analogue of codeine and shows activity on the central nervous system as an opioid agonist and inhibitor of serotonin and norepinephrine reuptake. It has been used for controlling moderate to severe pain. Mucoadhesive fast-dissolving films can present greater drug availability and patient acceptance when compared to the systems of peroral administration. The films were prepared using the solvent casting method with ethylcellulose, polyvinylpyrrolidone and poly(vinyl alcohol). The effect of each polymer concentration was investigated using a 2³ factorial design with repetition at the central point. The formulations were subjected to physicochemical, mechanical, ex vivo mucoadhesive and in vitro drug release profile analysis. These properties were dependent on the polymeric composition (independent factors) of each system. The optimized formulations showed good macroscopic characteristics, improved resistance to bending, rigidity, rapid swelling up to 60 s, improved mechanical and mucoadhesive characteristics, and also fast dissolving and tramadol release. The optimized formulations constitute platforms and strategies to improve the therapy of tramadol with regard to availability at the site of application, considering the necessity of rapid pain relief, and show potential for in vivo evaluation. Full article
(This article belongs to the Special Issue Mucoadhesive Nanosystems for Controlled Drug Release)
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