Special Issue "Pharmaceutical Formulations and Bioavailability Enhancement Techniques for Transmucosal Drug Delivery"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: 31 January 2024 | Viewed by 526

Special Issue Editors

Midwest Campus, Federal University of Sao Joao del-Rei, São João del Rei, Brazil
Interests: drug delivery systems; buccal drug administration; smart materials; biopharmaceutics; iontophoresis; nanotechnology; biopolymers; biocompatible materials; systematic reviews
Department of Pharmacy, State University of Maringa, Maringa, Brazil
Interests: drug delivery systems; buccal drug administration; smart materials; biopharmaceutics; nanotechnology; biopolymers; biocompatible materials
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Special Issue Information

Dear Colleagues,

Efforts to overcome the limitations imposed by the various physiological barriers of the human body in order to reach enhanced treatment outcomes have been challenging scientists worldwide over the last decades.

In this Special Issue of Pharmaceutics, authors from both academic and industrial backgrounds are invited to submit original articles for publication. These should report evidence of preclinical (in silico, in vitro or in vivo) and clinical trials, addressing the promising applications of drug delivery systems and permeation enhancement strategies through the buccal, nasal, ocular, rectal, and vaginal mucosa. Systematic reviews and meta-analyses on related subjects in this field will also be considered for publication.

Prof. Dr. Renê Oliveira Do Couto
Prof. Dr. Marcos Luciano Bruschi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery systems
  • buccal drug administration
  • smart materials
  • biopharmaceutics
  • iontophoresis
  • nanotechnology
  • biopolymers
  • biocompatible Materials
  • dendrimers
  • liposomes
  • phonophoresis
  • oral mucosal absorption
  • mucosal administrations
  • ophthalmic administration
  • nasal administration
  • rectal administration
  • mucoadhesive polymers
  • vaginal administration
  • preclinical drug evaluation

Published Papers (1 paper)

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Research

Article
Dynamic Ex Vivo Porcine Eye Model to Measure Ophthalmic Drug Penetration under Simulated Lacrimal Flow
Pharmaceutics 2023, 15(9), 2325; https://doi.org/10.3390/pharmaceutics15092325 - 15 Sep 2023
Viewed by 285
Abstract
Animal models are still used in the research and development of ophthalmic drug products, mainly due to the difficulty in simulating natural physiological conditions with in vitro models, as there is a lack of dynamic protection mechanisms. Therefore, developing alternative ophthalmic models that [...] Read more.
Animal models are still used in the research and development of ophthalmic drug products, mainly due to the difficulty in simulating natural physiological conditions with in vitro models, as there is a lack of dynamic protection mechanisms. Therefore, developing alternative ophthalmic models that evaluate drug penetration in the cornea while applying dynamic protection barriers is a contemporary challenge. This study aimed to develop a dynamic ex vivo model using porcine eyes with a simulated lacrimal flow to evaluate the performance of pharmaceutical drug products. A glass donor cell to support a simulated tear flow was designed, optimized, and custom-made. The system was challenged with different formulations (with fluconazole) including excipients with different viscosities (poloxamer 407) and mucoadhesive properties (chitosan). The results were compared to those obtained from a conventional excised cornea model mounted in Franz-type diffusion cells. The dynamic model could differentiate formulations, while the static model did not, overestimating ex vivo drug penetrated amounts. Hence, the dynamic model with simulated tear flow showed to be a simple and promising new alternative method for the drug penetration of ophthalmic formulations that ultimately can reduce the number of animals used in research. Full article
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