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Pharmaceutics
Special Issues
Trends in Drug Delivery for Wounds Treatment
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Trends in Drug Delivery for Wounds Treatment

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 18718

Special Issue Editors

Dr. Daniele Ribeiro de Araujo

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Guest Editor
Drug and Bioactives Delivery Systems Research Group (SISLIBIO), Human and Natural Sciences Center, Federal University of ABC, Santo André 09210-580, São Paulo, Brazil
Interests: nanobiotechnology; nanomedicine; stimuli-responsive polymeric drug-delivery systems (micelles, hydrogels, organogels)
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. César Viseras

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Guest Editor
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain
Interests: medicinal products; medical devices; pharmaceutical technology; drug delivery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Fernanda Nervo Raffin

E-Mail Website
Guest Editor
Laboratory of Drug Development, Department of Pharmacy, School of Pharmacy, Federal University of Rio Grande do Norte, Av. Gal. Gustavo Cordeiro de Farias, Petrópolis 59010-180, Natal, Brazil
Interests: drug delivery; neglected diseases; solid dispersions; lipid nanocarriers; microparticulated systems
Dr. Raquel De M. Barbosa

E-Mail Website
Guest Editor
Laboratory of Drug Development, Department of Pharmacy, School of Pharmacy, Federal University of Rio Grande do Norte, Av. Gal. Gustavo Cordeiro de Farias, Petrópolis 59010-180, Natal, Brazil
Interests: drug delivery; nanomedicine; wound healing; polymer-based micelles; liposomes; design and control; quality control; design and production of hybrid nanocomposite and nano-systems (lipid and polymeric) for pharmaceutical and cosmetic applications.
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

One of the enormous challenges in clinical medicine is the rapid and efficient treatment of complex chronic wounds. The subject is much discussed and considered a serious world health problem. Chronic wounds such as diabetic foot, venous leg ulcers, and pressure ulcers have common features such as prolonged or excessive inflammation, persistent infections, the formation of drug-resistant microbial biofilms, and the inability of epidermal cells to respond to repair stimuli. Innovative drug-delivery systems based on nanotechnology for wound treatment have been used because of their distinct advantages: they are versatile due to their wide range of mechanical, chemical, and physical properties and availability at reasonable costs. In this way, this Special Issue of the Pharmaceutics journal will be open to discussing advanced knowledge in technological development in therapeutic dressings. The work should have a strong evidence base to support the promotion and exploration of the research results and prospects for meeting an unmet need for both clinicians and patients (beneficiaries).

Dr. Daniele Ribeiro de Araujo
Prof. Dr. César Viseras
Prof. Dr. Fernanda Nervo Raffin
Dr. Raquel De M. Barbosa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wounds
  • drug delivery
  • lipid-based nanoparticle
  • lipid–polymer formulations
  • hybrid systems
  • polymeric nanoparticles
  • in vitro characterization methods
  • in vivo assays

Published Papers (5 papers)

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Research

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13 pages, 2926 KiB  
Article
Topical Chitosan-Based Thermo-Responsive Scaffold Provides Dexketoprofen Trometamol Controlled Release for 24 h Use
by Luis Castillo-Henríquez, Pablo Sanabria-Espinoza, Brayan Murillo-Castillo, Gabriela Montes de Oca-Vásquez, Diego Batista-Menezes, Briner Calvo-Guzmán, Nils Ramírez-Arguedas and José Vega-Baudrit
Pharmaceutics 2021, 13(12), 2100; https://doi.org/10.3390/pharmaceutics13122100 - 06 Dec 2021
Cited by 15 | Viewed by 3575
Abstract
Chronic and non-healing wounds demand personalized and more effective therapies for treating complications and improving patient compliance. Concerning that, this work aims to develop a suitable chitosan-based thermo-responsive scaffold to provide 24 h controlled release of Dexketoprofen trometamol (DKT). Three formulation prototypes were [...] Read more.
Chronic and non-healing wounds demand personalized and more effective therapies for treating complications and improving patient compliance. Concerning that, this work aims to develop a suitable chitosan-based thermo-responsive scaffold to provide 24 h controlled release of Dexketoprofen trometamol (DKT). Three formulation prototypes were developed using chitosan (F1), 2:1 chitosan: PVA (F2), and 1:1 chitosan:gelatin (F3). Compatibility tests were done by DSC, TG, and FT-IR. SEM was employed to examine the morphology of the surface and inner layers from the scaffolds. In vitro release studies were performed at 32 °C and 38 °C, and the profiles were later adjusted to different kinetic models for the best formulation. F3 showed the most controlled release of DKT at 32 °C for 24 h (77.75 ± 2.72%) and reduced the burst release in the initial 6 h (40.18 ± 1.00%). The formulation exhibited a lower critical solution temperature (LCST) at 34.96 °C, and due to this phase transition, an increased release was observed at 38 °C (88.52 ± 2.07% at 12 h). The release profile for this formulation fits with Hixson–Crowell and Korsmeyer–Peppas kinetic models at both temperatures. Therefore, the developed scaffold for DKT delivery performs adequate controlled release, thereby; it can potentially overcome adherence issues and complications in wound healing applications. Full article
(This article belongs to the Special Issue Trends in Drug Delivery for Wounds Treatment)
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22 pages, 2486 KiB  
Article
Protease-Triggered Release of Stabilized CXCL12 from Coated Scaffolds in an Ex Vivo Wound Model
by Sabrina Spiller, Tom Wippold, Kathrin Bellmann-Sickert, Sandra Franz, Anja Saalbach, Ulf Anderegg and Annette G. Beck-Sickinger
Pharmaceutics 2021, 13(10), 1597; https://doi.org/10.3390/pharmaceutics13101597 - 01 Oct 2021
Cited by 3 | Viewed by 2408
Abstract
Biomaterials are designed to improve impaired healing of injured tissue. To accomplish better cell integration, we suggest to coat biomaterial surfaces with bio-functional proteins. Here, a mussel-derived surface-binding peptide is used and coupled to CXCL12 (stromal cell-derived factor 1α), a chemokine that activates [...] Read more.
Biomaterials are designed to improve impaired healing of injured tissue. To accomplish better cell integration, we suggest to coat biomaterial surfaces with bio-functional proteins. Here, a mussel-derived surface-binding peptide is used and coupled to CXCL12 (stromal cell-derived factor 1α), a chemokine that activates CXCR4 and consequently recruits tissue-specific stem and progenitor cells. CXCL12 variants with either non-releasable or protease-mediated-release properties were designed and compared. Whereas CXCL12 was stabilized at the N-terminus for protease resistance, a C-terminal linker was designed that allowed for specific cleavage-mediated release by matrix metalloproteinase 9 and 2, since both enzymes are frequently found in wound fluid. These surface adhesive CXCL12 derivatives were produced by expressed protein ligation. Functionality of the modified chemokines was assessed by inositol phosphate accumulation and cell migration assays. Increased migration of keratinocytes and primary mesenchymal stem cells was demonstrated. Immobilization and release were studied for bioresorbable PCL-co-LC scaffolds, and accelerated wound closure was demonstrated in an ex vivo wound healing assay on porcine skin grafts. After 24 h, a significantly improved CXCL12-specific growth stimulation of the epithelial tips was already observed. The presented data display a successful application of protein-coated biomaterials for skin regeneration. Full article
(This article belongs to the Special Issue Trends in Drug Delivery for Wounds Treatment)
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33 pages, 5756 KiB  
Article
Glibenclamide Nanocrystal-Loaded Bioactive Polymeric Scaffolds for Skin Regeneration: In Vitro Characterization and Preclinical Evaluation
by Julie R. Youssef, Nabila A. Boraie, Heba F. Ibrahim, Fatma A. Ismail and Riham M. El-Moslemany
Pharmaceutics 2021, 13(9), 1469; https://doi.org/10.3390/pharmaceutics13091469 - 14 Sep 2021
Cited by 6 | Viewed by 2986 | Correction
Abstract
Skin restoration following full-thickness injury poses significant clinical challenges including inflammation and scarring. Medicated scaffolds formulated from natural bioactive polymers present an attractive platform for promoting wound healing. Glibenclamide was formulated in collagen/chitosan composite scaffolds to fulfill this aim. Glibenclamide was forged into [...] Read more.
Skin restoration following full-thickness injury poses significant clinical challenges including inflammation and scarring. Medicated scaffolds formulated from natural bioactive polymers present an attractive platform for promoting wound healing. Glibenclamide was formulated in collagen/chitosan composite scaffolds to fulfill this aim. Glibenclamide was forged into nanocrystals with optimized colloidal properties (particle size of 352.2 nm, and polydispersity index of 0.29) using Kolliphor as a stabilizer to allow loading into the hydrophilic polymeric matrix. Scaffolds were prepared by the freeze drying method using different total polymer contents (3–6%) and collagen/chitosan ratios (0.25–2). A total polymer content of 3% at a collagen/chitosan ratio of 2:1 (SCGL3-2) was selected based on the results of in vitro characterization including the swelling index (1095.21), porosity (94.08%), mechanical strength, rate of degradation and in vitro drug release. SCGL3-2 was shown to be hemocompatible based on the results of protein binding, blood clotting and percentage hemolysis assays. In vitro cell culture studies on HSF cells demonstrated the biocompatibility of nanocrystals and SCGL3-2. In vivo studies on a rat model of a full-thickness wound presented rapid closure with enhanced histological and immunohistochemical parameters, revealing the success of the scaffold in reducing inflammation and promoting wound healing without scar formation. Hence, SCGL3-2 could be considered a potential dermal substitute for skin regeneration. Full article
(This article belongs to the Special Issue Trends in Drug Delivery for Wounds Treatment)
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Review

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23 pages, 2625 KiB  
Review
Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair
by Eliana B. Souto, Cristiana M. P. Yoshida, Gislaine R. Leonardi, Amanda Cano, Elena Sanchez-Lopez, Aleksandra Zielinska, César Viseras, Patricia Severino, Classius F. da Silva and Raquel de M. Barbosa
Pharmaceutics 2021, 13(8), 1199; https://doi.org/10.3390/pharmaceutics13081199 - 04 Aug 2021
Cited by 12 | Viewed by 3541
Abstract
The use of lipids in the composition of polymeric-based films for topical administration of bioactive ingredients is a recent research topic; while few products are commercially available, films containing lipids represent a strategic area for the development of new products. Some lipids are [...] Read more.
The use of lipids in the composition of polymeric-based films for topical administration of bioactive ingredients is a recent research topic; while few products are commercially available, films containing lipids represent a strategic area for the development of new products. Some lipids are usually used in polymeric-based film formulations due to their plasticizing action, with a view to improving the mechanical properties of these films. On the other hand, many lipids have healing, antimicrobial, anti-inflammatory, anti-aging properties, among others, that make them even more interesting for application in the medical-pharmaceutical field. This manuscript discusses the production methods of these films both on a laboratory and at industrial scales, the properties of the developed biopolymers, and their advantages for the development of dermatologic and cosmetic products. Full article
(This article belongs to the Special Issue Trends in Drug Delivery for Wounds Treatment)
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18 pages, 326 KiB  
Review
Electrospun Nanofibers/Nanofibrous Scaffolds Loaded with Silver Nanoparticles as Effective Antibacterial Wound Dressing Materials
by Sibusiso Alven, Buhle Buyana, Zizo Feketshane and Blessing Atim Aderibigbe
Pharmaceutics 2021, 13(7), 964; https://doi.org/10.3390/pharmaceutics13070964 - 26 Jun 2021
Cited by 62 | Viewed by 4983
Abstract
The treatment of wounds is expensive and challenging. Most of the available wound dressings are not effective and suffer from limitations such as poor antimicrobial activity, toxicity, inability to provide suitable moisture to the wound and poor mechanical performance. The use of inappropriate [...] Read more.
The treatment of wounds is expensive and challenging. Most of the available wound dressings are not effective and suffer from limitations such as poor antimicrobial activity, toxicity, inability to provide suitable moisture to the wound and poor mechanical performance. The use of inappropriate wound dressings can result in a delayed wound healing process. Nanosize range scaffolds have triggered great attention because of their attractive properties, which include their capability to deliver bioactive agents, high surface area, improved mechanical properties, mimic the extracellular matrix (ECM), and high porosity. Nanofibrous materials can be further encapsulated/loaded with metal-based nanoparticles to enhance their therapeutic outcomes in wound healing applications. The widely studied metal-based nanoparticles, silver nanoparticles exhibit good properties such as outstanding antibacterial activity, display antioxidant, and anti-inflammatory properties, support cell growth, making it an essential bioactive agent in wound dressings. This review article reports the biological (in vivo and in vitro) and mechanical outcomes of nanofibrous scaffolds loaded with silver nanoparticles on wound healing. Full article
(This article belongs to the Special Issue Trends in Drug Delivery for Wounds Treatment)
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