Oligonucleotide-Based Delivery Systems
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 7207
Special Issue Editors
Interests: drug delivery systems; lipid nanoparticles; liposomes; targeting
Interests: antisense therapeutics; nucleic acid chemistry; ligand-targeted oligonucleotide delivery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent years, delivery studies of oligonucleotides including messenger RNA, small interfering RNA, microRNA, and antisense oligonucleotides have been intensively conducted. Currently, oligonucleotide drug delivery research can be broadly classified into 1) chemical modification and ligand conjugation of oligonucleotides, 2) nano-particulation such as lipid nanoparticles, and 3) the use of external stimuli, with attempts to combine each method. It is also important to properly evaluate and understand the pharmacokinetics and toxicity of the oligonucleotides compositions, and to justify their delivery strategies at the body, tissue, and cellular levels.
In this Special Issue on "Oligonucleotide-Based Delivery Systems," we will focus on the development of new delivery systems of therapeutic oligonucleotides to be able to target various organs, tissues, and cells with a systematic evaluation of the pharmacokinetics and toxicity of the formulations. We would like to discuss the therapeutic possibilities of novel oligonucleotide-based drugs with specialized delivery systems for refractory diseases, and to consider their potential problems to be solved.
Prof. Dr. Shigeru Kawakami
Dr. Tsuyoshi Yamamoto
Guest Editors
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Keywords
- drug delivery systems
- oligonucleotides
- lipid nanoparticles (LNPs)
- ligand conjugation
- pharmacokinetics
- toxicity
