Special Issue "Recent Advances in Drug Delivery and Treatment of Neglected Tropical Diseases"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 603

Special Issue Editors

Institute for Advanced Studies of Ocean, São Paulo State University (UNESP), São Vicente 11350-011, Brazil
Interests: neglected tropical diseases; parasite; bacteria; virus; fungus; oral and local treatment; formulations; dermatological cream; liposome; nanoparticles; immunity
Special Issues, Collections and Topics in MDPI journals
Departament of Pharmaceutics and Food Technology, School of Pharmacy, University Complutense, Avenida Complutense, 28040 Madrid, Spain
Interests: nanomedicines; microparticles; sustained-release formulations; liposomes; nanoparticles; drug targeting; pharmacokinetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Around 1.6 billion people are affected by neglected tropical diseases (NDTs) whose etiologic agents are related to bacteria, viruses, fungi, and parasites. These diseases frequently occur in tropical countries and in general affect vulnerable people living in close contact with such organisms. Control of NTDs has been considered a real challenge because the life cycles of etiologic agents are complex and involve the participation of different reservoirs and there are no effective prophylactic measures in place.

Chemotherapy for NTD is far from ideal, considering that drugs in use induce serious side effects in patients, the therapeutic activity may be variable for some clinical forms, and the emergence of naturally resistant microorganisms.

This Special Issue is open to articles focused on novel formulations to target NTDs through different administration routes such as oral, topical and parenteral with a special focus on micro and nanomedicines including pharmacokinetics and pharmacodynamics studies.

Dr. Luiz Felipe Domingues Passero
Dr. Dolores R. Serrano
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • neglected tropical diseases
  • drug targeting
  • microparticulate formulations
  • novel formulations
  • liposomes
  • nanomedicines

Published Papers (1 paper)

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18 pages, 5758 KiB  
Therapeutic Activity of a Topical Formulation Containing 8-Hydroxyquinoline for Cutaneous Leishmaniasis
Pharmaceutics 2023, 15(11), 2602; https://doi.org/10.3390/pharmaceutics15112602 - 08 Nov 2023
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Cutaneous leishmaniasis exhibits a wide spectrum of clinical manifestations; however, only a limited number of drugs are available and include Glucantime® and amphotericin B, which induce unacceptable side effects in patients, limiting their use. Thus, there is an urgent demand to develop [...] Read more.
Cutaneous leishmaniasis exhibits a wide spectrum of clinical manifestations; however, only a limited number of drugs are available and include Glucantime® and amphotericin B, which induce unacceptable side effects in patients, limiting their use. Thus, there is an urgent demand to develop a treatment for leishmaniasis. Recently, it was demonstrated that 8-hydroxyquinoline (8-HQ) showed significant leishmanicidal effects in vitro and in vivo. Based on that, this work aimed to develop a topical formulation containing 8-HQ and assess its activity in experimental cutaneous leishmaniasis. 8-HQ was formulated using a Beeler base at 1 and 2% and showed an emulsion size with a D50 of 25 and 51.3 µm, respectively, with a shear-thinning rheological behaviour. The creams were able to permeate artificial Strat-M membranes and excised porcine skin without causing any morphological changes in the porcine skin or murine skin tested. In BALB/c mice infected with L. (L.) amazonensis, topical treatment with creams containing 1 or 2% of 8-HQ was found to reduce the parasite burden and lesion size compared to infected controls with comparable efficacy to Glucantime® (50 mg/kg) administered at the site of the cutaneous lesion. In the histological section of the skin from infected controls, a diffuse inflammatory infiltrate with many heavily infected macrophages that were associated with areas of necrosis was observed. On the other hand, animals treated with both creams showed only moderate inflammatory infiltrate, characterised by few infected macrophages, while tissue necrosis was not observed. These histological characteristics in topically treated animals were associated with an increase in the amount of IFN-γ and a reduction in IL-4 levels. The topical use of 8-HQ was active in decreasing tissue parasitism and should therefore be considered an interesting alternative directed to the treatment of leishmaniasis, considering that this type of treatment is non-invasive, painless, and, importantly, does not require hospitalisation, improving patient compliance by allowing the treatment to be conducted. Full article
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