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Pharmaceutics
Special Issues
Pharmaceutics and Drug Delivery in Italy, 2nd Edition
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Pharmaceutics and Drug Delivery in Italy, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1408

Special Issue Editors

Prof. Dr. Paola Mura

E-Mail Website
Guest Editor
Department of Chemistry, University of Florence, via Schiff 6, Sesto Fiorentino, 50019 Florence, Italy
Interests: cyclodextrins complexes; dissolution; nanocarriers as drug delivery systems; drug-in cyclodextrin-in nanocarrier; transmucosal delivery
Special Issues, Collections and Topics in MDPI journals
Dr. Francesca Maestrelli

E-Mail Website
Guest Editor
Department of Chemistry, University of Florence, via Schiff 6, Sesto Fiorentino, 50019 Florence, Italy
Interests: cyclodextrins; drug delivery systems; drug-in-cyclodextrins-in-colloidal systems; microparticulate systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Considering the great success of the previous Special Issue about Pharmaceutics and Drug Delivery in Italy, and the continuous evolution of research in this field, this Special Issue aims to update the status of the art of academic research in Italy in the pharmaceutical technology field, covering all aspects related to drug delivery sciences, spanning from the design, synthesis, production, and characterization at the pre-clinical level up to practical applications and human clinical trials. The contributions of Italian researchers in this field have increased exponentially in recent years. In this respect, this Special Issue wishes to gather the most representative examples of current research in the Italian academic laboratories of pharmaceutical technology. Italian Researchers have been exploring an extensive variety of topics, including different types of conventional and innovative dosage forms, methods to increase drug solubility, dissolution rate, stability, and permeation through cell membranes, nanotechnological approaches for the control of release and drug targeting, nanotechnology-based drugs, gene delivery systems, and new cellular therapies.

We are pleased to invite you to contribute to this Special Issue with original research articles or reviews.

We look forwards to receiving your contributions.

Prof. Dr. Paola Mura
Dr. Francesca Maestrelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmaceutical technology
  • dosage forms
  • drug development and targeting
  • nanotechnology in drug delivery
  • protein, peptide, and gene drug delivery
  • novel drug formulations: 2D and 3D printing applications
  • biomaterials in drug delivery
  • regulatory issues in pharmaceutics and novel drug delivery
  • delivery of herbal medicinal products
  • cell delivery

Published Papers (2 papers)

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Research

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13 pages, 2160 KiB  
Article
Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization
by Iriczalli Cruz-Maya, Carmine Schiavone, Rosalia Ferraro, Nergis Zeynep Renkler, Sergio Caserta and Vincenzo Guarino
Pharmaceutics 2024, 16(2), 193; https://doi.org/10.3390/pharmaceutics16020193 - 29 Jan 2024
Viewed by 887
Abstract
Innovations in drug delivery systems are crucial for enhancing therapeutic efficiency. Our research presents a novel approach based on using electro-fluid dynamic atomization (EFDA) to fabricate core-shell monophasic particles (CSMp) from sodium alginate blends of varying molecular weights. This study explores the morphological [...] Read more.
Innovations in drug delivery systems are crucial for enhancing therapeutic efficiency. Our research presents a novel approach based on using electro-fluid dynamic atomization (EFDA) to fabricate core-shell monophasic particles (CSMp) from sodium alginate blends of varying molecular weights. This study explores the morphological characteristics of these particles in relation to material properties and process conditions, highlighting their potential in drug delivery applications. A key aspect of our work is the development of a mathematical model that simulates the release kinetics of small molecules, specifically sodium diclofenac. By assessing the diffusion properties of different molecules and gel formulations through transport and rheological models, we have created a predictive tool for evaluating the efficiency of these particles in drug delivery. Our findings underscore two critical, independent parameters for optimizing drug release: the external shell thickness and the diffusivity ratios within the dual layers. This allows for precise control over the timing and intensity of the release profile. This study advances our understanding of EFDA in the fabrication of CSMp and offers promising avenues for enhancing drug delivery systems by tailoring release profiles through particle characteristic manipulation. Full article
(This article belongs to the Special Issue Pharmaceutics and Drug Delivery in Italy, 2nd Edition)
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Review

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25 pages, 2031 KiB  
Review
Attempts to Improve Lipophilic Drugs’ Solubility and Bioavailability: A Focus on Fenretinide
by Silvana Alfei and Guendalina Zuccari
Pharmaceutics 2024, 16(5), 579; https://doi.org/10.3390/pharmaceutics16050579 - 24 Apr 2024
Viewed by 272
Abstract
The development of numerous drugs is often arrested at clinical testing stages, due to their unfavorable biopharmaceutical characteristics. It is the case of fenretinide (4-HPR), a second-generation retinoid, that demonstrated promising in vitro cytotoxic activity against several cancer cell lines. Unfortunately, response rates [...] Read more.
The development of numerous drugs is often arrested at clinical testing stages, due to their unfavorable biopharmaceutical characteristics. It is the case of fenretinide (4-HPR), a second-generation retinoid, that demonstrated promising in vitro cytotoxic activity against several cancer cell lines. Unfortunately, response rates in early clinical trials with 4-HPR did not confirm the in vitro findings, mainly due to the low bioavailability of the oral capsular formulation that was initially developed. Capsular 4-HPR provided variable and insufficient drug plasma levels attributable to the high hepatic first-pass effect and poor drug water solubility. To improve 4-HPR bioavailability, several approaches have been put forward and tested in preclinical and early-phase clinical trials, demonstrating generally improved plasma levels and minimal systemic toxicities, but also modest antitumor efficacy. The challenge is thus currently still far from being met. To redirect the diminished interest of pharmaceutical companies toward 4-HPR and promote its further clinical development, this manuscript reviewed the attempts made so far by researchers to enhance 4-HPR bioavailability. A comparison of the available data was performed, and future directions were proposed. Full article
(This article belongs to the Special Issue Pharmaceutics and Drug Delivery in Italy, 2nd Edition)
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