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Pharmaceutics
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Advanced Bio-Hybrid Materials for Drug Delivery Systems - New Trends...
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Advanced Bio-Hybrid Materials for Drug Delivery Systems - New Trends and Perspectives, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1640

Special Issue Editors

Dr. Katarzyna Bialik-Wąs

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Guest Editor
Institute of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska St., 31-155 Cracow, Poland.
Interests: organic chemistry; medicinal chemistry; synthesis; pharmaceuticals; material characterization; polymers; nanomaterials; drug delivery systems; polymeric biomaterials; hydrogels; bio-hybrid hydrogels; advanced polymeric materials; polymeric biomaterials; biopolymers; drug delivery systems; natural and synthetic active substances; nanocarriers
Special Issues, Collections and Topics in MDPI journals
Dr. Katarzyna Malarz

E-Mail Website
Guest Editor
A. Chełkowski Institute of Physics and Silesian Center for Education and Interdisciplinary Research, University of Silesia in Katowice, 75 Pułku Piechoty 1, 41-500 Chorzów, Poland
Interests: anticancer activity; kinase inhibition; signalling cancer pathways; metal chelators; thiosemicarbazones; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Dr. Małgorzata Miastkowska

E-Mail Website
Guest Editor
Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, 24 Warszawska St., 31155 Cracow, Poland
Interests: lipid nanocarriers; hydrogles; wound healing; skin disorders; skin regeneration; drug release kinetics; design of experiments (DOE); molecular dynamics (MD)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Due to pollution of our environment, unhealthy lifestyle, as well as stress, causing a variety of chronic disorders, currently, both, the medical and pharmaceutical markets are developing at an intense rate. People need new solutions. Therefore, it is important to consider what the new trends are, as well as possible novel perspectives. There are so many questions related to this topic. This is why recently, many groups of scientists are focusing on the preparation and advanced functional bio-hybrid materials for biomedical applications and drug delivery systems. We can distinguish different systems based on polymeric, organic, inorganic micro/nanocarriers or their combination with biopolymeric, polymeric or hydrogel matrices, which enables the controlled, sustained or modified release of active substances derived from natural or synthetic origin. In addition to the synthesis, physicochemical and structural properties, it is very important to determine the drug release profile and ensure a safe therapeutic concentration. Moreover, from an application point of view, the cytotoxicity assays are essential. I believe that together we can make more, leading to a significant change in people’s quality of life.

This Special Issue will allow us to share achieved goals and new approaches in designing smart drug delivery systems.

Dr. Katarzyna Bialik-Wąs
Dr. Katarzyna Malarz
Dr. Małgorzata Miastkowska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micro-/nanocarriers
  • advanced materials
  • bio-hybrid hydrogels
  • transdermal systems
  • controlled release
  • drug delivery systems
  • drug carriers
  • cytotoxicity assays
  • biodegradability
  • in vitro and 3D models

Published Papers (1 paper)

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Research

28 pages, 7440 KiB  
Article
Topical Formulations Based on Ursolic Acid-Loaded Nanoemulgel with Potential Application in Psoriasis Treatment
by Małgorzata Miastkowska, Agnieszka Kulawik-Pióro, Elwira Lasoń, Karolina Śliwa, Magdalena Anna Malinowska, Elżbieta Sikora, Tomasz Kantyka, Ewa Bielecka, Anna Maksylewicz, Emilia Klimaszewska, Marta Ogorzałek, Małgorzata Tabaszewska, Łukasz Skoczylas and Krzysztof Nowak
Pharmaceutics 2023, 15(11), 2559; https://doi.org/10.3390/pharmaceutics15112559 - 31 Oct 2023
Cited by 2 | Viewed by 1430
Abstract
Psoriasis is a chronic disorder that causes a rash with itchy, scaly patches. It affects nearly 2–5% of the worldwide population and has a negative effect on patient quality of life. A variety of therapeutic approaches, e.g., glucocorticoid topical therapy, have shown limited [...] Read more.
Psoriasis is a chronic disorder that causes a rash with itchy, scaly patches. It affects nearly 2–5% of the worldwide population and has a negative effect on patient quality of life. A variety of therapeutic approaches, e.g., glucocorticoid topical therapy, have shown limited efficacy with systemic adverse reactions. Therefore, novel therapeutic agents and physicochemical formulations are in constant need and should be obtained and tested in terms of effectiveness and minimization of side effects. For that reason, the aim of our study was to design and obtain various hybrid systems, nanoemulgel–macroemulsion and nanoemulgel–oleogel (bigel), as vehicles for ursolic acid (UA) and to verify their potential as topical formulations used in psoriasis treatment. Obtained topical formulations were characterized by conducting morphological, rheological, texture, and stability analysis. To determine the safety and effectiveness of the prepared ursolic acid carriers, in vitro studies on human keratinocyte cell-like HaCaT cells were performed with cytotoxicity analysis for individual components and each formulation. Moreover, a kinetic study of ursolic acid release from the obtained systems was conducted. All of the studied UA-loaded systems were well tolerated by keratinocyte cells and had suitable pH values and stability over time. The obtained formulations exhibit an apparent viscosity, ensuring the appropriate time of contact with the skin, ease of spreading, soft consistency, and adherence to the skin, which was confirmed by texture tests. The release of ursolic acid from each of the formulations is followed by a slow, controlled release according to the Korsmeyer–Peppas and Higuchi models. The elaborated systems could be considered suitable vehicles to deliver triterpene to psoriatic skin. Full article
(This article belongs to the Special Issue Advanced Bio-Hybrid Materials for Drug Delivery Systems - New Trends and Perspectives, 2nd Edition)
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