Special Issue "Protein Kinase Inhibitors for Targeted Anticancer Therapies, 2nd Edition"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 163

Special Issue Editor

A. Chełkowski Institute of Physics and Silesian Center for Education and Interdisciplinary Research, University of Silesia in Katowice, 75 Pułku Piechoty 1, 41-500 Chorzów, Poland
Interests: anticancer activity; kinase inhibition; signalling cancer pathways; metal chelators; thiosemicarbazones; oxidative stress
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Special Issue Information

Dear Colleagues,

Protein kinase inhibitors are one of the most promising groups of drugs for targeted therapies. According to the latest data, 62 small-molecule protein kinase inhibitors have been approved by the Federal Drug Administration (FDA) (37 in the last 5 years), while at least 150 are currently being investigated in clinical trials. This is primarily due to a better understanding of the complex signaling network formed by kinases and their mutual relationships in signal transduction cascades. Kinase activity controls many of the signaling pathways responsible for major processes associated with cell growth, proliferation, differentiation, and metabolism. However, despite the growing number of inhibitors, many limitations remain in this field. The development of resistance based on intrinsic and extrinsic pathways, genomic alterations of the primary target, and a short response to targeted therapies due to the activation of compensatory signaling pathways are among the main issues.

The aim of this Special Issue is to highlight original research papers and review articles that provide new insights into the discovery of novel protein kinase inhibitors, as well as their application in targeted cancer therapies. Contributions to this Special Issue may focus on exploring new therapeutic targets or identifying novel small molecules, relevant mechanisms, or effective combination therapies.

Dr. Katarzyna Malarz
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • drug discovery
  • small molecules
  • anticancer activity
  • targeted cancer therapy
  • tyrosine kinase inhibitors
  • serine/threonine kinase inhibitors
  • allosteric inhibitors
  • signaling pathways
  • combination therapy
  • drug resistance

Related Special Issue

Published Papers

This special issue is now open for submission.
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