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Pharmaceutics
Special Issues
Application of Nanoparticles in Cancer Therapy and Diagnosis
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Application of Nanoparticles in Cancer Therapy and Diagnosis

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 7204

Special Issue Editors

Dr. Liane Isabel Ferreira Moura

E-Mail Website
Guest Editor
BioNanoSciences—Drug Delivery & Immunotherapy Group, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
Interests: cancer nanovaccines; cancer immunotherapy; targeted nanosystems; polymeric and polypeptide nanotechnology; nanotechnology approaches in diabetic wound healing; pharmaceutic technology
Dr. Murtaza M. Tambuwala

E-Mail Website
Guest Editor
School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, UK
Interests: nanoparticles; anti-inflamamtory; anti-cancer; anti-microbials; drug delviery; biomedical engineering; 3D printing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Several studies have demonstrated that the trapping of anticancer medications in submicronic colloidal systems, such as nanoparticles, can help to regulate both the tissue and cell distribution characteristics of these treatments. The overall goal of this strategy is to improve antitumor effectiveness while minimising systemic adverse effects. Additionally, nanoparticles are useful for the targeted delivery of oligonucleotides to tumour cells. Furthermore, several types of nanoparticles have shown an intriguing ability to overcome MDR resistance, a significant issue in chemotherapy. Polymeric nanoparticles, liposomes, dendrimers, nano-shells, carbon nanotubes, superparamagnetic nanoparticles, and nucleic acid-based nanoparticles (DNA, RNA interference (RNAi), and antisense oligonucleotide (ASO)) are examples of current nanotechnology platforms used for anticancer drug delivery. Recently, nanotechnologies are also being used in combination therapeutic strategies, such as ultrasound, hyperthermia, or photodynamic therapy. Decorating nanoparticles with a molecular ligand for the 'active' targeting of cancerous cells is considered as the next step in developing better cancer targeting strategies using nanoparticles. Applying nanoparticles in imaging for cancer diagnosis could lead to early detection and, consequently, improved cancer management.

Dr. Liane Isabel Ferreira Moura
Dr. Murtaza M. Tambuwala
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • nanoparticles
  • tumor targeting
  • decorated nanoparticles
  • natural compounds
  • cancer diagnostics
  • 3D models
  • bioprinting
  • drug resistance

Published Papers (3 papers)

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Review

23 pages, 5596 KiB  
Review
Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy
by Yedi Herdiana, Nasrul Wathoni, Dolih Gozali, Shaharum Shamsuddin and Muchtaridi Muchtaridi
Pharmaceutics 2023, 15(3), 879; https://doi.org/10.3390/pharmaceutics15030879 - 08 Mar 2023
Cited by 8 | Viewed by 2652
Abstract
Despite recent advances, cancer remains the primary killer on a global scale. Numerous forms of research have been conducted to discover novel and efficient anticancer medications. The complexity of breast cancer is a major challenge which is coupled with patient-to-patient variations and heterogeneity [...] Read more.
Despite recent advances, cancer remains the primary killer on a global scale. Numerous forms of research have been conducted to discover novel and efficient anticancer medications. The complexity of breast cancer is a major challenge which is coupled with patient-to-patient variations and heterogeneity between cells within the tumor. Revolutionary drug delivery is expected to provide a solution to that challenge. Chitosan nanoparticles (CSNPs) have prospects as a revolutionary delivery system capable of enhancing anticancer drug activity and reducing negative impacts on normal cells. The use of smart drug delivery systems (SDDs) as delivering materials to improve the bioactivity of NPs and to understand the intricacies of breast cancer has garnered significant interest. There are many reviews about CSNPs that present various points of view, but they have not yet described a series in cancer therapy from cell uptake to cell death. With this description, we will provide a more complete picture for designing preparations for SDDs. This review describes CSNPs as SDDSs, enhancing cancer therapy targeting and stimulus response using their anticancer mechanism. Multimodal chitosan SDDs as targeting and stimulus response medication delivery will improve therapeutic results. Full article
(This article belongs to the Special Issue Application of Nanoparticles in Cancer Therapy and Diagnosis)
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19 pages, 2720 KiB  
Review
Polysaccharide-Based Nanomedicines Targeting Lung Cancer
by Asif Ahmad Bhat, Gaurav Gupta, Khalid Saad Alharbi, Obaid Afzal, Abdulmalik S. A. Altamimi, Waleed Hassan Almalki, Imran Kazmi, Fahad A. Al-Abbasi, Sami I. Alzarea, Dinesh Kumar Chellappan, Sachin Kumar Singh, Ronan MacLoughlin, Brian G Oliver and Kamal Dua
Pharmaceutics 2022, 14(12), 2788; https://doi.org/10.3390/pharmaceutics14122788 - 13 Dec 2022
Cited by 41 | Viewed by 2176
Abstract
A primary illness that accounts for a significant portion of fatalities worldwide is cancer. Among the main malignancies, lung cancer is recognised as the most chronic kind of cancer around the globe. Radiation treatment, surgery, and chemotherapy are some medical procedures used in [...] Read more.
A primary illness that accounts for a significant portion of fatalities worldwide is cancer. Among the main malignancies, lung cancer is recognised as the most chronic kind of cancer around the globe. Radiation treatment, surgery, and chemotherapy are some medical procedures used in the traditional care of lung cancer. However, these methods lack selectivity and damage nearby healthy cells. Several polysaccharide-based nanomaterials have been created to transport chemotherapeutics to reduce harmful and adverse side effects and improve response during anti-tumour reactions. To address these drawbacks, a class of naturally occurring polymers called polysaccharides have special physical, chemical, and biological characteristics. They can interact with the immune system to induce a better immunological response. Furthermore, because of the flexibility of their structures, it is possible to create multifunctional nanocomposites with excellent stability and bioavailability for the delivery of medicines to tumour tissues. This study seeks to present new views on the use of polysaccharide-based chemotherapeutics and to highlight current developments in polysaccharide-based nanomedicines for lung cancer. Full article
(This article belongs to the Special Issue Application of Nanoparticles in Cancer Therapy and Diagnosis)
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20 pages, 2062 KiB  
Review
The Therapeutic Potential of Chemo/Thermotherapy with Magnetoliposomes for Cancer Treatment
by Alfonso Toro-Córdova, Monserrat Llaguno-Munive, Rafael Jurado and Patricia Garcia-Lopez
Pharmaceutics 2022, 14(11), 2443; https://doi.org/10.3390/pharmaceutics14112443 - 11 Nov 2022
Cited by 9 | Viewed by 1685
Abstract
Cancer represents a very grave and quickly growing public health problem worldwide. Despite the breakthroughs in treatment and early detection of the disease, an increase is projected in the incidence rate and mortality during the next 30 years. Thus, it is important to [...] Read more.
Cancer represents a very grave and quickly growing public health problem worldwide. Despite the breakthroughs in treatment and early detection of the disease, an increase is projected in the incidence rate and mortality during the next 30 years. Thus, it is important to develop new treatment strategies and diagnostic tools. One alternative is magnetic hyperthermia, a therapeutic approach that has shown promising results, both as monotherapy and in combination with chemo- and radiotherapy. However, there are still certain limitations and questions with respect to the safety of the systemic administration of magnetic nanoparticles. To deal with these issues, magnetoliposomes were conceived as a new generation of liposomes that incorporate superparamagnetic nanoparticles and oncological pharmaceuticals within their structure. They have the advantage of targeted and selective drug delivery to the diseased organs and tissues. Some of them can avoid the immune response of the host. When exposed to a magnetic field of alternating current, magnetoliposomes produce hyperthermia, which acts synergistically with the released drug. The aim of the present review is to describe the most recent advances in the use of magnetoliposomes and point out what research remains to be done for their application to chemo-thermal therapy in cancer patients. Full article
(This article belongs to the Special Issue Application of Nanoparticles in Cancer Therapy and Diagnosis)
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