Privileged Structures as Leads in Medicinal Chemistry 2023
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 5415
Special Issue Editors
Interests: synthesis; inorganic chemistry; medicinal chemistry; biochemistry; bioinorganic chemistry; metal complexes; cancer; phosphine; magnetic delivery system; drug carriers; nanoparticles
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Over the past few years, the privileged structure concept has emerged as a fruitful and interesting approach to the discovery of new biologically active molecules. Privileged structures are molecular scaffolds with various binding properties. Single scaffolds, owing to the modification of functional groups, are usually able to provide potent and selective ligands for a range of different biological targets. In addition, privileged structures typically exhibit good drug-like properties, which in turn lead to more drug-like compound libraries and leads. Nobel laureate James Whyte Black said that “the most fruitful basis for the discovery of a new drug is to start with an old”. The use of privileged structure scaffolds in medicinal chemistry embraces James Black’s statement, and despite numerous debates amongst medicinal chemists regarding the validity of the concept within drug discovery, it persists and continues to grow in popularity.
This “Privileged Structures as Leads in Medicinal Chemistry 2023” Special Issue welcomes articles addressing the synthesis, characterization, and application of privileged structures, both in traditional medicinal chemistry and in the design of focused libraries. Work that proposes new strategies that can lead to the discovery of new drugs is also welcome, and the identification as well as use of privileged structures, including molecular fragments that are able to interact with more than one target, are of particular interest.
Dr. Urszula K. Komarnicka
Dr. Sandra Kozieł
Guest Editors
Manuscript Submission Information
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Keywords
- medicinal chemistry
- privileged structures
- molecular targets
- drugs
- biological activity
