Medicinal Chemistry
A section of Pharmaceuticals (ISSN 1424-8247).
Section Information
The section of Medicinal Chemistry welcomes manuscripts involving aspects within the definition of medicinal chemistry related to the invention, discovery, design, identification and preparation of biologically active compounds, the study of their metabolism, the interpretation of their mode of action at the molecular level and the construction of structure-activity relationships. Novel strategies and methodologies with relevant application to chemical biology and medicinal chemistry are also welcome.
Our aim is to publish updated reviews as well as research articles with comprehensive theoretical and experimental details covering all aspects of small molecules as drug candidates e.g. drug discovery and design, combinatorial chemistry, structure-property correlations, molecular modelling and bioinformatics. Short communications are also accepted; therefore, there is no restriction on the length of a paper.
Keywords
- New synthetic routes for drug candidates
- Lead discovery and optimization methods; structure–activity relationships and QSAR
- Structure-based drug design, molecular modelling, docking studies and crystal structure analysis
- Identification and validation of novel drug targets, and high-throughput screening
- Virtual screening, database mining, and machine learning in drug discovery
- Role of ADMET in drug discovery
- Chemical biology and chemical probes
Editorial Board
Topical Advisory Panel
Special Issues
Following special issues within this section are currently open for submissions:
- Nano-Strategies in Fighting Cancer (Deadline: 22 April 2024)
- Drug Design Targeting Phosphodiesterase (Deadline: 22 April 2024)
- 20th Anniversary of Pharmaceuticals—Green Techniques for Organic and Organometallic/Coordination Synthesis and Medicinal Chemistry (Deadline: 25 April 2024)
- Histamine Receptor Ligands in Medicinal Chemistry (Deadline: 25 April 2024)
- Selective Histone Deacetylase Isoforms as Potential Therapeutic Targets (Deadline: 30 April 2024)
- Therapeutic Potential of Vitamin D in Depressive Disorder and Anxiety Disorders (Deadline: 15 May 2024)
- Drug Candidates for the Treatment of Obesity 2024 (Deadline: 20 May 2024)
- Alzheimer’s Disease: Small-Molecule Modulators of Novel Therapeutic Pathways (Deadline: 20 May 2024)
- Multidrug Resistance in Bacteria and New Therapeutic Options (Deadline: 20 May 2024)
- State of the Art of Medicinal Chemistry in Portugal (Deadline: 24 May 2024)
- Recent Advances in the Synthesis and Evaluation of Beta-Lactamase Inhibitors (Deadline: 25 May 2024)
- Selected Papers from the 9th International Electronic Conference on Medicinal Chemistry (ECMC2023) (Deadline: 25 May 2024)
- Hybrid Drugs: Design and Applications 2024 (Deadline: 25 May 2024)
- Topoisomerases as Targets for Novel Drug Discovery (Deadline: 30 May 2024)
- Recent Advances in Nuclear Factor Kappa-B (NF-kB) Inhibitors for Cancer Therapy (Deadline: 30 May 2024)
- Application of 2D and 3D-QSAR Models in Drug Design (Deadline: 31 May 2024)
- Recent Efforts in Drug Discovery and Development for the Treatment of Parasitic Infections (Deadline: 31 May 2024)
- 20th Anniversary of Pharmaceuticals—Recent Advances in Metallodrug Design and Application (Deadline: 31 May 2024)
- Drug Development Targeting the Metabolic Nuclear Receptors: Recent Advances (Deadline: 1 June 2024)
- Structure and Ligand Based Drug Design (Deadline: 10 June 2024)
- Advanced Strategies in Drug Design and Development of Small Molecules as Therapeutic Agents (Deadline: 20 June 2024)
- Choline Kinase as a Therapeutic Target (Deadline: 20 June 2024)
- Design, Synthesis and Biological Evaluation with Potential Anti-inflammatory Activity (Deadline: 22 June 2024)
- Design and Synthesis of Small Molecule Kinase Inhibitors (Deadline: 25 June 2024)
- Metal-Based Agents in Drug Discovery 2024 (Deadline: 25 June 2024)
- Drug Candidates for the Treatment of Oral Cancer and Oral Cancer Pain (Deadline: 25 June 2024)
- Pyrazole and Thiazole Derivatives in Medicinal Chemistry (Deadline: 25 June 2024)
- Small Molecules in Cancer Immunotherapy (Deadline: 25 June 2024)
- Novel Anti-proliferative Agents 2024 (Deadline: 25 June 2024)
- The 20th Anniversary of Pharmaceuticals—Metal-Based Drugs for Cancer Treatment, Antibacterial and Antiviral Applications (Deadline: 25 June 2024)
- Modern Approach to Neuroendocrine Neoplasms Diagnosis and Treatment (Deadline: 25 June 2024)
- Recent Advancements in the Development of Antiprotozoal Agents (Deadline: 30 June 2024)
- Molecular Systems for the Delivery of Drugs and Contrast Agents (Deadline: 30 June 2024)
- Heterocyclic Compounds in Medicinal Chemistry (Deadline: 30 June 2024)
- Computer-Aided Molecular Modeling and Simulation in Drug Design (Deadline: 30 June 2024)
- Sex Differences in Pharmaceutical Practice (Deadline: 30 June 2024)
- Computer-Aided Drug Design and Drug Discovery (Deadline: 10 July 2024)
- Discovery of Natural Products as Potential Antidiabetic Agents (Deadline: 15 July 2024)
- Novel Imidazole Derivatives in Medicinal Chemistry (Deadline: 15 July 2024)
- Inhibitors of κB Kinase (IKK) and Nuclear Factor Kappa-B (NF-κB): Attractive Drug Targets (Deadline: 20 July 2024)
- Design, Synthesis, Evaluation and Biopharmaceutical Uses of Imatinib, Nilotinib and Their Analogues (Deadline: 22 July 2024)
- Multitargeted Compounds: A Promising Approach in Medicinal Chemistry (Deadline: 25 July 2024)
- Mitochondrial Protease ClpP in Antitumor-Drug Development: Recent Advances and Challenges (Deadline: 25 July 2024)
- Enzyme Inhibitors: Potential Therapeutic Approaches (Deadline: 25 July 2024)
- Recent Developments of Chalcones and Their Derivatives in Medicinal Chemistry (Deadline: 25 July 2024)
- Amyloid Composition and Structure-Based Development of Therapeutic and Diagnostic Agents (Deadline: 25 July 2024)
- New Perspectives on Chemoinformatics and Drug Design (Deadline: 25 July 2024)
- Medicinal Chemistry and Pharmacological Activities of Heparin and Related Drugs (Deadline: 25 July 2024)
- Heterocyclic Compounds in Medicinal Chemistry: New Advances (Deadline: 25 July 2024)
- Drug Candidates for the Treatment of Immune Disease 2023 (Deadline: 26 July 2024)
- Drug Discovery of Antiprotozoal Agents 2024 (Deadline: 31 July 2024)
- Therapeutic Potential of Silver Nanoparticles (AgNPs) (Deadline: 31 July 2024)
- Medicinal Metal Ions and Metal-Based Complex (Deadline: 31 July 2024)
- Nitrogen Containing Scaffolds in Medicinal Chemistry 2023 (Deadline: 31 July 2024)
- Metal Chelating Agents in Medicinal Chemistry (Deadline: 31 July 2024)
- Targeting Opioid Receptors for Innovative Therapies: Present and Emerging Concepts in Opioid Cure (Deadline: 31 July 2024)
- Emerging Trends in Liquid Chromatography and Mass Spectrometry-Based Analyses of Pharmaceuticals (Deadline: 20 August 2024)
- Current Advances, Applications and Future Development of Transition Metal Complexes (Deadline: 20 August 2024)
- Organochalcogen Molecules and Materials in Medicinal Chemistry (Deadline: 25 August 2024)
- Boron in Medicinal Chemistry: From Synthesis to Therapeutic Applications (Deadline: 25 August 2024)
- Prodrugs: Design and Development (Deadline: 25 August 2024)
- Discovery and Biochemical Profiling of Marine Drugs (Deadline: 25 August 2024)
- Multicomponent and Domino Reactions in Drug Discovery (Deadline: 25 August 2024)
- Chirality: The Important Factor for Drug Discovery and Development (Deadline: 25 August 2024)
- Antioxidants in the Processes of Retarding Ageing (Deadline: 28 August 2024)
- The 20th Anniversary of Pharmaceuticals—Advances in Medicinal Chemistry (Deadline: 30 August 2024)
- Amyloid Beta: New Rational Structure-Based Therapeutic Development (Deadline: 30 August 2024)
- Recent Advances and Future Approaches in Preventive and Therapeutic Effects of Vanadium Complexes (Deadline: 31 August 2024)
- The 20th Anniversary of Pharmaceuticals—Heterocyclic Compounds and Their Application in Therapy (Deadline: 31 August 2024)
- Recent Advances in the Discovery and Development of Drugs for Civilization Diseases (Deadline: 1 September 2024)
- Emerging Drug Candidates and Therapeutic Approaches for Ocular Disorders (Deadline: 13 September 2024)
- Hit to Lead Design of New Anti-Infective Drugs (Deadline: 15 September 2024)
- Sulfur-Containing Scaffolds in Medicinal Chemistry (Deadline: 20 September 2024)
- Metal Nanoparticles’ Biological Activity and Pharmaceutical Applications (Deadline: 20 September 2024)
- New Approaches to Fighting Infectious Diseases: Overcoming the Antimicrobial Resistance in Current Treatments (Deadline: 20 September 2024)
- Small Molecule Drug Discovery: Driven by In-Silico Techniques (Deadline: 25 September 2024)
- Synthetic Inhibitors of Nucleoside Monophosphate-Kinases (Deadline: 25 September 2024)
- The Role of Molecular Docking in the Design of Targeted Therapeutic Entities and Nanomaterials (Deadline: 25 September 2024)
- Classical and Quantum Molecular Simulations in Drug Design (Deadline: 30 September 2024)
- Advances and Future Trends in Development of Novel Antifungals and Antifungal Therapy (Deadline: 30 September 2024)
- Flavonoids in Medicinal Chemistry: Trends and Future Directions (Deadline: 30 September 2024)
- 20th Anniversary of Pharmaceuticals–Drug Design and Pharmacological Advances in Neurodegenerative Disease (Deadline: 20 October 2024)
- Design, Synthesis and Biological Assessment of Amphiphiles (Deadline: 30 October 2024)
- Design, Synthesis and Development of Novel Antiviral Agents (Deadline: 30 October 2024)
- Advances in Peptide Chemistry and Medicinal Application (Deadline: 30 November 2024)
- Antiviral Agents, 2024 (Deadline: 30 November 2024)
- Inhibition and Treatment in Adhesion, Migration, Invasion, and Metastasis of Cancer Cells (Deadline: 13 December 2024)
- Recent Advances in Psychiatric Medications (Deadline: 31 December 2024)
Topical Collections
Following topical collections within this section are currently open for submissions:
