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Pathogens
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Detection of SARS-CoV-2 Variants of Concern (VOCs) in Wastewater
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Detection of SARS-CoV-2 Variants of Concern (VOCs) in Wastewater

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Emerging Pathogens".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 1964

Special Issue Editor

Dr. Samendra Sherchan

E-Mail Website
Guest Editor
1. Department of Environmental Health Sciences, Tulane University, 1440 Canal Street, New Orleans, LA 70112, USA
2. BioEnvironmental Science Program, Morgan State University, Baltimore, MD 21251, USA
Interests: wastewater based epidemiology; climate change; infectious diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Wastewater surveillance of SARS-CoV-2 is a hot topic and it can be used by public health officials as an early warning tool.  However, there are several emerging Variants of Concern (VOCs) of SARS-CoV-2, including Alpha, Delta and Omicron, that constrain the global public health response towards the COVID-19 pandemic.

There are currently five Variants of Concern (VOCs, including Alpha, Beta, Gamma, Delta and Omicron)  and several Variants of Interests (VOIs) of the SAR-CoV-2 virus designated by WHO (https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/).

Detecting these VOCs in wastewater is an ongoing challenge. Multiple molecular methods have been deployed for the detection of SARS-CoV-2 variants, including RT-qPCR, RT-ddPCR, and next-generation sequencing, but there is no single approved standard method.

Furthermore, significant research is needed to improve the detection of SARS-CoV-2 variants in wastewater.

To address these needs for monitoring SARS-CoV-2 variants, we would like to invite research articles or review papers focused on various aspects including, but not limited to:

  • Rapid detection and identification methods for VOCs;
  • Next-generation-sequencing-based methods;
  • Tracking SARS-CoV-2 variants in LMICs;
  • Optimisation of conventional methods.

Dr. Samendra Sherchan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wastewater surveillance
  • emerging variants of concern
  • Alpha
  • Delta
  • Omicron

Related Special Issue

Published Papers (1 paper)

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Research

14 pages, 2075 KiB  
Article
The Detection of Periodic Reemergence Events of SARS-CoV-2 Delta Strain in Communities Dominated by Omicron
by Claire E. Westcott, Kevin J. Sokoloski, Eric C. Rouchka, Julia H. Chariker, Rochelle H. Holm, Ray A. Yeager, Joseph B. Moore IV, Erin M. Elliott, Daymond Talley, Aruni Bhatnagar and Ted Smith
Pathogens 2022, 11(11), 1249; https://doi.org/10.3390/pathogens11111249 - 28 Oct 2022
Cited by 7 | Viewed by 1489
Abstract
Despite entering an endemic phase, SARS-CoV-2 remains a significant burden to public health across the global community. Wastewater sampling has consistently proven utility to understanding SARS-CoV-2 prevalence trends and genetic variation as it represents a less biased assessment of the corresponding communities. Here, [...] Read more.
Despite entering an endemic phase, SARS-CoV-2 remains a significant burden to public health across the global community. Wastewater sampling has consistently proven utility to understanding SARS-CoV-2 prevalence trends and genetic variation as it represents a less biased assessment of the corresponding communities. Here, we report that ongoing monitoring of SARS-CoV-2 genetic variation in samples obtained from the wastewatersheds of the city of Louisville in Jefferson county Kentucky has revealed the periodic reemergence of the Delta strain in the presence of the presumed dominant Omicron strain. Unlike previous SARS-CoV-2 waves/emergence events, the Delta reemergence events were geographically restricted in the community and failed to spread into other areas as determined by wastewater analyses. Moreover, the reemergence of the Delta strain did not correlate with vaccination rates as communities with lower relative vaccination have been, to date, not affected. Importantly, Delta reemergence events correlate with increased public health burdens, as indicated by increased daily case rates and mortality relative to non-Delta wastewatershed communities. While the underlying reasons for the reemergence of the Delta variant remain unclear, these data reaffirm the ongoing importance of wastewater genomic analyses towards understanding SARS-CoV-2 as it enters the endemic phase. Full article
(This article belongs to the Special Issue Detection of SARS-CoV-2 Variants of Concern (VOCs) in Wastewater)
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