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Pathogens
Special Issues
Nutrient Uptake and Trafficking in Plasmodium Species
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Nutrient Uptake and Trafficking in Plasmodium Species

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 10 May 2024 | Viewed by 3668

Special Issue Editor

Prof. Dr. Tobili Y. Sam-Yellowe

E-Mail Website
Guest Editor
Department of Biological, Geological, and Environmental Sciences, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH 44115, USA
Interests: Plasmodium species; malaria immunology; cell biology and molecular biology

Special Issue Information

Dear Colleagues,

This Special Issue will explore the mechanisms of nutrient uptake and trafficking in Plasmodium species. Plasmodium species take up nutrients and ions through the host erythrocyte membrane, across the parasitophorous vacuole (PV) for traffic and delivery to the parasite for intracellular growth. In addition to the nutrient channels formed, it is unclear if the Maurer’s clefts and other parasite-derived tubular membranes formed in the erythrocyte cytosol participate in nutrient uptake and transport. Proteins of the high molecular weight rhoptry protein complex (RhopH) are reported to participate in nutrient uptake and merozoite invasion. However, other parasite proteins may associate with RhopH proteins to facilitate channel formation and nutrient transport. Studies investigating nutrient uptake and transport with the use of bioinformatics approaches including proteomics, transcriptomics, and other -omics methodologies may shed light on protein-protein and protein-lipid interactions and identify proteins required for channel formation, nutrient uptake, nutrient traffic, and nutrient processing for the developing intracellular parasite. Studies focused on heterologous molecular and cellular systems will provide an understanding of underlying mechanisms involved in the process of nutrient uptake and the types of nutrients transported. Studies addressing different aspects of nutrient uptake, traffic, and channel formation in Plasmodium-infected erythrocytes submitted for this Special Issue of Pathogens will provide timely and cutting-edge research that will inform the biology of Plasmodium species and provide strategies for the delivery of anti-plasmodial agents for malaria therapy.

Prof. Dr. Tobili Y. Sam-Yellowe
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Plasmodium species
  • bioinformatics
  • integral membrane proteins
  • nutrient uptake
  • nutrient channels
  • nutrient transport
  • rhoptry proteins
  • RhopH protein complex
  • membrane transporters
  • Maurer's clefts

Published Papers (3 papers)

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Editorial

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4 pages, 197 KiB  
Editorial
From Myzocytosis to Cytostomal Nutrient Uptake and Transport by Intracellular Plasmodium Species
by Tobili Y. Sam-Yellowe
Pathogens 2023, 12(8), 1036; https://doi.org/10.3390/pathogens12081036 - 14 Aug 2023
Viewed by 869
Abstract
Plasmodium falciparum causes severe and lethal malaria [...] Full article
(This article belongs to the Special Issue Nutrient Uptake and Trafficking in Plasmodium Species)

Review

Jump to: Editorial

14 pages, 1976 KiB  
Review
The Digestive Vacuole of the Malaria Parasite: A Specialized Lysosome
by Mark F. Wiser
Pathogens 2024, 13(3), 182; https://doi.org/10.3390/pathogens13030182 - 20 Feb 2024
Viewed by 1268
Abstract
The malaria parasite resides within erythrocytes during one stage of its life cycle. During this intraerythrocytic period, the parasite ingests the erythrocyte cytoplasm and digests approximately two-thirds of the host cell hemoglobin. This digestion occurs within a lysosome-like organelle called the digestive vacuole. [...] Read more.
The malaria parasite resides within erythrocytes during one stage of its life cycle. During this intraerythrocytic period, the parasite ingests the erythrocyte cytoplasm and digests approximately two-thirds of the host cell hemoglobin. This digestion occurs within a lysosome-like organelle called the digestive vacuole. Several proteases are localized to the digestive vacuole and these proteases sequentially breakdown hemoglobin into small peptides, dipeptides, and amino acids. The peptides are exported into the host cytoplasm via the chloroquine-resistance transporter and an amino acid transporter has also been identified on the digestive vacuole membrane. The environment of the digestive vacuole also provides appropriate conditions for the biocrystallization of toxic heme into non-toxic hemozoin by a poorly understood process. Hemozoin formation is an attribute of Plasmodium and Haemoproteus and is not exhibited by other intraerythrocytic protozoan parasites. The efficient degradation of hemoglobin and detoxification of heme likely plays a major role in the high level of replication exhibited by malaria parasites within erythrocytes. Unique features of the digestive vacuole and the critical importance of nutrient acquisition provide therapeutic targets for the treatment of malaria. Full article
(This article belongs to the Special Issue Nutrient Uptake and Trafficking in Plasmodium Species)
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11 pages, 563 KiB  
Review
Unique Properties of Nutrient Channels on Plasmodium-Infected Erythrocytes
by Sanjay Arvind Desai
Pathogens 2023, 12(10), 1211; https://doi.org/10.3390/pathogens12101211 - 02 Oct 2023
Cited by 2 | Viewed by 1003
Abstract
Intracellular malaria parasites activate an ion and organic solute channel on their host erythrocyte membrane to acquire a broad range of essential nutrients. This plasmodial surface anion channel (PSAC) facilitates the uptake of sugars, amino acids, purines, some vitamins, and organic cations, but [...] Read more.
Intracellular malaria parasites activate an ion and organic solute channel on their host erythrocyte membrane to acquire a broad range of essential nutrients. This plasmodial surface anion channel (PSAC) facilitates the uptake of sugars, amino acids, purines, some vitamins, and organic cations, but remarkably, it must exclude the small Na+ ion to preserve infected erythrocyte osmotic stability in plasma. Although molecular, biochemical, and structural studies have provided fundamental mechanistic insights about PSAC and advanced potent inhibitors as exciting antimalarial leads, important questions remain about how nutrients and ions are transported. Here, I review PSAC’s unusual selectivity and conductance properties, which should guide future research into this important microbial ion channel. Full article
(This article belongs to the Special Issue Nutrient Uptake and Trafficking in Plasmodium Species)
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