T Cell Responses to Pathogenic Infections
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Immunological Responses and Immune Defense Mechanisms".
Deadline for manuscript submissions: 15 May 2024 | Viewed by 1277
Special Issue Editor
Interests: adaptive immunity; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
T cells play a central role in the immune response against pathogenic infections, and T-cell-based therapy has shown great potential as a more powerful approach to treating various pathogenic diseases by harnessing the body's immune system. It is anticipated that the responses initiated by immunotherapeutic interventions will explicitly demonstrate the ability to discerningly suppress the individual disease while maintaining the rest of the immune system in a functionally active state. Increasing our knowledge of cellular immunology and the host immune response has led to the exciting development of diverse immunotherapeutic modalities, including the blockade of immune checkpoints, the induced activation of CD8 + cytotoxic T lymphocytes (CTLs) or CD4 + regulatory T cells (Tregs), the use of non-specific immunosuppressive drugs with associated side effects (e.g., anti-CD3, CD20, or CD52 antibody), adoptive T-cell transfer (ACT)-based therapy, and the modulation of the local environment, including the tumor microenvironment (TME) and the inflammatory microenvironment (IME), to facilitate T cell immunity (e.g., low-dose IL-2 treatment). However, despite the advances in T-cell-based therapy, the clinical efficacy and benefits remain less satisfactory due to a variety of factors that lessen antiviral immunity, which include ex vivo T cell production, limited in vivo T cell expansion and persistence, auto antigen identification, the generation of antigen-specific T cells, off-target complications, local environment, T cell trafficking to local sites, etc. Effective strategies to bypass these barriers should significantly improve T-cell-based immunotherapy for pathogenic diseases, and are thus urgently needed.
Prof. Dr. Jianxun Song
Guest Editor
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Keywords
- pathogen
- T cell
- immunotherapy
- persistence
- cell metabolism
- immunomodulation
- exhaustion
- memory
- animal model
