Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.1
3.7
Journals
Pathogens
Special Issues
Human Papillomavirus Infection and Vaccine Research
share announcement

Human Papillomavirus Infection and Vaccine Research

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Vaccines and Therapeutic Developments".

Deadline for manuscript submissions: 15 September 2024 | Viewed by 756

Special Issue Editor

Dr. Yao-Min Hung

E-Mail
Guest Editor
Department of Internal Medicine, Taipei Veterans General Hospital Taitung Branch, Taitung 95050, Taiwan
Interests: human papillomavirus infection; HPV vaccine; COVID-19; COVID-19 vaccination; salmonellosis; epidemiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Human papillomaviruses (HPV) are a large family of widespread, non-enveloped, double-stranded DNA viruses that persistently infect and replicate in differentiated skin and mucosal epithelia. HPV infection is associated with a variety of diseases, including several types of cancer and some autoimmune disorders.

HPV vaccines were developed to prevent infection and subsequent HPV-related diseases. Since the first HPV vaccine was approved in 2006, there are now four HPV vaccines on the drug market. Global HPV vaccination coverage varies by country.

Therefore, this Special Issue focuses on the prevention, epidemiology, and control of HPV infection and HPV vaccine research. We welcome the submission of original research and review manuscripts covering any aspect related to this Special Issue.

We are interested in a broad area of research about HPV infection and HPV vaccine research, which is important and necessary for human health.

Dr. Yao-Min Hung
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epidemiology
  • human papillomavirus infection
  • HPV-related diseases
  • vaccine research
  • HPV vaccine safety
  • HPV vaccine effectiveness

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

12 pages, 4213 KiB  
Communication
FAM19A4 and hsa-miR124-2 Double Methylation as Screening for ASC-H- and CIN1 HPV-Positive Women
by Cinzia Peronace, Erika Cione, Diana Marisol Abrego-Guandique, Marco De Fazio, Giuseppina Panduri, Maria Cristina Caroleo, Roberto Cannataro and Pasquale Minchella
Pathogens 2024, 13(4), 312; https://doi.org/10.3390/pathogens13040312 - 11 Apr 2024
Viewed by 554
Abstract
The DNA methylation levels of host cell genes increase with the severity of the cervical intraepithelial neoplasia (CIN) grade and are very high in cervical cancer. Our study aims to evaluate FAM19A4 and hsa-miR124-2 methylation in Atypical Squamous cells with high-grade squamous intraepithelial [...] Read more.
The DNA methylation levels of host cell genes increase with the severity of the cervical intraepithelial neoplasia (CIN) grade and are very high in cervical cancer. Our study aims to evaluate FAM19A4 and hsa-miR124-2 methylation in Atypical Squamous cells with high-grade squamous intraepithelial lesions (ASC-H) and in CIN1, defined as low-grade squamous intraepithelial lesions (LSILs) by the Bethesda classification, as possible early warning biomarkers for managing women with high-risk HPV infections (hrHPV). FAM19A4 and hsa-miR124-2 methylation tests were conducted on fifty-six cervical screening samples from a subset of women aged 30–64 years old. Specimens were collected into ThinPrep PreservCyt Solution. Their HrHPV genotype and cytology diagnosis were known. A Qiasure (Qiagen) was used for FAM19A4 and hsa-miR124-2 methylation testing on bisulfite-converted DNA, according to the manufacturer’s specifications. The reported results were hypermethylation-positive or -negative. We found that FAM194A4 and hsa-miR124-2 methylation was detected in 75% of ASC-H cases with a persistent infection of hrHPV. A total of 60% of CIN1 lesions were found to be positive for methylation, and 83.3% were when the cytology was CIN2/3. In addition, as a novelty of this pilot study, we found that combined FAM19A4 and hsa-miR124-2 methylation positivity rates (both methylated) were associated with the HPV genotypes 16, 18, and 59 and covered 22 and 25% of ASC-H and CIN1 cases, respectively. The methylation of these two genes, in combination with HPV genotyping, can be used as an early warning biomarker in the management and follow-up of women with ASC-H and CIN1 to avoid their progression to cervical cancer. Full article
(This article belongs to the Special Issue Human Papillomavirus Infection and Vaccine Research)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop