Special Issue "Selected Papers from IEEE BIBM 2021 Workshop on Long Non-coding RNAs: Mechanism, Function, and Computational Analysis (BIBM-LncRNA)"
A special issue of Non-Coding RNA (ISSN 2311-553X).
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 6677
Interests: machine learning & computer vision; search algorithms & data structures; bioinformatics & computational biology; digital health
Interests: bioinformatics; systems biology; imaging informatics; clinical informatics
Interests: miRNA biogenesis; lncRNA and cancer; human papillomavirus; coronaviruses; lung cancer; quiescence; senescence
Interests: lncRNA; long non-coding RNA; lincRNA; primate-specific genes; antisense; RNA therapeutics; precision medicine; GWAS; cancer; diabetes; transcriptome; proteogenomics
Interests: genetics; genomics; bioinformatics; biomedicine; synthetic biology; theoretical biology
This Special Issue comprises extended versions of selected papers and presentations from the IEEE BIBM 2021 Workshop on Long Non-Coding RNAs: Mechanism, Function, and Computational Analysis (BIBM-LncRNA), held on 9–12 December 2021, (https://community.wvu.edu/~daadjeroh/workshops/LNCRNA2021/). The LncRNA workshop was held in a mixed mode: both virtual/remote and face-to-face in Dubai, UAE.
Recent applications of high-throughput technologies in transcriptomics have changed our view of gene regulation and function. The discovery of the extensive transcription of large RNA transcripts, termed long noncoding RNAs (lncRNAs), has provided an important and novel perspective on the centrality of RNAs in gene regulation. LncRNAs are involved in various biological and cellular processes, such as genetic imprinting, chromatin remodeling, gene regulation and embryonic development. LncRNAs have been implicated in several chronic diseases, such as cancers, heart disease, etc. Given the abundance of lncRNAs, tens of thousands still need to be functionally characterized. Various types of genomic data on lncRNAs are currently available, including sequences, secondary/tertiary structures, transcriptome data, and their interactions with related proteins or genes. A key challenge is how to integrate data from a myriad of sources to determine the functions and regulatory mechanism of these ubiquitous lncRNAs. Computational studies of lncRNA secondary, tertiary structure, and lncRNA interactions with other molecules are in their infancy, and more work is still needed.
Authors of selected papers and invited presentations at the workshop were invited to submit extended versions of their work, including comprehensive review papers and research articles with unpublished, original research describing recent advances on topics related to this workshop, including, but not limited to:
- lncRNA detection and biomarker discovery;
- CLIP-Seq and RIP-Seq data analysis;
- Prediction of physical binding between lncRNAs and DNAs and RNAs and protein;
- Competition and interactions between lncRNA, miRNA, and mRNA;
- Studying methylation regulating lncRNA functions;
- Function prediction for lncRNAs;
- Deep learning approaches to lncRNA/RNA binding protein prediction;
- Computational approaches to analyzing lncRNAs;
- lncRNA 3D secondary structures;
- lncRNA–protein interactions;
- lncRNA in epigenetic regulation;
- lncRNA-associated disease network;
- lncRNAs in plant genomics;
- lncRNAs in phenotype–genotype problems;
- lncRNAs and single-cell transcriptomics;
- lncRNAs and spatial transcriptomics;
- CRISPR/Cas9 and genome editing in lncRNAs.
Selected papers and presentations that have attracted the most interest on the web or that provide a particularly innovative contribution were gathered for publication. These papers were subjected to a peer review and have been published with the aim of attaining a rapid and wide dissemination of research results, developments, and applications. In addition, authors could submit their extended papers to this Special Issue after the workshop, so there was no need to wait for the submission deadline. All papers accepted for publication will be immediately published.
Prof. Dr. Donald Adjeroh
Prof. Dr. Xiaobo Zhou
Dr. Ivan Martinez
Prof. Dr. Leonard Lipovich
Dr. Tatiana Shkurat
Dr. Ekaterina Derevyanchuk
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.