Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.4
4.5
Journals
Microorganisms
Special Issues
Control and Detection of Multiple Antibiotic Resistant Pathogens 2.0
share announcement

Control and Detection of Multiple Antibiotic Resistant Pathogens 2.0

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 17880

Special Issue Editor

Prof. Dr. Juhee Ahn

E-Mail Website
Guest Editor
Department of Medical Biomaterials Engineering, Kangwon National University, Chuncheon 24341, Gangwon, Republic of Korea
Interests: microbial pathogenesis; phage control; antibiotic resistance mechanism; food safety
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our 2020 Special Issue "Control and Detection of Multiple Antibiotic Resistant Pathogens".

Over the last several decades, the overuse and misuse of antibiotics have led to the increased emergence of antibiotic-resistant pathogens. The repeated exposure to therapeutic antibiotics provides selection pressure for the evolution of multiple antibiotic resistance in pathogenic bacteria, which can cause serious infectious diseases. Therefore, the development of effective control and rapid detection tools is essential for treatment and prevention of multiple antibiotic-resistant bacterial infections. Many control systems including combination therapy, phage control, and antibiotic resistance mechanism-based systems (efflux pump and b-lactamase inhibitors) have been designed to improve antibacterial activity against multiple antibiotic-resistant pathogens. Many different approaches have been tried to develop rapid, selective, and sensitive detection tools for multiple antibiotic-resistant pathogens, including nucleic acid probes, molecular-based techniques (gene amplification and microarray hybridization), chemical methods (thermostable nuclease, radiometry, and lux gene luminescence), and physical methods (impedance, microcalorimetry, and flow cytometry).

In this Special Issue of Microorganisms, we invite you to send contributions concerning any aspects related to the control and detection of multiple antibiotic-resistant pathogens, including effective control systems such as combination therapy and phage control and reliable qualitative and quantitative detection techniques such as molecular-based diagnostic tools. In addition, antibiotic mechanism-based studies are also welcome for this Special Issue.

Prof. Dr. Juhee Ahn
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibiotic resistance
  • bacteriophage
  • phage therapy
  • biofilm
  • resistance mechanism
  • resistance detection
  • phage-encoded enzyme
  • multidrug resistance

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

14 pages, 1432 KiB  
Article
Bacterial Bloodstream Infections after Allogeneic Hematopoietic Stem Cell Transplantation: Etiology, Risk Factors and Outcome in a Single-Center Study
by Jessica Gill, Alessandro Busca, Natascia Cinatti, Roberto Passera, Chiara Maria Dellacasa, Luisa Giaccone, Irene Dogliotti, Sara Manetta, Silvia Corcione and Francesco Giuseppe De Rosa
Microorganisms 2023, 11(3), 742; https://doi.org/10.3390/microorganisms11030742 - 14 Mar 2023
Cited by 4 | Viewed by 2102
Abstract
Background—Allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients are subject to major risks for bacterial bloodstream infections (BSIs), including emergent multidrug-resistant (MDR) organisms, which still represent the main cause of morbidity and mortality in transplanted patients. Methods: We performed an observational, retrospective, single-center study [...] Read more.
Background—Allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients are subject to major risks for bacterial bloodstream infections (BSIs), including emergent multidrug-resistant (MDR) organisms, which still represent the main cause of morbidity and mortality in transplanted patients. Methods: We performed an observational, retrospective, single-center study on patients undergoing allo-HSCT between 2004 and 2020 at the Stem Cell Transplant Unit in Turin to assess the incidence, etiology, and outcomes of BSIs and to explore any risk factors for bacteriaemia. Results: We observed a total of 178 bacterial BSIs in our cohort of 563 patients, resulting in a cumulative incidence of 19.4%, 23.8%, and 28.7% at 30, 100, and 365 days, respectively. Among isolated bacteria, 50.6% were Gram positive (GPB), 41.6% were Gram negative (GNB), and 7.9% were polymicrobial infections. Moreover, BSI occurrence significantly influenced 1-year overall survival. High and very high Disease Risk Index (DRI), an haploidentical donor, and antibacterial prophylaxis were found as results as independent risk factors for bacterial BSI occurrence in multivariate analysis. Conclusions: In our experience, GNB have overwhelmed GPB, and fluoroquinolone prophylaxis has contributed to the emergence of MDR pathogens. Local resistance patterns and patients’ characteristics should therefore be considered for better management of bacteremia in patients receiving an allogeneic HSCT. Full article
(This article belongs to the Special Issue Control and Detection of Multiple Antibiotic Resistant Pathogens 2.0)
►▼ Show Figures

Figure 1

Review

Jump to: Research

36 pages, 2149 KiB  
Review
Immunomodulatory Effects of Macrolides Considering Evidence from Human and Veterinary Medicine
by Joseph M. Blondeau
Microorganisms 2022, 10(12), 2438; https://doi.org/10.3390/microorganisms10122438 - 09 Dec 2022
Cited by 3 | Viewed by 2409
Abstract
Macrolide antimicrobial agents have been in clinical use for more than 60 years in both human and veterinary medicine. The discovery of the non-antimicrobial properties of macrolides and the effect of immunomodulation of the inflammatory response has benefited patients with chronic airway diseases [...] Read more.
Macrolide antimicrobial agents have been in clinical use for more than 60 years in both human and veterinary medicine. The discovery of the non-antimicrobial properties of macrolides and the effect of immunomodulation of the inflammatory response has benefited patients with chronic airway diseases and impacted morbidity and mortality. This review examines the evidence of antimicrobial and non-antimicrobial properties of macrolides in human and veterinary medicine with a focus toward veterinary macrolides but including important and relevant evidence from the human literature. The complete story for these complex and important molecules is continuing to be written. Full article
(This article belongs to the Special Issue Control and Detection of Multiple Antibiotic Resistant Pathogens 2.0)
►▼ Show Figures

Figure 1

21 pages, 2025 KiB  
Review
Systems Biology: New Insight into Antibiotic Resistance
by Piubeli Francine
Microorganisms 2022, 10(12), 2362; https://doi.org/10.3390/microorganisms10122362 - 29 Nov 2022
Cited by 6 | Viewed by 2490
Abstract
Over the past few decades, antimicrobial resistance (AMR) has emerged as an important threat to public health, resulting from the global propagation of multidrug-resistant strains of various bacterial species. Knowledge of the intrinsic factors leading to this resistance is necessary to overcome these [...] Read more.
Over the past few decades, antimicrobial resistance (AMR) has emerged as an important threat to public health, resulting from the global propagation of multidrug-resistant strains of various bacterial species. Knowledge of the intrinsic factors leading to this resistance is necessary to overcome these new strains. This has contributed to the increased use of omics technologies and their extrapolation to the system level. Understanding the mechanisms involved in antimicrobial resistance acquired by microorganisms at the system level is essential to obtain answers and explore options to combat this resistance. Therefore, the use of robust whole-genome sequencing approaches and other omics techniques such as transcriptomics, proteomics, and metabolomics provide fundamental insights into the physiology of antimicrobial resistance. To improve the efficiency of data obtained through omics approaches, and thus gain a predictive understanding of bacterial responses to antibiotics, the integration of mathematical models with genome-scale metabolic models (GEMs) is essential. In this context, here we outline recent efforts that have demonstrated that the use of omics technology and systems biology, as quantitative and robust hypothesis-generating frameworks, can improve the understanding of antibiotic resistance, and it is hoped that this emerging field can provide support for these new efforts. Full article
(This article belongs to the Special Issue Control and Detection of Multiple Antibiotic Resistant Pathogens 2.0)
►▼ Show Figures

Figure 1

19 pages, 1941 KiB  
Review
Bacteriophages as Biocontrol Agents in Livestock Food Production
by Logan Gildea, Joseph Atia Ayariga and Boakai K. Robertson
Microorganisms 2022, 10(11), 2126; https://doi.org/10.3390/microorganisms10112126 - 27 Oct 2022
Cited by 10 | Viewed by 3116
Abstract
Bacteriophages have been regarded as biocontrol agents that can be used in the food industry. They can be used in various applications, such as pathogen detection and bio-preservation. Their potential to improve the quality of food and prevent foodborne illness is widespread. These [...] Read more.
Bacteriophages have been regarded as biocontrol agents that can be used in the food industry. They can be used in various applications, such as pathogen detection and bio-preservation. Their potential to improve the quality of food and prevent foodborne illness is widespread. These bacterial viruses can also be utilized in the preservation of various other food products. The specificity and high sensitivity of bacteriophages when they lyse bacterial targets have been regarded as important factors that contribute to their great potential utility in the food industry. This review will provide an overview of their current and potential applications. Full article
(This article belongs to the Special Issue Control and Detection of Multiple Antibiotic Resistant Pathogens 2.0)
►▼ Show Figures

Figure 1

21 pages, 4384 KiB  
Review
Bacterial Stress Responses as Potential Targets in Overcoming Antibiotic Resistance
by Jirapat Dawan and Juhee Ahn
Microorganisms 2022, 10(7), 1385; https://doi.org/10.3390/microorganisms10071385 - 09 Jul 2022
Cited by 29 | Viewed by 7148
Abstract
Bacteria can be adapted to adverse and detrimental conditions that induce general and specific responses to DNA damage as well as acid, heat, cold, starvation, oxidative, envelope, and osmotic stresses. The stress-triggered regulatory systems are involved in bacterial survival processes, such as adaptation, [...] Read more.
Bacteria can be adapted to adverse and detrimental conditions that induce general and specific responses to DNA damage as well as acid, heat, cold, starvation, oxidative, envelope, and osmotic stresses. The stress-triggered regulatory systems are involved in bacterial survival processes, such as adaptation, physiological changes, virulence potential, and antibiotic resistance. Antibiotic susceptibility to several antibiotics is reduced due to the activation of stress responses in cellular physiology by the stimulation of resistance mechanisms, the promotion of a resistant lifestyle (biofilm or persistence), and/or the induction of resistance mutations. Hence, the activation of bacterial stress responses poses a serious threat to the efficacy and clinical success of antibiotic therapy. Bacterial stress responses can be potential targets for therapeutic alternatives to antibiotics. An understanding of the regulation of stress response in association with antibiotic resistance provides useful information for the discovery of novel antimicrobial adjuvants and the development of effective therapeutic strategies to control antibiotic resistance in bacteria. Therefore, this review discusses bacterial stress responses linked to antibiotic resistance in Gram-negative bacteria and also provides information on novel therapies targeting bacterial stress responses that have been identified as potential candidates for the effective control of Gram-negative antibiotic-resistant bacteria. Full article
(This article belongs to the Special Issue Control and Detection of Multiple Antibiotic Resistant Pathogens 2.0)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop