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Microorganisms
Special Issues
Oral Microbes and Human Health
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Oral Microbes and Human Health

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 3672

Special Issue Editors

Prof. Dr. Andrea Butera

E-Mail Website1 Website2
Guest Editor
Unit of Dental Hygiene, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy
Interests: dental materials; dental caries; oral diseases; teeth whitening; periodontology; laser dentistry; ozone dentistry; dental education; clinical orthodontics; dental hygiene; oral health
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Andrea Scribante

E-Mail Website
Guest Editor
Unit of Orthodontics and Paediatric Dentistry, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, 27100 Pavia, Italy
Interests: orthodontics; dental hygiene, adhesive dentistry; dental materials; CAD/CAM; intraoral scanner; computerized cast; shear; bond strength; bracket; fiber-reinforced composite; miniscrews; remineralization; probiotics; biomimetic materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are excited to present this Special Issue of Microorganisms, entitled "Oral Microbes and Human Health". Microorganisms (ISSN: 2076-2607, IF 4.5) is an international, peer-reviewed open access journal related to prokaryotic and eukaryotic microorganisms, viruses, and prions.

Oral microbiota are a diverse group of microorganisms that inhabit the human mouth and play an important role in maintaining oral health. However, recent research has suggested that oral microbes may also significantly impact overall human health. This Special Issue aims to provide a comprehensive overview of the current state of knowledge on the relationship between oral microbes and human health.

We welcome high-quality original research and review articles focused on (but not limited to) the following subtopics:

  • Oral microbiota
  • Oral health
  • Systemic diseases
  • Microbial dysbiosis
  • Immune response
  • Therapeutic interventions

The goal of this Special Issue is to advance our understanding of the complex interactions between oral microbes and human health, and to identify potential avenues for future research and therapeutic interventions. We look forward to receiving your contributions.

Prof. Dr. Andrea Butera
Prof. Dr. Andrea Scribante
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral
  • microbiota
  • health

Published Papers (3 papers)

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Research

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15 pages, 1962 KiB  
Article
Human Coronary Artery Endothelial Cell Response to Porphyromonas gingivalis W83 in a Collagen Three-Dimensional Culture Model
by Andrés Cardona-Mendoza, Nelly Stella Roa Molina, Diana Marcela Castillo, Gloria Inés Lafaurie and Diego Fernando Gualtero Escobar
Microorganisms 2024, 12(2), 248; https://doi.org/10.3390/microorganisms12020248 - 24 Jan 2024
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Abstract
P. gingivalis has been reported to be an endothelial cell inflammatory response inducer that can lead to endothelial dysfunction processes related to atherosclerosis; however, these studies have been carried out in vitro in cell culture models on two-dimensional (2D) plastic surfaces that do [...] Read more.
P. gingivalis has been reported to be an endothelial cell inflammatory response inducer that can lead to endothelial dysfunction processes related to atherosclerosis; however, these studies have been carried out in vitro in cell culture models on two-dimensional (2D) plastic surfaces that do not simulate the natural environment where pathology develops. This work aimed to evaluate the pro-inflammatory response of human coronary artery endothelial cells (HCAECs) to P. gingivalis in a 3D cell culture model compared with a 2D cell culture. HCAECs were cultured for 7 days on type I collagen matrices in both cultures and were stimulated at an MOI of 1 or 100 with live P. gingivalis W83 for 24 h. The expression of the genes COX-2, eNOS, and vWF and the levels of the pro-inflammatory cytokines thromboxane A2 (TXA-2) and prostaglandin I2 (PGI2) were evaluated. P. gingivalis W83 in the 2D cell culture increased IL-8 levels at MOI 100 and decreased MCP-1 levels at both MOI 100 and MOI 1. In contrast, the 3D cell culture induced an increased gene expression of COX-2 at both MOIs and reduced MCP-1 levels at MOI 100, whereas the gene expression of eNOS, vWF, and IL-8 and the levels of TXA2 and PGI2 showed no significant changes. These data suggest that in the collagen 3D culture model, P. gingivalis W83 induces a weak endothelial inflammatory response. Full article
(This article belongs to the Special Issue Oral Microbes and Human Health)
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Review

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16 pages, 753 KiB  
Review
A Journey into the Evolution of Human Host-Oral Microbiome Relationship through Ancient Dental Calculus: A Scoping Review
by Alessandra Putrino, Enrico Marinelli, Angela Galeotti, Gianmaria Fabrizio Ferrazzano, Massimiliano Ciribè and Simona Zaami
Microorganisms 2024, 12(5), 902; https://doi.org/10.3390/microorganisms12050902 (registering DOI) - 30 Apr 2024
Abstract
One of the most promising areas of research in palaeomicrobiology is the study of the human microbiome. In particular, ancient dental calculus helps to reconstruct a substantial share of oral microbiome composition by mapping together human evolution with its state of health/oral disease. [...] Read more.
One of the most promising areas of research in palaeomicrobiology is the study of the human microbiome. In particular, ancient dental calculus helps to reconstruct a substantial share of oral microbiome composition by mapping together human evolution with its state of health/oral disease. This review aims to trace microbial characteristics in ancient dental calculus to describe the evolution of the human host-oral microbiome relationship in oral health or disease in children and adults. Following the PRISMA-Extension for Scoping Reviews guidelines, the main scientific databases (PubMed, Scopus, Lilacs, Cochrane Library) have been drawn upon. Eligibility criteria were established, and all the data collected on a purpose-oriented collection form were analysed descriptively. From the initial 340 records, only 19 studies were deemed comprehensive enough for the purpose of this review. The knowledge of the composition of ancient oral microbiomes has broadened over the past few years thanks to increasingly well-performing decontamination protocols and additional analytical avenues. Above all, metagenomic sequencing, also implemented by state-of-the-art bioinformatics tools, allows for the determination of the qualitative-quantitative composition of microbial species associated with health status and caries/periodontal disease. Some microbial species, especially periodontal pathogens, do not appear to have changed in history, while others that support caries disease or oral health could be connected to human evolution through lifestyle and environmental contributing factors. Full article
(This article belongs to the Special Issue Oral Microbes and Human Health)
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Other

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9 pages, 617 KiB  
Opinion
Oral Microbiome and Alzheimer’s Disease
by Jason Wan and Hongkuan Fan
Microorganisms 2023, 11(10), 2550; https://doi.org/10.3390/microorganisms11102550 - 13 Oct 2023
Cited by 1 | Viewed by 2601
Abstract
The accumulation of amyloid-beta plaques in the brain is a central pathological feature of Alzheimer’s disease. It is believed that amyloid responses may be a result of the host immune response to pathogens in both the central nervous system and peripheral systems. Oral [...] Read more.
The accumulation of amyloid-beta plaques in the brain is a central pathological feature of Alzheimer’s disease. It is believed that amyloid responses may be a result of the host immune response to pathogens in both the central nervous system and peripheral systems. Oral microbial dysbiosis is a chronic condition affecting more than 50% of older adults. Recent studies have linked oral microbial dysbiosis to a higher brain Aβ load and the development of Alzheimer’s disease in humans. Moreover, the presence of an oral-derived and predominant microbiome has been identified in the brains of patients with Alzheimer’s disease and other neurodegenerative diseases. Therefore, in this opinion article, we aim to provide a summary of studies on oral microbiomes that may contribute to the pathogenesis of the central nervous system in Alzheimer’s disease. Full article
(This article belongs to the Special Issue Oral Microbes and Human Health)
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