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6.4
4.5
Journals
Microorganisms
Special Issues
Overview of Sepsis and Septic Shock
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Overview of Sepsis and Septic Shock

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 529

Special Issue Editors

Dr. Matteo Guarino

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Guest Editor
Department of Translational Medicine, St. Anna University Hospital of Ferrara, University of Ferrara, 44124 Ferrara, Italy
Interests: sepsis
Prof. Dr. Roberto De Giorgio

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Guest Editor
Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy
Interests: celiac disease; non celiac gluten; wheat sensitivity; intestinal insufficiency; short bowel syndrome; inflammatory bowel disease; acute/chronic pancreatitis; severe functional gastrointestinal disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Sepsis is a time-dependent and life-threatening condition burdened by a high mortality rate. The incidence of sepsis and septic shock has continuously increased since the first consensus definition in 1991, reaching around 49 million cases of sepsis and 11 million sepsis-related deaths worldwide in 2017. These data led the World Health Organization (WHO) to declare sepsis a global health priority.

This Special Issue aims to present the most recent research on sepsis and septic shock. The scope of this Special Issue will be cover but not be limited to the following topics:

  1. Advances in sepsis/septic shock management;
  2. Epidemiology of sepsis;
  3. Sepsis in immunocompromised patients;
  4. New detection strategies;
  5. Sepsis cardiomyopathy,

Furthermore, reviews, original research and communications are welcome.

Dr. Matteo Guarino
Prof. Dr. Roberto De Giorgio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sepsis
  • septic shock

Published Papers (1 paper)

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Research

10 pages, 593 KiB  
Article
Sex- and Gender-Based Analysis on Norepinephrine Use in Septic Shock: Why Is It Still a Male World?
by Benedetta Perna, Valeria Raparelli, Federica Tordo Caprioli, Oana Teodora Blanaru, Cecilia Malacarne, Cecilia Crosetti, Andrea Portoraro, Alex Zanotto, Francesco Maria Strocchi, Alessandro Rapino, Anna Costanzini, Martina Maritati, Roberto Lazzari, Michele Domenico Spampinato, Carlo Contini, Roberto De Giorgio and Matteo Guarino
Microorganisms 2024, 12(4), 821; https://doi.org/10.3390/microorganisms12040821 - 18 Apr 2024
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Abstract
Sex and gender are fundamental health determinants and their role as modifiers of treatment response is increasingly recognized. Norepinephrine is a cornerstone of septic shock management and its use is based on the highest level of evidence compared to dopamine. The related 2021 [...] Read more.
Sex and gender are fundamental health determinants and their role as modifiers of treatment response is increasingly recognized. Norepinephrine is a cornerstone of septic shock management and its use is based on the highest level of evidence compared to dopamine. The related 2021 Surviving Sepsis Campaign (SCC) recommendation is presumably applicable to both females and males; however, a sex- and gender-based analysis is lacking, thus not allowing generalizable conclusions. This paper was aimed at exploring whether sex- and gender-disaggregated data are available in the evidence supporting this recommendation. For all the studies underpinning it, four pairs of authors, including a woman and a man, extracted data concerning sex and gender, according to the Sex and Gender Equity in Research guidelines. Nine manuscripts were included with an overall population of 2126 patients, of which 43.2% were females. No sex analysis was performed and gender was never reported. In conclusion, the present manuscript highlighted that the clinical studies underlying the SCC recommendation of NE administration in septic shock have neglected the likely role of sex and gender as modifiers of treatment response, thus missing the opportunity of sex- and gender-specific guidelines. Full article
(This article belongs to the Special Issue Overview of Sepsis and Septic Shock)
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