Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.4
4.5
Journals
Microorganisms
Special Issues
Bartonella and Bartonellosis: New Advances and Further Challenges
share announcement

Bartonella and Bartonellosis: New Advances and Further Challenges

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 26271

Special Issue Editors

Dr. Marna Ericson

E-Mail Website
Guest Editor
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Interests: vector-borne disease; bartonella infection; biofilms; single- and multi-photon microscopy; second harmonic generation microscopy; skin biology; COVID
Prof. Dr. Lynne T. Bemis

E-Mail Website
Guest Editor
Department of Biomedical Sciences, Duluth Campus, Medical School, University of Minnesota, Duluth, MN 55812, USA
Interests: RNA; bartonella henselae; bacillary angiomatosis; cancer microbiome; tRNA fragments

Special Issue Information

Dear Colleagues,

The genus Bartonella is comprised of fastidious Gram-negative, slow-growing, and facultative intracellular bacteria belonging to the Alpha-2 subgroup of the class Proteobacteria, and the order Rhizobiales. These microorganisms are most often transmitted to humans through animal bites or scratches (cats, dogs, and other animals), by scratch inoculation of infected flea or body louse feces into the skin, and potentially, by bites of other vectors including ants, biting flies, keds, mites, spiders, and ticks. Currently, at least 40 Bartonella species or subspecies have been characterize, of which 17 Bartonella species have been implicated in association with zoonotic infections in humans. These bacteria have become globally important, but medically underappreciated emerging pathogens impacting animal and human health. An infectious disease produced by bacteria of the genus Bartonella is called Bartonellosis and includes Carrion’s disease, cat-scratch disease, chronic lymphadenopathy, trench fever, chronic bacteraemia, culture-negative endocarditis, bacilliary angiomatosis, bacilliary peliosis, vasculitis, and uveitis.

In this Special Issue, I invite reviews or original research articles related to Bartonella and Bartonellosis with a special emphasis on pathogenic mechanisms, prevalence values and findings in diagnostic settings, and signs and symptoms of infection.

Dr. Marna Ericson
Prof. Dr. Lynne T. Bemis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bartonella
  • animal and human bartonellosis
  • zoonosis
  • transmission
  • medicine
  • one health, biofilms
  • RNA
  • imaging

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Other

53 pages, 1492 KiB  
Article
Comparison of the Efficacy of Longer versus Shorter Pulsed High Dose Dapsone Combination Therapy in the Treatment of Chronic Lyme Disease/Post Treatment Lyme Disease Syndrome with Bartonellosis and Associated Coinfections
by Richard I. Horowitz, John Fallon and Phyllis R. Freeman
Microorganisms 2023, 11(9), 2301; https://doi.org/10.3390/microorganisms11092301 - 12 Sep 2023
Cited by 1 | Viewed by 20965
Abstract
Twenty-five patients with relapsing and remitting Borreliosis, Babesiosis, and bartonellosis despite extended anti-infective therapy were prescribed double-dose dapsone combination therapy (DDDCT), followed by one or several courses of High Dose Dapsone Combination Therapy (HDDCT). A retrospective chart review of these 25 patients undergoing [...] Read more.
Twenty-five patients with relapsing and remitting Borreliosis, Babesiosis, and bartonellosis despite extended anti-infective therapy were prescribed double-dose dapsone combination therapy (DDDCT), followed by one or several courses of High Dose Dapsone Combination Therapy (HDDCT). A retrospective chart review of these 25 patients undergoing DDDCT therapy and HDDCT demonstrated that 100% improved their tick-borne symptoms, and patients completing 6–7 day pulses of HDDCT had superior levels of improvement versus 4-day pulses if Bartonella was present. At the completion of treatment, 7/23 (30.5%) who completed 8 weeks of DDDCT followed by a 5–7 day pulse of HDDCT remained in remission for 3–9 months, and 3/23 patients (13%) who recently finished treatment were 1 ½ months in full remission. In conclusion, DDDCT followed by 6–7 day pulses of HDDCT could represent a novel, effective anti-infective strategy in chronic Lyme disease/Post Treatment Lyme Disease Syndrome (PTLDS) and associated co-infections, including Bartonella, especially in individuals who have failed standard antibiotic protocols. Full article
(This article belongs to the Special Issue Bartonella and Bartonellosis: New Advances and Further Challenges)
►▼ Show Figures

Figure 1

Other

Jump to: Research

11 pages, 3366 KiB  
Case Report
Bartonella- and Borrelia-Related Disease Presenting as a Neurological Condition Revealing the Need for Better Diagnostics
by Marna E. Ericson, B. Robert Mozayeni, Laurie Radovsky and Lynne T. Bemis
Microorganisms 2024, 12(1), 209; https://doi.org/10.3390/microorganisms12010209 - 19 Jan 2024
Cited by 2 | Viewed by 3400
Abstract
The diagnostic tests available to identify vector-borne pathogens have major limitations. Clinicians must consider an assortment of often diverse symptoms to decide what pathogen or pathogens to suspect and test for. Even then, there are limitations to the currently available indirect detection methods, [...] Read more.
The diagnostic tests available to identify vector-borne pathogens have major limitations. Clinicians must consider an assortment of often diverse symptoms to decide what pathogen or pathogens to suspect and test for. Even then, there are limitations to the currently available indirect detection methods, such as serology, or direct detection methods such as molecular tests with or without culture enrichment. Bartonella spp., which are considered stealth pathogens, are particularly difficult to detect and diagnose. We present a case report of a patient who experienced a spider bite followed by myalgia, lymphadenopathy, and trouble sleeping. She did not test positive for Bartonella spp. through clinically available testing. Her symptoms progressed and she was told she needed a double hip replacement. Prior to the surgery, her blood was submitted for novel molecular testing, where Bartonella spp. was confirmed, and a spirochete was also detected. Additional testing using novel methods over a period of five years found Bartonella henselae and Borrelia burgdorferi in her blood. This patient’s case is an example of why new diagnostic methods for vector-borne pathogens are urgently needed and why new knowledge of the variable manifestations of Bartonellosis need to be provided to the medical community to inform and heighten their index of suspicion. Full article
(This article belongs to the Special Issue Bartonella and Bartonellosis: New Advances and Further Challenges)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop