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Micromachines
Special Issues
Advanced Biofabrication Technologies
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Advanced Biofabrication Technologies

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "E：Engineering and Technology".

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 34940

Special Issue Editors

Dr. Hee-Gyeong Yi

E-Mail Website
Guest Editor
Department of Rural and Biosystems Engineering, College of Agriculture and Life Sciences, Chonnam National University, Gwangju 61186, Republic of Korea
Interests: 3D bioprinting; bioink; tissue engineering; tumor model; organ-on-a-chip
Dr. Yeong-Jin Choi

E-Mail
Guest Editor
Department of Advanced Biomaterials Research, Korea Institute of Materials Science (KIMS), Changwon 51508, Korea
Interests: 3D bioprinting; bioink; ceramic 3D printing; tissue engineering
Dr. Ge Gao

E-Mail Website
Guest Editor
Institute of Engineering Medicine, Beijing Institute of Technology, Beijing 100081, China
Interests: 3D bioprinting; biomaterials; vascular tissue engineering; in vitro tissue modeling; advanced biofabrication system
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biofabrication integrates the knowledge and skills of multiple subjects (materials science, chemistry, cell biology, molecular biology, mechanical engineering, and medicines). Biofabrication technology has been extensively applied to build biocompatible, bio-matter-laden, or cell-laden constructs for very extensive applications in life sciences and medicine. The advancement in biofabrication technologies has led to outstanding innovations in the area of bioengineering, biology, medical science/device, and healthcare products. However, there are remaining challenges in addressing medically unmet needs that requires breakthroughs in biofabrication.

This Special Issue will present the latest biofabrication technologies. The scope encompasses new biofabrication strategies, advanced system developments, biomaterial formulations, structural design/optimization, innovative therapies, in vitro modeling of pathophysiology, drug exploration, and other relevant topics. Communications, reviews, future perspectives are also welcome. 

Dr. Hee-Gyeong Yi

Dr. Yeong-Jin Choi
Dr. Ge Gao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biofabrication
  • biomaterials
  • bioceramic materials
  • tissue engineering
  • regenerative medicine
  • medical device
  • drug delivery
  • in vitro modeling

Published Papers (7 papers)

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Research

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13 pages, 2601 KiB  
Article
Fabrication of 3D GelMA Scaffolds Using Agarose Microgel Embedded Printing
by Bo Yang, Tianqi Liu, Ge Gao, Xianglin Zhang and Bin Wu
Micromachines 2022, 13(3), 469; https://doi.org/10.3390/mi13030469 - 18 Mar 2022
Cited by 15 | Viewed by 2973
Abstract
Photocrosslinked Gelatin–Methacryloyl (GelMA) has been widely used in the field of 3D bioprinting due to its excellent biological properties, but its properties are not yet optimized. With the advent of embedded printing, the balance between hydrogel printability and cell viability is expected to [...] Read more.
Photocrosslinked Gelatin–Methacryloyl (GelMA) has been widely used in the field of 3D bioprinting due to its excellent biological properties, but its properties are not yet optimized. With the advent of embedded printing, the balance between hydrogel printability and cell viability is expected to be achieved. Agarose microgel is a good support material because of its simple preparation, good biocompatibility, high melting point, and good rheology. In this study, aiming at realizing a GelMA/Agarose suspension printing system, the printing effect of the suspension process was explored, and a suitable process printing window was defined. The resulting scaffolds showed better water absorption and elasticity, but larger deformation during printing. This study explored some potential roles of suspension baths in embedded printing, paving the way for the preparation of good suspension structures that can be convenient for customized tissue engineering applications. Full article
(This article belongs to the Special Issue Advanced Biofabrication Technologies)
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13 pages, 1720 KiB  
Article
3D Bioprinting of an In Vitro Model of a Biomimetic Urinary Bladder with a Contract-Release System
by Suhun Chae, Jaewook Kim, Hee-Gyeong Yi and Dong-Woo Cho
Micromachines 2022, 13(2), 277; https://doi.org/10.3390/mi13020277 - 09 Feb 2022
Cited by 10 | Viewed by 3362
Abstract
The development of curative therapy for bladder dysfunction is usually hampered owing to the lack of reliable ex vivo human models that can mimic the complexity of the human bladder. To overcome this issue, 3D in vitro model systems offering unique opportunities to [...] Read more.
The development of curative therapy for bladder dysfunction is usually hampered owing to the lack of reliable ex vivo human models that can mimic the complexity of the human bladder. To overcome this issue, 3D in vitro model systems offering unique opportunities to engineer realistic human tissues/organs have been developed. However, existing in vitro models still cannot entirely reflect the key structural and physiological characteristics of the native human bladder. In this study, we propose an in vitro model of the urinary bladder that can create 3D biomimetic tissue structures and dynamic microenvironments to replicate the smooth muscle functions of an actual human urinary bladder. In other words, the proposed biomimetic model system, developed using a 3D bioprinting approach, can recreate the physiological motion of the urinary bladder by incorporating decellularized extracellular matrix from the bladder tissue and introducing cyclic mechanical stimuli. The results showed that the developed bladder tissue models exhibited high cell viability and proliferation rate and promoted myogenic differentiation potential given dynamic mechanical cues. We envision the developed in vitro bladder mimicry model can serve as a research platform for fundamental studies on human disease modeling and pharmaceutical testing. Full article
(This article belongs to the Special Issue Advanced Biofabrication Technologies)
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10 pages, 2759 KiB  
Article
Development of Silk Fibroin Scaffolds by Using Indirect 3D-Bioprinting Technology
by Yeong-Jin Choi, Dong-Woo Cho and Hyungseok Lee
Micromachines 2022, 13(1), 43; https://doi.org/10.3390/mi13010043 - 28 Dec 2021
Cited by 15 | Viewed by 3250
Abstract
Due to the excellent biocompatibility of natural polymers, a variety of natural polymers have been widely used as biomaterials for manufacturing tissue engineered scaffolds. Despite the excellent biological activity of natural polymers, there have been obstacles in using them on their own to [...] Read more.
Due to the excellent biocompatibility of natural polymers, a variety of natural polymers have been widely used as biomaterials for manufacturing tissue engineered scaffolds. Despite the excellent biological activity of natural polymers, there have been obstacles in using them on their own to prepare 3D scaffolds with sufficient mechanical strength. Although multiple 3D-bioprinting technologies have recently emerged as effective manufacturing tools for scaffold preparation, scaffold preparation using only natural polymers with tunable mechanical properties is still difficult. Herein, we introduce novel scaffold fabrication methods using the natural polymer silk fibroin via indirect 3D-bioprinting technology. The developed silk fibroin scaffolds showed biocompatibility and tunable mechanical strength by changing the concentration of the silk fibroin. Furthermore, controlling the flexibility of the silk fibroin scaffolds was made possible by changing the solvent for the silk fibroin solution used to fabricate the scaffold. Consequently, silk fibroin scaffolds fabricated via our method can be considered for various applications in the bioengineering of either soft or musculoskeletal tissues. Full article
(This article belongs to the Special Issue Advanced Biofabrication Technologies)
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Review

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16 pages, 3723 KiB  
Review
A Review on Manufacturing and Post-Processing Technology of Vascular Stents
by Wei Jiang, Wenxiang Zhao, Tianfeng Zhou, Liang Wang and Tianyang Qiu
Micromachines 2022, 13(1), 140; https://doi.org/10.3390/mi13010140 - 16 Jan 2022
Cited by 18 | Viewed by 6127
Abstract
Percutaneous coronary intervention (PCI) with stent implantation is one of the most effective treatments for cardiovascular diseases (CVDs). However, there are still many complications after stent implantation. As a medical device with a complex structure and small size, the manufacture and post-processing technology [...] Read more.
Percutaneous coronary intervention (PCI) with stent implantation is one of the most effective treatments for cardiovascular diseases (CVDs). However, there are still many complications after stent implantation. As a medical device with a complex structure and small size, the manufacture and post-processing technology greatly impact the mechanical and medical performances of stents. In this paper, the development history, material, manufacturing method, and post-processing technology of vascular stents are introduced. In particular, this paper focuses on the existing manufacturing technology and post-processing technology of vascular stents and the impact of these technologies on stent performance is described and discussed. Moreover, the future development of vascular stent manufacturing technology will be prospected and proposed. Full article
(This article belongs to the Special Issue Advanced Biofabrication Technologies)
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31 pages, 3317 KiB  
Review
Micro/Nanopatterned Superhydrophobic Surfaces Fabrication for Biomolecules and Biomaterials Manipulation and Analysis
by Marco Allione, Tania Limongi, Monica Marini, Bruno Torre, Peng Zhang, Manola Moretti, Gerardo Perozziello, Patrizio Candeloro, Lucia Napione, Candido Fabrizio Pirri and Enzo Di Fabrizio
Micromachines 2021, 12(12), 1501; https://doi.org/10.3390/mi12121501 - 30 Nov 2021
Cited by 7 | Viewed by 3163
Abstract
Superhydrophobic surfaces display an extraordinary repulsion to water and water-based solutions. This effect emerges from the interplay of intrinsic hydrophobicity of the surface and its morphology. These surfaces have been established for a long time and have been studied for decades. The increasing [...] Read more.
Superhydrophobic surfaces display an extraordinary repulsion to water and water-based solutions. This effect emerges from the interplay of intrinsic hydrophobicity of the surface and its morphology. These surfaces have been established for a long time and have been studied for decades. The increasing interest in recent years has been focused towards applications in many different fields and, in particular, biomedical applications. In this paper, we review the progress achieved in the last years in the fabrication of regularly patterned superhydrophobic surfaces in many different materials and their exploitation for the manipulation and characterization of biomaterial, with particular emphasis on the issues affecting the yields of the fabrication processes and the quality of the manufactured devices. Full article
(This article belongs to the Special Issue Advanced Biofabrication Technologies)
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17 pages, 1955 KiB  
Review
Recapitulating the Cancer Microenvironment Using Bioprinting Technology for Precision Medicine
by Jisoo Kim, Jinah Jang and Dong-Woo Cho
Micromachines 2021, 12(9), 1122; https://doi.org/10.3390/mi12091122 - 17 Sep 2021
Cited by 7 | Viewed by 2902
Abstract
The complex and heterogenous nature of cancer contributes to the development of cancer cell drug resistance. The construction of the cancer microenvironment, including the cell–cell interactions and extracellular matrix (ECM), plays a significant role in the development of drug resistance. Traditional animal models [...] Read more.
The complex and heterogenous nature of cancer contributes to the development of cancer cell drug resistance. The construction of the cancer microenvironment, including the cell–cell interactions and extracellular matrix (ECM), plays a significant role in the development of drug resistance. Traditional animal models used in drug discovery studies have been associated with feasibility issues that limit the recapitulation of human functions; thus, in vitro models have been developed to reconstruct the human cancer system. However, conventional two-dimensional and three-dimensional (3D) in vitro cancer models are limited in their ability to emulate complex cancer microenvironments. Advances in technologies, including bioprinting and cancer microenvironment reconstruction, have demonstrated the potential to overcome some of the limitations of conventional models. This study reviews some representative bioprinted in vitro models used in cancer research, particularly fabrication strategies for modeling and consideration of essential factors needed for the reconstruction of the cancer microenvironment. In addition, we highlight recent studies that applied such models, including application in precision medicine using advanced bioprinting technologies to fabricate biomimetic cancer models. Furthermore, we discuss current challenges in 3D bioprinting and suggest possible strategies to construct in vitro models that better mimic the pathophysiology of the cancer microenvironment for application in clinical settings. Full article
(This article belongs to the Special Issue Advanced Biofabrication Technologies)
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26 pages, 8782 KiB  
Review
Structural Design of Vascular Stents: A Review
by Chen Pan, Yafeng Han and Jiping Lu
Micromachines 2021, 12(7), 770; https://doi.org/10.3390/mi12070770 - 29 Jun 2021
Cited by 35 | Viewed by 11726
Abstract
Percutaneous Coronary Intervention (PCI) is currently the most conventional and effective method for clinically treating cardiovascular diseases such as atherosclerosis. Stent implantation, as one of the ways of PCI in the treatment of coronary artery diseases, has become a hot spot in scientific [...] Read more.
Percutaneous Coronary Intervention (PCI) is currently the most conventional and effective method for clinically treating cardiovascular diseases such as atherosclerosis. Stent implantation, as one of the ways of PCI in the treatment of coronary artery diseases, has become a hot spot in scientific research with more and more patients suffering from cardiovascular diseases. However, vascular stent implanted into vessels of patients often causes complications such as In-Stent Restenosis (ISR). The vascular stent is one of the sophisticated medical devices, a reasonable structure of stent can effectively reduce the complications. In this paper, we introduce the evolution, performance evaluation standards, delivery and deployment, and manufacturing methods of vascular stents. Based on a large number of literature pieces, this paper focuses on designing structures of vascular stents in terms of “bridge (or link)” type, representative volume unit (RVE)/representative unit cell (RUC), and patient-specific stent. Finally, this paper gives an outlook on the future development of designing vascular stents. Full article
(This article belongs to the Special Issue Advanced Biofabrication Technologies)
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