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Micromachines
Special Issues
Advanced Biomanufacturing for Biomedical Engineering Applications, 2nd Edition
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Advanced Biomanufacturing for Biomedical Engineering Applications, 2nd Edition

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "E：Engineering and Technology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 742

Special Issue Editor

Dr. Liqun Ning

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Cleveland State University, Cleveland, OH 44115, USA
Interests: advanced manufacturing; biomaterials; biomechanics; regenerative medicine; disease modelling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Advanced biomanufacturing, along with biomaterials and cell/stem cell technology, has shown great promise for engineering highly tunable tissue analogues to address significant challenges in biomedical engineering. This Special Issue aims to collect high-quality original and review articles on the development/creation of cutting-edge engineering technologies, artificial constructs, and devices for broad applications in biomedical engineering and to explore the most important questions in the field. The topics include, but are not limited to, advanced biomanufacturing, 3D printing and bioprinting, biomaterials and bioinks, biomanufactured constructs/devices for regenerative medicine, disease modeling, and drug screening, as well as advanced imaging methods/technologies to non-invasively track biomanufactured structures in living animal models and/or human patients.

Dr. Liqun Ning
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • advanced biomanufacturing
  • biomaterials
  • cell/stem cell
  • regenerative medicine
  • disease modeling
  • drug screening
  • advanced imaging

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Published Papers (1 paper)

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Research

19 pages, 2441 KiB  
Article
A Simulation of the Mechanical Testing of the Cell Membrane and Cytoskeleton
by Yue Du, Dai Cheng, Zhanli Yang, Yaowei Liu, Qili Zhao, Mingzhu Sun, Haifeng Li and Xin Zhao
Micromachines 2024, 15(4), 431; https://doi.org/10.3390/mi15040431 - 23 Mar 2024
Viewed by 599
Abstract
Cell models play a crucial role in analyzing the mechanical response of cells and quantifying cellular damage incurred during micromanipulation. While traditional models can capture the overall mechanical behavior of cells, they often lack the ability to discern among distinct cellular components. Consequently, [...] Read more.
Cell models play a crucial role in analyzing the mechanical response of cells and quantifying cellular damage incurred during micromanipulation. While traditional models can capture the overall mechanical behavior of cells, they often lack the ability to discern among distinct cellular components. Consequently, by employing dissipative particle dynamics, this study constructed a triangular network-like representation of the cell membrane along with cross-linked cytoskeletal chains. The mechanical properties of both the membrane and cytoskeleton were then analyzed through a series of simulated mechanical tests, validated against real-world experiments. The investigation utilized particle-tracking rheology to monitor changes in the mean square displacements of membrane particles over time, facilitating the analysis of the membrane’s storage and loss moduli. Additionally, the cytoskeletal network’s storage and loss moduli were examined via a double-plate oscillatory shear experiment. The simulation results revealed that both the membrane and cytoskeleton exhibit viscoelastic behavior, as evidenced by the power-law dependency of their storage and loss moduli on frequency. Furthermore, indentation and microinjection simulations were conducted to examine the overall mechanical properties of cells. In the indentation experiments, an increase in the shear modulus of the membrane’s WLCs correlated with a higher Young’s modulus for the entire cell. Regarding the microinjection experiment, augmenting the microinjection speed resulted in reduced deformation of the cell at the point of membrane rupture and a lower percentage of high strain. Full article
(This article belongs to the Special Issue Advanced Biomanufacturing for Biomedical Engineering Applications, 2nd Edition)
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